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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RAB1B

Summary for RAB1B

Gene information	Gene symbol	RAB1B
	Ensembl ID	ENSG00000174903
	Entrez ID	81876
	Gene name	RAB1B, member RAS oncogene family
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: RAB1B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.614071	0.00e+00
GSE164237	patients	Peripheral blood mononuclear cells	Melanoma	Advanced stages of melanoma	Immunotherapy	pembrolizumab	pre	CD8+ T cells	-0.270883	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-1.12086	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.286548	0.00e+00

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Expression of RAB1B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RAB1B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RAB1B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RAB1B	hsa-miR-6841-3p	97.8901	NM_030981
RAB1B	hsa-miR-2355-5p	97.5341	NM_030981
RAB1B	hsa-miR-6721-5p	95.8325	NM_030981
RAB1B	hsa-miR-1207-5p	93.7266	NM_030981
RAB1B	hsa-miR-4763-3p	92.2429	NM_030981
RAB1B	hsa-miR-6735-5p	90.3653	NM_030981
RAB1B	hsa-miR-6879-5p	90.3653	NM_030981
RAB1B	hsa-miR-6836-5p	90.1259	NM_030981
RAB1B	hsa-miR-6132	90.1259	NM_030981
RAB1B	hsa-miR-1343-5p	89.2129	NM_030981
RAB1B	hsa-miR-939-5p	89.2129	NM_030981
RAB1B	hsa-miR-7843-5p	89.0021	NM_030981
RAB1B	hsa-miR-4632-5p	89.0021	NM_030981
RAB1B	hsa-miR-4436b-3p	88.4087	NM_030981
RAB1B	hsa-miR-654-5p	86.9984	NM_030981
RAB1B	hsa-miR-541-3p	86.9984	NM_030981
RAB1B	hsa-miR-103a-3p	86.1913	NM_030981
RAB1B	hsa-miR-107	86.1913	NM_030981
RAB1B	hsa-miR-4640-5p	85.8736	NM_030981
RAB1B	hsa-miR-1909-3p	83.745	NM_030981
RAB1B	hsa-miR-6722-3p	83.745	NM_030981
RAB1B	hsa-miR-502-5p	82.9001	NM_030981
RAB1B	hsa-miR-4726-5p	82.6863	NM_030981
RAB1B	hsa-miR-6895-5p	82.3153	NM_030981
RAB1B	hsa-miR-4485-5p	81.9169	NM_030981
RAB1B	hsa-miR-4775	81.806	NM_030981
RAB1B	hsa-miR-4692	81.5889	NM_030981
RAB1B	hsa-miR-7110-5p	81.0744	NM_030981
RAB1B	hsa-miR-6842-5p	81.0744	NM_030981
RAB1B	hsa-miR-452-3p	80.7495	NM_030981
RAB1B	hsa-miR-1915-5p	80.6126	NM_030981
RAB1B	hsa-miR-6764-5p	80.0447	NM_030981

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Motifs and transcription factors (TFs) regulating RAB1B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RAB1B	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
RAB1B	jaspar__MA1483.2	ELF2 (directAnnotation).
RAB1B	transfac_pro__M05628	ZNF735 (directAnnotation).
RAB1B	transfac_pro__M04826	EP300 (directAnnotation).
RAB1B	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
RAB1B	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
RAB1B	metacluster_34.4	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
RAB1B	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
RAB1B	cisbp__M08198	ELF1 (directAnnotation).
RAB1B	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
RAB1B	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
RAB1B	taipale_tf_pairs__TEAD4_HOXA13_RCATWCCNNNNNNTTTAYNNN_CAP_repr	HOXA13; TEAD4 (directAnnotation).
RAB1B	tfdimers__MD00370	YY1; ZNF384 (directAnnotation).
RAB1B	homer__ACAGGATGTGGT_ETS_RUNX	RUNX1 (directAnnotation).
RAB1B	tfdimers__MD00342	IRF1; YY1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."