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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RAB28

Summary for RAB28

Gene information	Gene symbol	RAB28
	Ensembl ID	ENSG00000157869
	Entrez ID	9364
	Gene name	RAB28, member RAS oncogene family
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: RAB28

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.304029	0.00e+00

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Expression of RAB28 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RAB28

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RAB28

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RAB28	hsa-miR-338-5p	98.6687	NM_001159601
RAB28	hsa-miR-4452	96.5277	NM_001017979
RAB28	hsa-miR-7113-5p	94.7619	NM_001017979
RAB28	hsa-miR-498-5p	94.376	NM_001159601
RAB28	hsa-miR-181b-2-3p	93.9513	NM_001159601
RAB28	hsa-miR-181b-3p	93.9513	NM_001159601
RAB28	hsa-miR-4666a-3p	93.0233	NM_001159601
RAB28	hsa-miR-10397-5p	92.9751	NM_004249
RAB28	hsa-miR-4420	92.8923	NM_001159601
RAB28	hsa-miR-4316	90.0883	NM_001017979
RAB28	hsa-miR-4763-5p	89.8251	NM_001159601
RAB28	hsa-miR-3908	85.8412	NM_001017979
RAB28	hsa-miR-3662	85.5883	NM_001017979
RAB28	hsa-miR-4482-3p	85.5467	NM_001017979
RAB28	hsa-miR-3646	84.8549	NM_001017979
RAB28	hsa-miR-10393-5p	83.5348	NM_001017979
RAB28	hsa-miR-361-5p	83.2756	NM_001017979
RAB28	hsa-miR-12113	83.1624	NM_004249
RAB28	hsa-miR-7151-3p	83.0806	NM_001017979
RAB28	hsa-miR-642b-3p	82.0773	NM_001017979
RAB28	hsa-miR-642a-3p	82.0773	NM_001017979
RAB28	hsa-miR-4798-3p	81.9348	NM_001017979
RAB28	hsa-miR-4539	81.6299	NM_004249

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Motifs and transcription factors (TFs) regulating RAB28

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RAB28	transfac_pro__M04950	EGR1 (directAnnotation).
RAB28	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
RAB28	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
RAB28	taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_repr	ERF; HES7 (directAnnotation).
RAB28	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
RAB28	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
RAB28	transfac_pro__M00652	NRF1 (directAnnotation).
RAB28	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
RAB28	transfac_pro__M04866	HDAC2 (directAnnotation).
RAB28	jaspar__MA1122.1	TFDP1 (directAnnotation).
RAB28	metacluster_34.1	ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).
RAB28	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
RAB28	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."