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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RAB5B

Summary for RAB5B

Gene information	Gene symbol	RAB5B
	Ensembl ID	ENSG00000111540
	Entrez ID	5869
	Gene name	RAB5B, member RAS oncogene family
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	P61020

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Dataset with differentially expressed gene: RAB5B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.802472	2.87e-02
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.361689	2.76e-34
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	0.415599	0.00e+00

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Expression of RAB5B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RAB5B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RAB5B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RAB5B	hsa-miR-5011-5p	99.9951	NM_001252036
RAB5B	hsa-miR-190a-3p	99.8279	NM_001252036
RAB5B	hsa-miR-6852-5p	99.1731	NM_001252036
RAB5B	hsa-miR-369-3p	97.0843	NM_001252036
RAB5B	hsa-miR-6127	95.6907	NM_001252036
RAB5B	hsa-miR-3924	94.4506	NM_001252036
RAB5B	hsa-miR-3918	94.421	NM_001252036
RAB5B	hsa-miR-20a-5p	93.7054	NM_001252036
RAB5B	hsa-miR-106b-5p	93.7054	NM_001252036
RAB5B	hsa-miR-765	93.6425	NM_001252036
RAB5B	hsa-miR-11181-3p	93.5901	NM_001252036
RAB5B	hsa-miR-22-3p	93.4341	NM_001252036
RAB5B	hsa-miR-526b-3p	93.4305	NM_001252036
RAB5B	hsa-miR-17-5p	93.4305	NM_001252036
RAB5B	hsa-miR-106a-5p	93.4305	NM_001252036
RAB5B	hsa-miR-93-5p	93.4305	NM_001252036
RAB5B	hsa-miR-20b-5p	93.4305	NM_001252036
RAB5B	hsa-miR-519d-3p	93.4305	NM_001252036
RAB5B	hsa-miR-6129	92.8682	NM_001252036
RAB5B	hsa-miR-6130	92.8682	NM_001252036
RAB5B	hsa-miR-6133	92.8682	NM_001252036
RAB5B	hsa-miR-4510	92.8682	NM_001252036
RAB5B	hsa-miR-6739-5p	91.6956	NM_001252036
RAB5B	hsa-miR-6731-5p	91.571	NM_001252036
RAB5B	hsa-miR-8085	91.571	NM_001252036
RAB5B	hsa-miR-6079	91.3241	NM_001252036
RAB5B	hsa-miR-5194	91.1253	NM_001252036
RAB5B	hsa-miR-3922-5p	90.2907	NM_001252036
RAB5B	hsa-miR-6733-5p	90.187	NM_001252036
RAB5B	hsa-miR-149-3p	89.6677	NM_001252036
RAB5B	hsa-miR-12136	89.133	NM_001252036
RAB5B	hsa-miR-3153	88.6274	NM_001252036
RAB5B	hsa-miR-6847-5p	87.6256	NM_001252036
RAB5B	hsa-miR-6738-5p	86.9517	NM_001252036
RAB5B	hsa-miR-1914-3p	86.9517	NM_001252036
RAB5B	hsa-miR-6722-3p	86.6781	NM_001252036
RAB5B	hsa-miR-4667-3p	86.4747	NM_001252036
RAB5B	hsa-miR-6883-5p	86.2059	NM_001252036
RAB5B	hsa-miR-6783-5p	86.176	NM_001252036
RAB5B	hsa-miR-6887-5p	85.9766	NM_001252036
RAB5B	hsa-miR-6795-5p	85.9766	NM_001252036
RAB5B	hsa-miR-1286	85.2986	NM_001252036
RAB5B	hsa-miR-6785-5p	85.1415	NM_001252036
RAB5B	hsa-miR-4728-5p	85.1415	NM_001252036
RAB5B	hsa-miR-3127-5p	84.9244	NM_001252036
RAB5B	hsa-miR-4753-5p	84.8394	NM_001252036
RAB5B	hsa-miR-4252	84.7491	NM_001252036
RAB5B	hsa-miR-4714-3p	84.2792	NM_001252036
RAB5B	hsa-miR-6783-3p	83.6803	NM_001252036
RAB5B	hsa-miR-939-3p	83.3845	NM_001252036

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Motifs and transcription factors (TFs) regulating RAB5B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RAB5B	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
RAB5B	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
RAB5B	transfac_pro__M04617	ZBTB7A (directAnnotation).
RAB5B	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
RAB5B	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
RAB5B	swissregulon__hs__CHD1	CHD1 (directAnnotation).
RAB5B	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
RAB5B	transfac_pro__M03876	ZBTB33 (directAnnotation).
RAB5B	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
RAB5B	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
RAB5B	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
RAB5B	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
RAB5B	metacluster_7.13	ZFX (directAnnotation).
RAB5B	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
RAB5B	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
RAB5B	cisbp__M00788	ZFY (inferredBy_Orthology).
RAB5B	hdpi__ZNF304	ZNF304 (directAnnotation).
RAB5B	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
RAB5B	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
RAB5B	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
RAB5B	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_1	ELK1; GCM1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."