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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RAB4A

Summary for RAB4A

Gene information	Gene symbol	RAB4A
	Ensembl ID	ENSG00000168118
	Entrez ID	5867
	Gene name	RAB4A, member RAS oncogene family
	Synonyms	HRES-1/RAB4\|RAB4
	Gene type	protein_coding
	UniProtAcc	P20338

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Dataset with differentially expressed gene: RAB4A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	-0.308444	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.263756	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.355075	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.624862	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.467618	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.345965	0.00e+00

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Expression of RAB4A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RAB4A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RAB4A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RAB4A	hsa-miR-10b-3p	98.2047	NM_001271998
RAB4A	hsa-miR-101-3p	95.3996	NM_001271998
RAB4A	hsa-miR-217-5p	92.6008	NM_001271998
RAB4A	hsa-miR-6807-3p	92.102	NM_001271998
RAB4A	hsa-miR-5007-3p	89.6115	NM_001271998
RAB4A	hsa-miR-138-1-3p	88.2407	NM_001271998
RAB4A	hsa-miR-3910	88.0681	NM_001271998
RAB4A	hsa-miR-4797-5p	85.7725	NM_001271998
RAB4A	hsa-miR-3912-5p	85.4088	NM_001271998
RAB4A	hsa-miR-93-3p	85.2591	NM_001271998
RAB4A	hsa-miR-1250-3p	85.2269	NM_001271998
RAB4A	hsa-miR-1252-3p	84.8567	NM_001271998
RAB4A	hsa-miR-548e-5p	82.9053	NM_001271998
RAB4A	hsa-miR-6867-3p	82.5222	NM_001271998
RAB4A	hsa-miR-600	82.4618	NM_001271998
RAB4A	hsa-miR-3657	82.28	NM_001271998
RAB4A	hsa-miR-4293	80.8147	NM_001271998
RAB4A	hsa-miR-5581-3p	80.6926	NM_001271998
RAB4A	hsa-miR-1227-3p	80.3031	NM_001271998

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Motifs and transcription factors (TFs) regulating RAB4A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RAB4A	jaspar__MA1106.1	HIF1A (directAnnotation).
RAB4A	jaspar__MA1934.1	FIGLA (directAnnotation).
RAB4A	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
RAB4A	swissregulon__hs__ELF2	ELF2 (directAnnotation).
RAB4A	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
RAB4A	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
RAB4A	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
RAB4A	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
RAB4A	kznf__ZNF441_Imbeault2017_OM_RCADE	ZNF441 (directAnnotation).
RAB4A	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
RAB4A	transfac_pro__M04950	EGR1 (directAnnotation).
RAB4A	taipale_tf_pairs__ERF_HES7_NCCGGAANNNNNNCACGYGNN_CAP_repr	ERF; HES7 (directAnnotation).
RAB4A	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
RAB4A	transfac_pro__M02089	E2F3 (directAnnotation).
RAB4A	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
RAB4A	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
RAB4A	hdpi__HIP2	UBE2K (directAnnotation).
RAB4A	hdpi__NRL	NRL (directAnnotation).
RAB4A	transfac_pro__M00430	E2F1 (directAnnotation).
RAB4A	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
RAB4A	transfac_pro__M07329	SP7 (directAnnotation).
RAB4A	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
RAB4A	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
RAB4A	cisbp__M07938	E2F1 (directAnnotation).
RAB4A	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
RAB4A	transfac_pro__M07436	WT1 (directAnnotation).
RAB4A	metacluster_3.14	WT1; WT1 (directAnnotation).
RAB4A	transfac_pro__M01837	KLF11 (directAnnotation).
RAB4A	transfac_pro__M07310	SP5 (directAnnotation).
RAB4A	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
RAB4A	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
RAB4A	transfac_pro__M04817	ZBTB33 (directAnnotation).
RAB4A	swissregulon__hs__KLF6	KLF6 (directAnnotation).
RAB4A	metacluster_7.13	ZFX (directAnnotation).
RAB4A	transfac_pro__M00716	ZBTB14 (directAnnotation).
RAB4A	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
RAB4A	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
RAB4A	cisbp__M00968	MTF2 (directAnnotation).
RAB4A	metacluster_163.2	ZNF682 (directAnnotation).
RAB4A	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
RAB4A	transfac_pro__M04916	TAF1 (directAnnotation).
RAB4A	transfac_pro__M00938	E2F1 (directAnnotation).
RAB4A	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
RAB4A	transfac_pro__M02090	E2F4 (directAnnotation).
RAB4A	swissregulon__hs__CHD1	CHD1 (directAnnotation).
RAB4A	transfac_pro__M01303	SP1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."