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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RAI1

Summary for RAI1

Gene information	Gene symbol	RAI1
	Ensembl ID	ENSG00000108557
	Entrez ID	10743
	Gene name	retinoic acid induced 1
	Synonyms	DKFZP434A139\|KIAA1820\|MGC12824\|SMCR\|SMS
	Gene type	protein_coding
	UniProtAcc	Q7Z5J4

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Dataset with differentially expressed gene: RAI1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.338618	1.88e-35

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Expression of RAI1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RAI1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RAI1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RAI1	hsa-miR-5011-5p	99.9947	NM_030665
RAI1	hsa-miR-190a-3p	99.8985	NM_030665
RAI1	hsa-miR-3924	94.8857	NM_030665
RAI1	hsa-miR-582-5p	93.3962	NM_030665
RAI1	hsa-miR-4651	92.7077	NM_030665
RAI1	hsa-miR-608	92.7077	NM_030665
RAI1	hsa-miR-4650-5p	92.7049	NM_030665
RAI1	hsa-miR-651-3p	92.1882	NM_030665
RAI1	hsa-miR-411-3p	91.7068	NM_030665
RAI1	hsa-miR-379-3p	91.7068	NM_030665
RAI1	hsa-miR-656-3p	91.6171	NM_030665
RAI1	hsa-miR-4262	91.3411	NM_030665
RAI1	hsa-miR-8485	91.0814	NM_030665
RAI1	hsa-miR-181b-5p	90.3474	NM_030665
RAI1	hsa-miR-181d-5p	90.3474	NM_030665
RAI1	hsa-miR-181a-5p	90.3474	NM_030665
RAI1	hsa-miR-181c-5p	90.3474	NM_030665
RAI1	hsa-miR-194-5p	89.5453	NM_030665
RAI1	hsa-miR-369-3p	88.4802	NM_030665
RAI1	hsa-miR-106a-3p	86.042	NM_030665
RAI1	hsa-miR-3941	85.9928	NM_030665
RAI1	hsa-miR-5007-3p	85.2058	NM_030665
RAI1	hsa-miR-4302	84.6253	NM_030665
RAI1	hsa-let-7a-2-3p	82.9901	NM_030665
RAI1	hsa-miR-6768-5p	82.9059	NM_030665
RAI1	hsa-miR-655-3p	81.4212	NM_030665
RAI1	hsa-miR-374c-5p	81.4212	NM_030665
RAI1	hsa-miR-603	80.815	NM_030665
RAI1	hsa-miR-362-3p	80.815	NM_030665
RAI1	hsa-miR-329-3p	80.815	NM_030665
RAI1	hsa-let-7g-3p	80.0235	NM_030665

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Motifs and transcription factors (TFs) regulating RAI1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RAI1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
RAI1	metacluster_7.13	ZFX (directAnnotation).
RAI1	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
RAI1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
RAI1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
RAI1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
RAI1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
RAI1	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."