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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RAD23B

Summary for RAD23B

Gene information	Gene symbol	RAD23B
	Ensembl ID	ENSG00000119318
	Entrez ID	5887
	Gene name	RAD23 homolog B, nucleotide excision repair protein
	Synonyms	HHR23B\|HR23B\|P58
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: RAD23B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.287758	2.21e-18
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.614227	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.306863	1.70e-09
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.386029	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.268441	2.13e-12
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.27652	8.37e-08
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.30592	1.28e-10
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.373262	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.367357	2.12e-24

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Expression of RAD23B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RAD23B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RAD23B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RAD23B	hsa-miR-335-3p	99.5698	NM_001244713
RAD23B	hsa-miR-10523-5p	97.8517	NM_001244724
RAD23B	hsa-miR-199a-5p	97.2476	NM_001244713
RAD23B	hsa-miR-199b-5p	97.2476	NM_001244713
RAD23B	hsa-miR-3658	96.6186	NM_001244713
RAD23B	hsa-miR-4775	95.6427	NM_001244724
RAD23B	hsa-miR-1825	94.479	NM_001244713
RAD23B	hsa-miR-3613-3p	93.3864	NM_001244724
RAD23B	hsa-miR-4659b-5p	92.3553	NM_001244713
RAD23B	hsa-miR-6752-3p	92.1646	NM_001244713
RAD23B	hsa-miR-424-5p	92.0314	NM_001244713
RAD23B	hsa-miR-15a-5p	92.0314	NM_001244713
RAD23B	hsa-miR-6838-5p	92.0314	NM_001244713
RAD23B	hsa-miR-195-5p	92.0314	NM_001244713
RAD23B	hsa-miR-16-5p	92.0314	NM_001244713
RAD23B	hsa-miR-497-5p	92.0314	NM_001244713
RAD23B	hsa-miR-15b-5p	92.0314	NM_001244713
RAD23B	hsa-miR-548ax	91.4258	NM_001244724
RAD23B	hsa-miR-548ao-5p	91.4258	NM_001244724
RAD23B	hsa-miR-30d-5p	91.3327	NM_001244713
RAD23B	hsa-miR-30c-5p	91.3327	NM_001244713
RAD23B	hsa-miR-30e-5p	91.3327	NM_001244713
RAD23B	hsa-miR-30a-5p	91.3327	NM_001244713
RAD23B	hsa-miR-30b-5p	91.3327	NM_001244713
RAD23B	hsa-miR-4659a-5p	91.0432	NM_001244713
RAD23B	hsa-miR-744-3p	91.0431	NM_001244713
RAD23B	hsa-miR-4782-5p	90.3487	NM_001244724
RAD23B	hsa-miR-5706	90.3487	NM_001244724
RAD23B	hsa-miR-4752	90.0585	NM_001244724
RAD23B	hsa-miR-6071	89.3699	NM_001244724
RAD23B	hsa-miR-508-3p	87.7634	NM_001244713
RAD23B	hsa-miR-4712-5p	86.4367	NM_001244724
RAD23B	hsa-miR-770-5p	86.4367	NM_001244724
RAD23B	hsa-miR-7856-5p	85.8533	NM_001244713
RAD23B	hsa-miR-494-3p	85.7979	NM_001244724
RAD23B	hsa-miR-4729	85.2455	NM_001244713
RAD23B	hsa-miR-5586-5p	85.2254	NM_001244713
RAD23B	hsa-miR-590-3p	85.055	NM_001244724
RAD23B	hsa-miR-2115-3p	83.8361	NM_001244724
RAD23B	hsa-miR-150-5p	83.5234	NM_001244713
RAD23B	hsa-miR-944	83.4815	NM_001244724
RAD23B	hsa-miR-7978	83.3924	NM_001244713
RAD23B	hsa-miR-372-5p	83.3289	NM_001244724
RAD23B	hsa-miR-1287-5p	83.2598	NM_001244724
RAD23B	hsa-miR-874-5p	83.0489	NM_001244724
RAD23B	hsa-miR-410-3p	82.8838	NM_001244724
RAD23B	hsa-miR-4686	82.2385	NM_001244713
RAD23B	hsa-miR-1233-3p	81.9765	NM_001244713
RAD23B	hsa-miR-1225-3p	81.9765	NM_001244713
RAD23B	hsa-miR-510-3p	81.9669	NM_001244724

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Motifs and transcription factors (TFs) regulating RAD23B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RAD23B	metacluster_7.13	ZFX (directAnnotation).
RAD23B	metacluster_151.2	ZNF23 (directAnnotation).
RAD23B	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
RAD23B	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
RAD23B	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
RAD23B	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
RAD23B	transfac_pro__M05628	ZNF735 (directAnnotation).
RAD23B	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
RAD23B	jaspar__MA0079.5	SP1 (directAnnotation).
RAD23B	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
RAD23B	taipale_tf_pairs__ELK1_TEF_NSCGGAWNTTACGTAAN_CAP	ELK1; TEF (directAnnotation).
RAD23B	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
RAD23B	taipale_tf_pairs__ETV5_CEBPD_NSCGGANNTTRCGYAAN_CAP	CEBPD; ETV5 (directAnnotation).
RAD23B	transfac_pro__M00652	NRF1 (directAnnotation).
RAD23B	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
RAD23B	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
RAD23B	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
RAD23B	cisbp__M00249	WT1 (directAnnotation).
RAD23B	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
RAD23B	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
RAD23B	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
RAD23B	metacluster_182.10	ZFX (directAnnotation).
RAD23B	cisbp__M00788	ZFY (inferredBy_Orthology).
RAD23B	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
RAD23B	hdpi__TP73	TP73 (directAnnotation).
RAD23B	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
RAD23B	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
RAD23B	transfac_pro__M01199	TRIM28 (directAnnotation).
RAD23B	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).
RAD23B	metacluster_81.7	CREB1 (directAnnotation).
RAD23B	cisbp__M00808	MYPOP (inferredBy_Orthology).
RAD23B	hdpi__GTF3C2	GTF3C2 (directAnnotation).
RAD23B	transfac_pro__M03806	ZBTB7C (directAnnotation).
RAD23B	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
RAD23B	hdpi__NRL	NRL (directAnnotation).
RAD23B	tfdimers__MD00483	ZBTB14 (directAnnotation).
RAD23B	metacluster_126.7	CTCF; ZFY; ZSCAN30 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."