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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RAB6A

Summary for RAB6A

Gene information	Gene symbol	RAB6A
	Ensembl ID	ENSG00000175582
	Entrez ID	5870
	Gene name	RAB6A, member RAS oncogene family
	Synonyms	RAB6
	Gene type	protein_coding
	UniProtAcc	P20340

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Dataset with differentially expressed gene: RAB6A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.556813	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.379468	4.56e-32

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Expression of RAB6A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RAB6A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
RAB6A	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating RAB6A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RAB6A	hsa-miR-548e-5p	99.0154	NM_002869
RAB6A	hsa-miR-6806-3p	98.5014	NM_002869
RAB6A	hsa-miR-3928-5p	98.5014	NM_002869
RAB6A	hsa-miR-6835-3p	96.8156	NM_002869
RAB6A	hsa-miR-3143	95.7153	NM_002869
RAB6A	hsa-miR-195-3p	95.3804	NM_002869
RAB6A	hsa-miR-16-2-3p	95.3804	NM_002869
RAB6A	hsa-miR-6817-5p	92.3048	NM_002869
RAB6A	hsa-miR-4769-3p	92.3048	NM_002869
RAB6A	hsa-miR-3119	91.7671	NM_002869
RAB6A	hsa-miR-7515	91.7635	NM_002869
RAB6A	hsa-miR-12132	90.9919	NM_002869
RAB6A	hsa-miR-892a	90.9653	NM_002869
RAB6A	hsa-miR-664b-5p	89.2754	NM_002869
RAB6A	hsa-miR-3910	87.9062	NM_002869
RAB6A	hsa-miR-636	87.6907	NM_002869
RAB6A	hsa-miR-4735-5p	87.6177	NM_002869
RAB6A	hsa-miR-5584-5p	86.6823	NM_002869
RAB6A	hsa-miR-3611	86.365	NM_002869
RAB6A	hsa-miR-8068	86.1764	NM_002869
RAB6A	hsa-miR-4659b-5p	85.7881	NM_002869
RAB6A	hsa-miR-127-5p	85.4404	NM_002869
RAB6A	hsa-miR-186-5p	85.3505	NM_002869
RAB6A	hsa-miR-765	85.2146	NM_002869
RAB6A	hsa-miR-5585-5p	84.4123	NM_002869
RAB6A	hsa-miR-3658	84.3525	NM_002869
RAB6A	hsa-miR-299-3p	83.6119	NM_002869
RAB6A	hsa-miR-219b-3p	83.3258	NM_002869
RAB6A	hsa-miR-6128	82.4108	NM_002869
RAB6A	hsa-miR-2052	81.6868	NM_002869
RAB6A	hsa-miR-4659a-5p	81.2321	NM_002869

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Motifs and transcription factors (TFs) regulating RAB6A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RAB6A	transfac_pro__M06035	ZNF749 (directAnnotation).
RAB6A	transfac_pro__M01861	ATF1 (directAnnotation).
RAB6A	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
RAB6A	jaspar__MA1596.1	ZNF460 (directAnnotation).
RAB6A	metacluster_52.11	ZNF184 (directAnnotation).
RAB6A	metacluster_35.7	HINFP (inferredBy_Orthology).
RAB6A	metacluster_98.1	ZNF524 (directAnnotation).
RAB6A	metacluster_135.11	NR2C2 (directAnnotation).
RAB6A	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
RAB6A	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
RAB6A	metacluster_7.13	ZFX (directAnnotation).
RAB6A	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
RAB6A	cisbp__M00968	MTF2 (directAnnotation).
RAB6A	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
RAB6A	metacluster_160.20	JUND; PRDM15 (directAnnotation).
RAB6A	cisbp__M00341	PAX6 (directAnnotation).
RAB6A	metacluster_198.3	ZFP64 (directAnnotation).
RAB6A	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
RAB6A	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
RAB6A	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
RAB6A	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
RAB6A	cisbp__M00788	ZFY (inferredBy_Orthology).
RAB6A	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
RAB6A	metacluster_175.1	ZNF283 (directAnnotation).
RAB6A	hdpi__ZNF304	ZNF304 (directAnnotation).
RAB6A	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
RAB6A	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
RAB6A	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
RAB6A	transfac_pro__M01199	TRIM28 (directAnnotation).
RAB6A	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
RAB6A	metacluster_151.2	ZNF23 (directAnnotation).
RAB6A	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
RAB6A	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
RAB6A	transfac_pro__M03806	ZBTB7C (directAnnotation).
RAB6A	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."