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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RAB27A

Summary for RAB27A

Gene information	Gene symbol	RAB27A
	Ensembl ID	ENSG00000069974
	Entrez ID	5873
	Gene name	RAB27A, member RAS oncogene family
	Synonyms	GS2\|HsT18676\|RAB27\|RAM
	Gene type	protein_coding
	UniProtAcc	P51159

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Dataset with differentially expressed gene: RAB27A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-1.05053	2.49e-02
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.32036	2.64e-16
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD8+ T cells	-0.319064	9.03e-09
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.491991	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	0.286971	5.80e-32
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.333216	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.461585	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.593612	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.420975	2.83e-28

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Expression of RAB27A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RAB27A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
RAB27A	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating RAB27A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RAB27A	hsa-miR-3121-3p	98.4375	NM_004580
RAB27A	hsa-miR-3714	97.7247	NM_004580
RAB27A	hsa-miR-506-3p	97.568	NM_004580
RAB27A	hsa-miR-124-3p	97.568	NM_004580
RAB27A	hsa-miR-3118	95.88	NM_004580
RAB27A	hsa-miR-134-5p	95.88	NM_004580
RAB27A	hsa-miR-3910	93.5043	NM_004580
RAB27A	hsa-miR-494-3p	92.1374	NM_004580
RAB27A	hsa-miR-3156-5p	91.5927	NM_004580
RAB27A	hsa-miR-96-5p	90.2596	NM_004580
RAB27A	hsa-miR-12133	89.9373	NM_004580
RAB27A	hsa-miR-1271-5p	89.9373	NM_004580
RAB27A	hsa-miR-302c-5p	85.7239	NM_004580
RAB27A	hsa-miR-760	85.7011	NM_004580
RAB27A	hsa-miR-6839-5p	85.6958	NM_004580
RAB27A	hsa-miR-6504-3p	85.1616	NM_004580
RAB27A	hsa-miR-4699-3p	85.0018	NM_004580
RAB27A	hsa-miR-6732-5p	84.9396	NM_004580
RAB27A	hsa-miR-2355-3p	84.4844	NM_004580
RAB27A	hsa-miR-4781-5p	83.6583	NM_004580
RAB27A	hsa-miR-5187-3p	82.6658	NM_004580
RAB27A	hsa-miR-8057	81.5371	NM_004580
RAB27A	hsa-miR-378j	80.088	NM_004580

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Motifs and transcription factors (TFs) regulating RAB27A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RAB27A	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
RAB27A	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
RAB27A	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
RAB27A	transfac_pro__M04826	EP300 (directAnnotation).
RAB27A	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
RAB27A	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
RAB27A	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
RAB27A	jaspar__MA1122.1	TFDP1 (directAnnotation).
RAB27A	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
RAB27A	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
RAB27A	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
RAB27A	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
RAB27A	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
RAB27A	metacluster_55.5	ZNF541 (directAnnotation).
RAB27A	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
RAB27A	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
RAB27A	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP	ERG; TEAD4 (directAnnotation).
RAB27A	transfac_pro__M06032	ZNF727 (directAnnotation).
RAB27A	taipale_tf_pairs__ETV2_FOXI1_RNCGGAANNAAACA_CAP_repr	ETV2; FOXI1 (directAnnotation).
RAB27A	taipale_tf_pairs__ERF_TBX21_TMACACCGGAAG_CAP	ERF; TBX21 (directAnnotation).
RAB27A	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
RAB27A	taipale_tf_pairs__ETV2_PITX1_RSCGGAANNNNNGGMTTAN_CAP	ETV2; PITX1 (directAnnotation).
RAB27A	hdpi__ELF2	ELF2 (directAnnotation).
RAB27A	swissregulon__hs__ELK1	ELK1 (directAnnotation).
RAB27A	metacluster_183.4	ETS1 (inferredBy_Orthology).
RAB27A	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).
RAB27A	taipale_tf_pairs__ETV5_EOMES_TNRCACCGGAWN_CAP	EOMES; ETV5 (directAnnotation).
RAB27A	taipale_tf_pairs__ETV5_HOXB13_NNCGGANGNNNTWAA_CAP	ETV5; HOXB13 (directAnnotation).
RAB27A	transfac_pro__M05393	ZBTB6 (inferredBy_Orthology).
RAB27A	hocomoco__BPTF_HUMAN.H11MO.0.D	BPTF (directAnnotation).
RAB27A	tfdimers__MD00521	CHURC1; TAF6; TBP (directAnnotation).
RAB27A	tfdimers__MD00425	ELF5; SMAD4 (directAnnotation).
RAB27A	taipale_tf_pairs__ELK1_FOXI1_RSCGGAANNRTMAAYAN_CAP_repr	ELK1; FOXI1 (directAnnotation).
RAB27A	metacluster_85.1	FOXH1; ZNF8; ZNF8 (directAnnotation).
RAB27A	metacluster_16.6	SOX1; SOX14; SOX15; SOX18; SOX2; SOX2; SOX8; SRY (directAnnotation). SOX1; SOX10; SOX17; SOX3 (inferredBy_Orthology).
RAB27A	transfac_pro__M04622	NR4A1 (directAnnotation).
RAB27A	metacluster_26.10	SOX21; SOX7; SOX8 (directAnnotation).
RAB27A	transfac_pro__M05406	ZNF781 (directAnnotation).
RAB27A	tfdimers__MD00033	ATF1; ATF2; ATF3; ATF4; ATF7; CREB1; CREM; YY1 (directAnnotation).
RAB27A	taipale_tf_pairs__GCM1_ETV7_NTNNNGGCGGAAGNNNTTCCNNN_CAP_repr	ETV7; GCM1 (directAnnotation).
RAB27A	transfac_pro__M12697	ZNF142 (directAnnotation).
RAB27A	transfac_pro__M06173	ZNF85 (directAnnotation).
RAB27A	jaspar__MA1650.1	ZBTB14 (directAnnotation).
RAB27A	transfac_pro__M02089	E2F3 (directAnnotation).
RAB27A	transfac_pro__M03806	ZBTB7C (directAnnotation).
RAB27A	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
RAB27A	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
RAB27A	tfdimers__MD00483	ZBTB14 (directAnnotation).
RAB27A	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
RAB27A	transfac_pro__M06085	ZNF26 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."