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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RAB18

Summary for RAB18

Gene information	Gene symbol	RAB18
	Ensembl ID	ENSG00000099246
	Entrez ID	22931
	Gene name	RAB18, member RAS oncogene family
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: RAB18

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-0.665676	1.09e-05
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.277443	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.300423	1.17e-15
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.398834	2.93e-17
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.326146	1.09e-14
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.281769	0.00e+00

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Expression of RAB18 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RAB18

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RAB18

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RAB18	hsa-miR-10527-5p	99.0707	NM_001256410
RAB18	hsa-miR-3163	98.9508	NM_001256410
RAB18	hsa-miR-548ax	98.548	NM_001256411
RAB18	hsa-miR-548ao-5p	98.548	NM_001256411
RAB18	hsa-miR-1185-1-3p	96.9896	NM_001256410
RAB18	hsa-let-7f-2-3p	96.9896	NM_001256410
RAB18	hsa-miR-1185-2-3p	96.9896	NM_001256410
RAB18	hsa-miR-3065-5p	95.2788	NM_001256411
RAB18	hsa-miR-4284	94.166	NM_001256411
RAB18	hsa-miR-221-3p	94.0602	NM_001256410
RAB18	hsa-miR-222-3p	94.0602	NM_001256410
RAB18	hsa-miR-4503	94.0084	NM_001256411
RAB18	hsa-miR-7159-5p	93.3934	NM_001256411
RAB18	hsa-miR-643	93.0768	NM_001256411
RAB18	hsa-miR-548v	91.6822	NM_001256410
RAB18	hsa-miR-5688	91.0118	NM_001256411
RAB18	hsa-miR-19a-3p	90.9013	NM_001256410
RAB18	hsa-miR-19b-3p	90.9013	NM_001256410
RAB18	hsa-miR-3662	90.2727	NM_001256411
RAB18	hsa-miR-548e-5p	90.0214	NM_001256411
RAB18	hsa-miR-6792-5p	90.0048	NM_001256410
RAB18	hsa-miR-495-3p	89.4506	NM_001256411
RAB18	hsa-miR-589-3p	87.1606	NM_001256410
RAB18	hsa-miR-551b-5p	86.2883	NM_001256411
RAB18	hsa-miR-6859-5p	86.242	NM_001256411
RAB18	hsa-miR-3125	86.242	NM_001256411
RAB18	hsa-miR-3916	86.242	NM_001256411
RAB18	hsa-miR-1290	86.0907	NM_001256411
RAB18	hsa-miR-583	85.9233	NM_001256411
RAB18	hsa-miR-892c-5p	85.8606	NM_001256410
RAB18	hsa-miR-4760-3p	85.4163	NM_001256410
RAB18	hsa-miR-320d	85.0362	NM_001256411
RAB18	hsa-miR-4429	85.0362	NM_001256411
RAB18	hsa-miR-320b	85.0362	NM_001256411
RAB18	hsa-miR-320c	85.0362	NM_001256411
RAB18	hsa-miR-320a-3p	85.0362	NM_001256411
RAB18	hsa-miR-671-5p	84.0875	NM_001256411
RAB18	hsa-miR-548p	83.1838	NM_001256411
RAB18	hsa-miR-6074	83.0138	NM_001256411
RAB18	hsa-miR-4745-5p	82.123	NM_001256411
RAB18	hsa-miR-3192-3p	81.7788	NM_001256410
RAB18	hsa-miR-9986	81.4865	NM_001256411
RAB18	hsa-miR-1294	81.4865	NM_001256411
RAB18	hsa-miR-4289	81.1492	NM_001256410
RAB18	hsa-miR-7-2-3p	81.0664	NM_001256411
RAB18	hsa-miR-7-1-3p	81.0664	NM_001256411
RAB18	hsa-miR-2115-3p	80.3715	NM_001256411
RAB18	hsa-miR-190a-3p	80.3101	NM_001256410
RAB18	hsa-miR-7110-5p	80.2748	NM_001256411
RAB18	hsa-miR-6842-5p	80.2748	NM_001256411

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Motifs and transcription factors (TFs) regulating RAB18

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RAB18	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
RAB18	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
RAB18	transfac_pro__M04950	EGR1 (directAnnotation).
RAB18	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
RAB18	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
RAB18	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
RAB18	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
RAB18	transfac_pro__M00652	NRF1 (directAnnotation).
RAB18	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
RAB18	jaspar__MA1122.1	TFDP1 (directAnnotation).
RAB18	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
RAB18	transfac_pro__M04826	EP300 (directAnnotation).
RAB18	hdpi__TP73	TP73 (directAnnotation).
RAB18	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
RAB18	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
RAB18	swissregulon__hs__ELK1	ELK1 (directAnnotation).
RAB18	metacluster_81.7	CREB1 (directAnnotation).
RAB18	hdpi__ELF2	ELF2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."