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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RABEP1

Summary for RABEP1

Gene information	Gene symbol	RABEP1
	Ensembl ID	ENSG00000029725
	Entrez ID	9135
	Gene name	rabaptin, RAB GTPase binding effector protein 1
	Synonyms	neurocrescin\|RAB5EP\|rabaptin-5\|RABPT5
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: RABEP1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.39076	5.15e-14
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	0.292873	1.37e-12
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.469223	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.296918	4.83e-14
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.335994	4.28e-13
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.379524	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.301039	0.00e+00

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Expression of RABEP1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RABEP1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RABEP1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RABEP1	hsa-miR-522-3p	98.9147	NM_001083585
RABEP1	hsa-miR-224-3p	98.9147	NM_001083585
RABEP1	hsa-miR-4424	98.9106	NM_001083585
RABEP1	hsa-miR-3151-3p	97.3759	NM_001083585
RABEP1	hsa-miR-587	96.2166	NM_001083585
RABEP1	hsa-miR-374a-5p	95.4447	NM_001083585
RABEP1	hsa-miR-374b-5p	95.117	NM_001083585
RABEP1	hsa-miR-218-5p	94.7165	NM_001083585
RABEP1	hsa-miR-4735-5p	94.5463	NM_001083585
RABEP1	hsa-miR-3163	93.7447	NM_001083585
RABEP1	hsa-miR-4469	92.3117	NM_001083585
RABEP1	hsa-miR-548as-3p	91.1213	NM_001083585
RABEP1	hsa-miR-4686	90.1258	NM_001083585
RABEP1	hsa-miR-6873-3p	88.6302	NM_001083585
RABEP1	hsa-miR-222-5p	88.5886	NM_001083585
RABEP1	hsa-miR-6867-3p	88.4069	NM_001083585
RABEP1	hsa-miR-5692a	87.4649	NM_001083585
RABEP1	hsa-miR-548d-3p	86.8907	NM_001083585
RABEP1	hsa-miR-548z	86.8907	NM_001083585
RABEP1	hsa-miR-548h-3p	86.8907	NM_001083585
RABEP1	hsa-miR-548ac	86.8907	NM_001083585
RABEP1	hsa-miR-548bb-3p	86.8907	NM_001083585
RABEP1	hsa-miR-1236-3p	85.7927	NM_001083585
RABEP1	hsa-miR-4744	85.576	NM_001083585
RABEP1	hsa-miR-510-3p	85.0281	NM_001083585
RABEP1	hsa-miR-514b-3p	84.4743	NM_001083585
RABEP1	hsa-miR-514a-3p	84.4743	NM_001083585
RABEP1	hsa-miR-130b-5p	84.2966	NM_001083585
RABEP1	hsa-miR-7-5p	84.1506	NM_001083585
RABEP1	hsa-miR-6072	83.9784	NM_001083585
RABEP1	hsa-miR-6820-3p	83.7583	NM_001083585
RABEP1	hsa-miR-3164	83.7583	NM_001083585
RABEP1	hsa-miR-6760-5p	82.5889	NM_001083585
RABEP1	hsa-miR-889-3p	82.2671	NM_001083585
RABEP1	hsa-miR-6878-5p	82.0979	NM_001083585
RABEP1	hsa-miR-6502-5p	81.4125	NM_001083585
RABEP1	hsa-miR-1301-5p	81.4125	NM_001083585
RABEP1	hsa-miR-4255	81.1078	NM_001083585

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Motifs and transcription factors (TFs) regulating RABEP1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RABEP1	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
RABEP1	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
RABEP1	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
RABEP1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
RABEP1	jaspar__MA0748.2	YY2 (directAnnotation).
RABEP1	metacluster_182.10	ZFX (directAnnotation).
RABEP1	metacluster_81.7	CREB1 (directAnnotation).
RABEP1	metacluster_34.1	ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).
RABEP1	hocomoco__KAISO_HUMAN.H11MO.2.A	ZBTB33 (directAnnotation).
RABEP1	transfac_pro__M04748	GABPA (directAnnotation).
RABEP1	kznf__ZNF441_Imbeault2017_OM_RCADE	ZNF441 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."