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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: RAB9A

Summary for RAB9A

Gene information	Gene symbol	RAB9A
	Ensembl ID	ENSG00000123595
	Entrez ID	9367
	Gene name	RAB9A, member RAS oncogene family
	Synonyms	RAB9
	Gene type	protein_coding
	UniProtAcc	P51151

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Dataset with differentially expressed gene: RAB9A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.550076	1.40e-45
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.532056	3.56e-25
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.787333	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.363844	1.04e-11
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.502847	0.00e+00

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Expression of RAB9A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RAB9A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RAB9A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RAB9A	hsa-miR-4775	96.5524	NM_001195328
RAB9A	hsa-miR-466	96.0556	NM_001195328
RAB9A	hsa-miR-137-3p	95.6416	NM_001195328
RAB9A	hsa-miR-590-3p	94.8711	NM_001195328
RAB9A	hsa-miR-5010-3p	94.8134	NM_001195328
RAB9A	hsa-miR-4789-3p	93.8995	NM_001195328
RAB9A	hsa-miR-571	92.482	NM_001195328
RAB9A	hsa-miR-6792-3p	87.6924	NM_001195328
RAB9A	hsa-miR-4691-5p	87.6924	NM_001195328
RAB9A	hsa-miR-136-5p	87.6469	NM_001195328
RAB9A	hsa-miR-519e-5p	86.6368	NM_001195328
RAB9A	hsa-miR-515-5p	86.6368	NM_001195328
RAB9A	hsa-miR-6840-3p	85.6886	NM_001195328
RAB9A	hsa-miR-15b-5p	85.4058	NM_001195328
RAB9A	hsa-miR-497-5p	85.4058	NM_001195328
RAB9A	hsa-miR-6838-5p	85.4058	NM_001195328
RAB9A	hsa-miR-16-5p	85.4058	NM_001195328
RAB9A	hsa-miR-15a-5p	85.4058	NM_001195328
RAB9A	hsa-miR-424-5p	85.4058	NM_001195328
RAB9A	hsa-miR-195-5p	85.4058	NM_001195328
RAB9A	hsa-miR-889-3p	84.2119	NM_001195328
RAB9A	hsa-miR-4713-5p	82.0657	NM_001195328
RAB9A	hsa-miR-4643	81.3226	NM_001195328
RAB9A	hsa-miR-4668-3p	81.2115	NM_001195328
RAB9A	hsa-miR-891b	80.2678	NM_001195328

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Motifs and transcription factors (TFs) regulating RAB9A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RAB9A	metacluster_135.11	NR2C2 (directAnnotation).
RAB9A	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
RAB9A	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
RAB9A	metacluster_7.13	ZFX (directAnnotation).
RAB9A	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
RAB9A	cisbp__M00968	MTF2 (directAnnotation).
RAB9A	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
RAB9A	metacluster_160.20	JUND; PRDM15 (directAnnotation).
RAB9A	cisbp__M00341	PAX6 (directAnnotation).
RAB9A	metacluster_198.3	ZFP64 (directAnnotation).
RAB9A	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
RAB9A	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
RAB9A	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
RAB9A	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
RAB9A	cisbp__M00788	ZFY (inferredBy_Orthology).
RAB9A	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
RAB9A	metacluster_175.1	ZNF283 (directAnnotation).
RAB9A	hdpi__ZNF304	ZNF304 (directAnnotation).
RAB9A	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
RAB9A	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
RAB9A	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
RAB9A	transfac_pro__M01199	TRIM28 (directAnnotation).
RAB9A	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
RAB9A	metacluster_151.2	ZNF23 (directAnnotation).
RAB9A	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
RAB9A	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
RAB9A	transfac_pro__M03806	ZBTB7C (directAnnotation).
RAB9A	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
RAB9A	transfac_pro__M04826	EP300 (directAnnotation).
RAB9A	jaspar__MA1708.1	ETV7 (directAnnotation).
RAB9A	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
RAB9A	hdpi__ELF2	ELF2 (directAnnotation).
RAB9A	swissregulon__hs__ELK1	ELK1 (directAnnotation).
RAB9A	metacluster_57.3	ARNT; ATF3; ATF3; ATF3; ATF3; BHLHE40; BHLHE40; BHLHE40; BHLHE41; BHLHE41; BHLHE41; MITF; MITF; MITF; MLX; MLXIPL; SREBF1; SREBF1; SREBF1; SREBF1; SREBF2; SREBF2; SREBF2; TFE3; TFEC; USF1; USF1; USF1; USF1; USF1; USF1; USF1; USF1; USF1; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; ZNF507 (directAnnotation). ARNTL; BHLHE40; BHLHE40; BHLHE41; HELT; HES1; HES2; HES3; HES5; HES6; HES7; HEY1; HEY2; HEYL; MLX; MLX; SREBF1; SREBF2; TFE3; USF1; USF1; USF2; USF2 (inferredBy_Orthology).
RAB9A	taipale_tf_pairs__TEAD4_ETV4_RCCGGAAATRCC_CAP	ETV4; TEAD4 (directAnnotation).
RAB9A	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
RAB9A	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).
RAB9A	metacluster_81.7	CREB1 (directAnnotation).
RAB9A	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
RAB9A	taipale_tf_pairs__ETV5_HOXA13_NNCGGAWGTNRTWAA_CAP	ETV5; HOXA13 (directAnnotation).
RAB9A	cisbp__M00808	MYPOP (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
RAB9A	"Guanosine-5'-Diphosphate"	DB04315	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."