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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RAB3GAP2

Summary for RAB3GAP2

Gene information	Gene symbol	RAB3GAP2
	Ensembl ID	ENSG00000118873
	Entrez ID	25782
	Gene name	RAB3 GTPase activating non-catalytic protein subunit 2
	Synonyms	DKFZP434D245\|KIAA0839\|RAB3-GAP150\|SPG69
	Gene type	protein_coding
	UniProtAcc	Q9H2M9

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Dataset with differentially expressed gene: RAB3GAP2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.360914	2.41e-26

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Expression of RAB3GAP2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RAB3GAP2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RAB3GAP2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RAB3GAP2	hsa-miR-12124	98.3436	NM_012414
RAB3GAP2	hsa-miR-3148	97.1715	NM_012414
RAB3GAP2	hsa-miR-4496	97.1141	NM_012414
RAB3GAP2	hsa-miR-323a-3p	95.2162	NM_012414
RAB3GAP2	hsa-miR-651-3p	94.8955	NM_012414
RAB3GAP2	hsa-miR-4502	93.7096	NM_012414
RAB3GAP2	hsa-miR-4282	92.1718	NM_012414
RAB3GAP2	hsa-miR-4666a-3p	90.802	NM_012414
RAB3GAP2	hsa-miR-3184-3p	90.4481	NM_012414
RAB3GAP2	hsa-miR-374a-5p	90.2792	NM_012414
RAB3GAP2	hsa-miR-374b-5p	89.7383	NM_012414
RAB3GAP2	hsa-miR-7157-5p	87.1933	NM_012414
RAB3GAP2	hsa-miR-4742-3p	86.8597	NM_012414
RAB3GAP2	hsa-miR-182-5p	86.3962	NM_012414
RAB3GAP2	hsa-miR-4310	86.2578	NM_012414
RAB3GAP2	hsa-let-7f-2-3p	85.6875	NM_012414
RAB3GAP2	hsa-miR-1185-2-3p	85.6875	NM_012414
RAB3GAP2	hsa-miR-1185-1-3p	85.6875	NM_012414
RAB3GAP2	hsa-miR-6815-3p	84.6421	NM_012414
RAB3GAP2	hsa-miR-548e-5p	84.5262	NM_012414
RAB3GAP2	hsa-let-7f-1-3p	84.4659	NM_012414
RAB3GAP2	hsa-let-7b-3p	84.4659	NM_012414
RAB3GAP2	hsa-miR-98-3p	84.4659	NM_012414
RAB3GAP2	hsa-let-7a-3p	84.4659	NM_012414
RAB3GAP2	hsa-miR-3664-5p	84.2596	NM_012414
RAB3GAP2	hsa-miR-183-3p	83.8492	NM_012414
RAB3GAP2	hsa-miR-5193	82.3423	NM_012414
RAB3GAP2	hsa-miR-1294	82.2272	NM_012414
RAB3GAP2	hsa-miR-4500	82.0927	NM_012414
RAB3GAP2	hsa-miR-8068	81.7773	NM_012414
RAB3GAP2	hsa-miR-590-3p	81.6526	NM_012414
RAB3GAP2	hsa-miR-4495	81.1285	NM_012414
RAB3GAP2	hsa-miR-5003-5p	80.7836	NM_012414
RAB3GAP2	hsa-miR-890	80.7568	NM_012414
RAB3GAP2	hsa-miR-9986	80.4578	NM_012414
RAB3GAP2	hsa-miR-205-3p	80.2749	NM_012414

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Motifs and transcription factors (TFs) regulating RAB3GAP2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RAB3GAP2	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."