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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: RAB3B

Summary for RAB3B

Gene informationGene symbol

RAB3B

Ensembl ID

ENSG00000169213

Entrez ID

5865

Gene nameRAB3B, member RAS oncogene family
SynonymsNA
Gene typeprotein_coding
UniProtAcc

P20337


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Dataset with differentially expressed gene: RAB3B

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE139386

H3122 cell lineCell lineLung cancerEML4-ALK fusion-positive non-small cell lung cancer (NSCLC)Targeted therapyceritinibNAMalignant cells-0.4069230.00e+00

GSE168668

LNCaP cell lineCell lineProstate cancerProstate cancerTargeted therapyenzalutamideNAMalignant cells-0.4973610.00e+00

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Expression of RAB3B in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to RAB3B

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RAB3B

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
RAB3Bhsa-miR-5011-5p100NM_002867
RAB3Bhsa-miR-190a-3p99.9986NM_002867
RAB3Bhsa-miR-806899.9663NM_002867
RAB3Bhsa-miR-6809-3p99.2603NM_002867
RAB3Bhsa-miR-1252-3p98.7265NM_002867
RAB3Bhsa-miR-4753-3p97.8303NM_002867
RAB3Bhsa-miR-627-3p97.7703NM_002867
RAB3Bhsa-miR-9983-3p97.1766NM_002867
RAB3Bhsa-miR-127595.974NM_002867
RAB3Bhsa-miR-444195.799NM_002867
RAB3Bhsa-miR-364695.5265NM_002867
RAB3Bhsa-miR-129-5p95.457NM_002867
RAB3Bhsa-miR-4665-5p94.7735NM_002867
RAB3Bhsa-miR-425293.7448NM_002867
RAB3Bhsa-miR-95-5p92.5892NM_002867
RAB3Bhsa-miR-4524a-3p92.5087NM_002867
RAB3Bhsa-miR-4701-5p91.5777NM_002867
RAB3Bhsa-miR-58891.5777NM_002867
RAB3Bhsa-miR-447090.8457NM_002867
RAB3Bhsa-miR-570090.4547NM_002867
RAB3Bhsa-miR-6778-3p90.3531NM_002867
RAB3Bhsa-miR-4743-3p89.9207NM_002867
RAB3Bhsa-miR-4652-3p89.6185NM_002867
RAB3Bhsa-miR-607289.3201NM_002867
RAB3Bhsa-miR-425188.8237NM_002867
RAB3Bhsa-miR-579-3p88.5993NM_002867
RAB3Bhsa-miR-664b-3p88.5993NM_002867
RAB3Bhsa-miR-4796-5p88.5864NM_002867
RAB3Bhsa-miR-431188.4271NM_002867
RAB3Bhsa-miR-361186.741NM_002867
RAB3Bhsa-miR-427085.5103NM_002867
RAB3Bhsa-miR-6754-5p85.4815NM_002867
RAB3Bhsa-miR-6891-3p85.3218NM_002867
RAB3Bhsa-miR-335-5p85.044NM_002867
RAB3Bhsa-miR-6823-3p84.7005NM_002867
RAB3Bhsa-miR-892a84.5381NM_002867
RAB3Bhsa-miR-442584.519NM_002867
RAB3Bhsa-miR-10395-3p84.4581NM_002867
RAB3Bhsa-miR-3691-3p84.3798NM_002867
RAB3Bhsa-miR-451184.0788NM_002867
RAB3Bhsa-miR-194-5p83.7166NM_002867
RAB3Bhsa-miR-660-3p83.5128NM_002867
RAB3Bhsa-miR-569683.1167NM_002867
RAB3Bhsa-miR-2114-3p82.758NM_002867
RAB3Bhsa-miR-607182.0827NM_002867
RAB3Bhsa-miR-5088-3p82.07NM_002867
RAB3Bhsa-miR-138-1-3p82.0608NM_002867
RAB3Bhsa-miR-5089-5p82.0403NM_002867
RAB3Bhsa-miR-942-5p81.8924NM_002867
RAB3Bhsa-miR-6721-5p81.648NM_002867
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Motifs and transcription factors (TFs) regulating RAB3B

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
RAB3Btaipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_reprE2F1; ELK1 (directAnnotation).
RAB3Bjaspar__MA1122.1TFDP1 (directAnnotation).
RAB3Bswissregulon__hs__ZBTB14ZBTB14 (directAnnotation).
RAB3Bkznf__ZBTB14_Schmitges2016_RCADEZBTB14 (directAnnotation).
RAB3Btransfac_pro__M02089E2F3 (directAnnotation).
RAB3Btaipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_methE2F2 (directAnnotation).
RAB3Bmetacluster_143.13ZBTB7A (directAnnotation).
RAB3Bmetacluster_15.1E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
RAB3Bmetacluster_15.2E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."