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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: RAF1

Summary for RAF1

Gene information	Gene symbol	RAF1
	Ensembl ID	ENSG00000132155
	Entrez ID	5894
	Gene name	Raf-1 proto-oncogene, serine/threonine kinase
	Synonyms	c-Raf\|CRAF\|Raf-1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: RAF1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.25681	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.258652	9.34e-04
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.321075	0.00e+00

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Expression of RAF1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RAF1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
RAF1	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating RAF1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RAF1	hsa-miR-8068	99.5655	NM_002880
RAF1	hsa-miR-7-5p	96.8427	NM_002880
RAF1	hsa-miR-605-3p	96.2167	NM_002880
RAF1	hsa-miR-4803	92.9105	NM_002880
RAF1	hsa-miR-19a-3p	92.8636	NM_002880
RAF1	hsa-miR-19b-3p	92.8636	NM_002880
RAF1	hsa-miR-624-5p	92.5538	NM_002880
RAF1	hsa-miR-646	91.0327	NM_002880
RAF1	hsa-miR-548x-3p	90.7887	NM_002880
RAF1	hsa-miR-548aj-3p	90.7887	NM_002880
RAF1	hsa-miR-548as-3p	90.7872	NM_002880
RAF1	hsa-miR-548ah-3p	90.6076	NM_002880
RAF1	hsa-miR-548bb-3p	90.6076	NM_002880
RAF1	hsa-miR-548am-3p	90.6076	NM_002880
RAF1	hsa-miR-548d-3p	90.6076	NM_002880
RAF1	hsa-miR-548aq-3p	90.6076	NM_002880
RAF1	hsa-miR-548h-3p	90.6076	NM_002880
RAF1	hsa-miR-548j-3p	90.6076	NM_002880
RAF1	hsa-miR-548ac	90.6076	NM_002880
RAF1	hsa-miR-548z	90.6076	NM_002880
RAF1	hsa-miR-548ae-3p	90.6076	NM_002880
RAF1	hsa-miR-6077	84.944	NM_002880
RAF1	hsa-miR-4742-3p	83.7625	NM_002880
RAF1	hsa-miR-764	83.2083	NM_002880

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Motifs and transcription factors (TFs) regulating RAF1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RAF1	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
RAF1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
RAF1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
RAF1	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
RAF1	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
RAF1	transfac_pro__M04866	HDAC2 (directAnnotation).
RAF1	jaspar__MA1122.1	TFDP1 (directAnnotation).
RAF1	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
RAF1	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
RAF1	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
RAF1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
RAF1	kznf__ZNF846_Imbeault2017_RP_ChIP-seq	ZNF846 (directAnnotation).
RAF1	transfac_pro__M12686	ZBTB10 (directAnnotation).
RAF1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
RAF1	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
RAF1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
RAF1	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
RAF1	transfac_pro__M04617	ZBTB7A (directAnnotation).
RAF1	transfac_pro__M01973	PLAG1 (directAnnotation).
RAF1	metacluster_151.2	ZNF23 (directAnnotation).
RAF1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
RAF1	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
RAF1	metacluster_66.1	MTF1; ZNF320; ZNF320; ZNF320; ZNF782 (directAnnotation).
RAF1	cisbp__M01864	EGR1 (inferredBy_Orthology).
RAF1	tfdimers__MD00391	KLF4 (directAnnotation).
RAF1	kznf__ZNF267_Imbeault2017_RP_RCADE	ZNF267 (directAnnotation).
RAF1	transfac_pro__M05479	ZNF580 (directAnnotation).
RAF1	tfdimers__MD00151	CHURC1 (directAnnotation).
RAF1	transfac_pro__M04817	ZBTB33 (directAnnotation).
RAF1	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
RAF1	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
RAF1	metacluster_3.10	KLF2; KLF4 (directAnnotation).
RAF1	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
RAF1	transfac_pro__M01253	CNOT3 (directAnnotation).
RAF1	cisbp__M00968	MTF2 (directAnnotation).
RAF1	tfdimers__MD00038	TFAP2C (directAnnotation).
RAF1	taipale_tf_pairs__E2F3_TBX21_NGGTGTGNNGGCGCSN_CAP_repr	E2F3; TBX21 (directAnnotation).
RAF1	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
RAF1	metacluster_115.1	NEUROD1; PHF1; ZBTB20; ZNF17; ZNF296; ZNF350; ZNF486; ZNF574; ZNF589; ZNF891 (directAnnotation). IRF4; IRF6; PRDM5 (inferredBy_Orthology).
RAF1	metacluster_3.14	WT1; WT1 (directAnnotation).
RAF1	transfac_pro__M12697	ZNF142 (directAnnotation).
RAF1	transfac_pro__M07387	ZBTB7A (directAnnotation).
RAF1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
RAF1	transfac_pro__M04893	TAF1 (directAnnotation).
RAF1	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
RAF1	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
RAF1	kznf__EGR2_Barrera2016.3_PBM	EGR2 (directAnnotation).
RAF1	transfac_pro__M00986	CHURC1 (directAnnotation).
RAF1	metacluster_182.2	GCM1; GCM1; GCM1; GCM1; GCM2; GCM2 (directAnnotation). GCM1; GCM1; GCM1; GCM1; GCM2; GCM2 (inferredBy_Orthology).
RAF1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
RAF1	"Cholecystokinin"	DB08862	small molecule
RAF1	"Dabrafenib"	DB08912	small molecule
RAF1	"Fostamatinib"	DB12010	small molecule
RAF1	"iCo-007"	DB05268	small molecule
RAF1	"LErafAON"	DB04973	biotech
RAF1	"Regorafenib"	DB08896	small molecule
RAF1	"Sorafenib"	DB00398	small molecule
RAF1	"XL281"	DB05190	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."