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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PWWP2A

Summary for PWWP2A

Gene information	Gene symbol	PWWP2A
	Ensembl ID	ENSG00000170234
	Entrez ID	114825
	Gene name	PWWP domain containing 2A
	Synonyms	KIAA1935
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: PWWP2A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.531353	3.08e-02

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Expression of PWWP2A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PWWP2A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PWWP2A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PWWP2A	hsa-miR-5011-5p	99.9733	NM_001130864
PWWP2A	hsa-miR-190a-3p	99.739	NM_001130864
PWWP2A	hsa-miR-3163	99.4828	NM_052927
PWWP2A	hsa-miR-4795-3p	99.2411	NM_052927
PWWP2A	hsa-miR-29b-1-5p	98.8553	NM_052927
PWWP2A	hsa-miR-3143	97.4774	NM_052927
PWWP2A	hsa-miR-6074	95.5076	NM_052927
PWWP2A	hsa-miR-302d-5p	95.4584	NM_052927
PWWP2A	hsa-miR-302b-5p	95.4584	NM_052927
PWWP2A	hsa-miR-4659a-3p	94.3238	NM_052927
PWWP2A	hsa-miR-4659b-3p	94.3238	NM_052927
PWWP2A	hsa-miR-3682-5p	93.1785	NM_052927
PWWP2A	hsa-miR-6853-3p	91.9603	NM_001130864
PWWP2A	hsa-miR-922	91.458	NM_052927
PWWP2A	hsa-miR-6875-3p	91.2024	NM_052927
PWWP2A	hsa-miR-548c-3p	90.7325	NM_052927
PWWP2A	hsa-miR-3941	90.7026	NM_001130864
PWWP2A	hsa-miR-6516-5p	90.0093	NM_052927
PWWP2A	hsa-miR-126-5p	89.7786	NM_052927
PWWP2A	hsa-miR-15a-3p	89.7341	NM_052927
PWWP2A	hsa-miR-4328	88.7409	NM_052927
PWWP2A	hsa-miR-597-5p	87.0276	NM_001130864
PWWP2A	hsa-miR-1283	86.9771	NM_052927
PWWP2A	hsa-miR-466	86.7139	NM_001130864
PWWP2A	hsa-miR-1261	86.5441	NM_052927
PWWP2A	hsa-miR-302c-5p	86.4966	NM_052927
PWWP2A	hsa-miR-138-5p	86.3649	NM_052927
PWWP2A	hsa-miR-4672	86.1554	NM_001130864
PWWP2A	hsa-miR-3908	86.0054	NM_052927
PWWP2A	hsa-miR-4279	85.6633	NM_052927
PWWP2A	hsa-miR-532-5p	85.4015	NM_052927
PWWP2A	hsa-miR-570-5p	85.3301	NM_001130864
PWWP2A	hsa-miR-548ba	85.3301	NM_001130864
PWWP2A	hsa-miR-548ag	85.3301	NM_001130864
PWWP2A	hsa-miR-548ai	85.3301	NM_001130864
PWWP2A	hsa-miR-488-3p	85.3086	NM_052927
PWWP2A	hsa-miR-1323	85.06	NM_052927
PWWP2A	hsa-miR-4256	83.706	NM_001130864
PWWP2A	hsa-miR-11181-5p	83.706	NM_001130864
PWWP2A	hsa-miR-548o-3p	83.2795	NM_052927
PWWP2A	hsa-miR-4291	82.5454	NM_052927
PWWP2A	hsa-miR-4699-5p	82.2679	NM_052927
PWWP2A	hsa-miR-937-5p	82.2334	NM_052927
PWWP2A	hsa-miR-4264	81.6215	NM_001130864
PWWP2A	hsa-miR-617	81.2	NM_001130864
PWWP2A	hsa-miR-329-5p	80.8606	NM_052927
PWWP2A	hsa-miR-4275	80.632	NM_001130864
PWWP2A	hsa-miR-3618	80.4114	NM_052927

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Motifs and transcription factors (TFs) regulating PWWP2A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PWWP2A	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
PWWP2A	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
PWWP2A	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
PWWP2A	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
PWWP2A	transfac_pro__M04617	ZBTB7A (directAnnotation).
PWWP2A	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
PWWP2A	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
PWWP2A	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
PWWP2A	transfac_pro__M07387	ZBTB7A (directAnnotation).
PWWP2A	transfac_pro__M07436	WT1 (directAnnotation).
PWWP2A	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
PWWP2A	transfac_pro__M00716	ZBTB14 (directAnnotation).
PWWP2A	swissregulon__hs__CHD1	CHD1 (directAnnotation).
PWWP2A	hdpi__HIP2	UBE2K (directAnnotation).
PWWP2A	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
PWWP2A	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
PWWP2A	transfac_pro__M04893	TAF1 (directAnnotation).
PWWP2A	transfac_pro__M03876	ZBTB33 (directAnnotation).
PWWP2A	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
PWWP2A	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
PWWP2A	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
PWWP2A	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
PWWP2A	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."