Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RAB21

Summary for RAB21

Gene information	Gene symbol	RAB21
	Ensembl ID	ENSG00000080371
	Entrez ID	23011
	Gene name	RAB21, member RAS oncogene family
	Synonyms	KIAA0118
	Gene type	protein_coding
	UniProtAcc	Q9UL25

Top

Dataset with differentially expressed gene: RAB21

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.39934	1.91e-37
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.321314	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.280759	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.461363	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.326114	1.20e-21
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.267538	0.00e+00

Top

Expression of RAB21 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to RAB21

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating RAB21

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RAB21	hsa-miR-3613-3p	99.9983	NM_014999
RAB21	hsa-miR-3646	99.7646	NM_014999
RAB21	hsa-miR-4753-5p	99.5427	NM_014999
RAB21	hsa-miR-6768-3p	99.1401	NM_014999
RAB21	hsa-miR-3662	99.0567	NM_014999
RAB21	hsa-miR-4686	98.7672	NM_014999
RAB21	hsa-miR-186-5p	97.8852	NM_014999
RAB21	hsa-miR-548e-5p	97.5652	NM_014999
RAB21	hsa-miR-6083	97.4553	NM_014999
RAB21	hsa-miR-616-5p	97.2096	NM_014999
RAB21	hsa-miR-373-5p	97.2096	NM_014999
RAB21	hsa-miR-371b-5p	97.2096	NM_014999
RAB21	hsa-miR-548aw	97.1969	NM_014999
RAB21	hsa-miR-9902	96.8187	NM_014999
RAB21	hsa-miR-548l	95.8104	NM_014999
RAB21	hsa-miR-4760-3p	95.4849	NM_014999
RAB21	hsa-miR-380-3p	95.305	NM_014999
RAB21	hsa-miR-2053	95.101	NM_014999
RAB21	hsa-miR-4495	94.9717	NM_014999
RAB21	hsa-miR-3973	94.925	NM_014999
RAB21	hsa-miR-520h	94.7814	NM_014999
RAB21	hsa-miR-520g-3p	94.7814	NM_014999
RAB21	hsa-miR-5011-5p	94.1848	NM_014999
RAB21	hsa-miR-302f	94.1622	NM_014999
RAB21	hsa-miR-3942-3p	94.1534	NM_014999
RAB21	hsa-miR-7106-5p	93.7846	NM_014999
RAB21	hsa-miR-548an	92.7994	NM_014999
RAB21	hsa-miR-200b-3p	92.5043	NM_014999
RAB21	hsa-miR-200c-3p	92.5043	NM_014999
RAB21	hsa-miR-429	92.5043	NM_014999
RAB21	hsa-miR-3128	92.3962	NM_014999
RAB21	hsa-miR-3133	92.0206	NM_014999
RAB21	hsa-miR-1297	91.9374	NM_014999
RAB21	hsa-miR-3674	91.7325	NM_014999
RAB21	hsa-miR-205-3p	90.7447	NM_014999
RAB21	hsa-miR-302c-5p	90.049	NM_014999
RAB21	hsa-miR-548p	89.8788	NM_014999
RAB21	hsa-miR-548g-5p	89.8568	NM_014999
RAB21	hsa-miR-548x-5p	89.8568	NM_014999
RAB21	hsa-miR-548f-5p	89.8568	NM_014999
RAB21	hsa-miR-548aj-5p	89.8568	NM_014999
RAB21	hsa-miR-1468-3p	89.3462	NM_014999
RAB21	hsa-miR-183-5p	89.2221	NM_014999
RAB21	hsa-miR-670-3p	88.6145	NM_014999
RAB21	hsa-miR-5003-3p	88.5534	NM_014999
RAB21	hsa-miR-627-3p	88.2459	NM_014999
RAB21	hsa-miR-26b-5p	88.1918	NM_014999
RAB21	hsa-miR-26a-5p	88.1918	NM_014999
RAB21	hsa-miR-548au-3p	87.8914	NM_014999
RAB21	hsa-miR-585-5p	87.8708	NM_014999

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating RAB21

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RAB21	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
RAB21	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
RAB21	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
RAB21	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
RAB21	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
RAB21	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
RAB21	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
RAB21	metacluster_3.14	WT1; WT1 (directAnnotation).
RAB21	metacluster_135.11	NR2C2 (directAnnotation).
RAB21	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
RAB21	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
RAB21	metacluster_7.13	ZFX (directAnnotation).
RAB21	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
RAB21	cisbp__M00968	MTF2 (directAnnotation).
RAB21	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
RAB21	metacluster_160.20	JUND; PRDM15 (directAnnotation).
RAB21	cisbp__M00341	PAX6 (directAnnotation).
RAB21	metacluster_198.3	ZFP64 (directAnnotation).
RAB21	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
RAB21	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
RAB21	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
RAB21	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
RAB21	cisbp__M00788	ZFY (inferredBy_Orthology).
RAB21	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
RAB21	metacluster_175.1	ZNF283 (directAnnotation).
RAB21	hdpi__ZNF304	ZNF304 (directAnnotation).
RAB21	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
RAB21	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
RAB21	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
RAB21	transfac_pro__M01199	TRIM28 (directAnnotation).
RAB21	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
RAB21	metacluster_151.2	ZNF23 (directAnnotation).
RAB21	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
RAB21	transfac_pro__M03806	ZBTB7C (directAnnotation).
RAB21	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
RAB21	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
RAB21	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
RAB21	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
RAB21	cisbp__M01863	ZNF711 (inferredBy_Orthology).
RAB21	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
RAB21	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
RAB21	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
RAB21	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
RAB21	transfac_pro__M02913	SP140 (inferredBy_Orthology).
RAB21	jaspar__MA0748.2	YY2 (directAnnotation).
RAB21	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
RAB21	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
RAB21	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
RAB21	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
RAB21	transfac_pro__M00430	E2F1 (directAnnotation).

Page: 1 2 3

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."