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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PUS7

Summary for PUS7

Gene information	Gene symbol	PUS7
	Ensembl ID	ENSG00000091127
	Entrez ID	54517
	Gene name	pseudouridine synthase 7
	Synonyms	FLJ20485
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: PUS7

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-0.888104	6.77e-03

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Expression of PUS7 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PUS7

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PUS7

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PUS7	hsa-miR-4503	96.6398	NM_001318163
PUS7	hsa-let-7c-3p	96.4959	NM_001318163
PUS7	hsa-miR-524-5p	93.847	NM_001318163
PUS7	hsa-miR-520d-5p	93.847	NM_001318163
PUS7	hsa-miR-548x-3p	92.0916	NM_001318163
PUS7	hsa-miR-548aj-3p	92.0916	NM_001318163
PUS7	hsa-miR-376b-3p	90.9493	NM_001318163
PUS7	hsa-miR-376a-3p	90.9493	NM_001318163
PUS7	hsa-miR-548ae-3p	90.9388	NM_001318163
PUS7	hsa-miR-548aq-3p	90.9388	NM_001318163
PUS7	hsa-miR-548j-3p	90.9388	NM_001318163
PUS7	hsa-miR-548ah-3p	90.9388	NM_001318163
PUS7	hsa-miR-548am-3p	90.9388	NM_001318163
PUS7	hsa-miR-3177-5p	90.8661	NM_001318163
PUS7	hsa-miR-4708-3p	90.6699	NM_001318163
PUS7	hsa-miR-4303	89.3325	NM_001318163
PUS7	hsa-miR-6804-3p	88.2807	NM_001318163
PUS7	hsa-miR-498-3p	87.9491	NM_001318163
PUS7	hsa-miR-548an	87.5384	NM_001318163
PUS7	hsa-miR-548aw	86.6185	NM_001318163
PUS7	hsa-miR-610	84.79	NM_001318163
PUS7	hsa-miR-519a-2-5p	84.78	NM_001318163
PUS7	hsa-miR-520b-5p	84.78	NM_001318163
PUS7	hsa-miR-3910	84.5289	NM_001318163
PUS7	hsa-miR-527	83.5541	NM_001318163
PUS7	hsa-miR-518a-5p	83.5541	NM_001318163
PUS7	hsa-miR-92b-3p	82.5804	NM_001318163
PUS7	hsa-miR-92a-3p	82.5804	NM_001318163
PUS7	hsa-miR-32-5p	82.5804	NM_001318163
PUS7	hsa-miR-6876-3p	82.2086	NM_001318163
PUS7	hsa-miR-626	82.2086	NM_001318163
PUS7	hsa-miR-3664-3p	80.0491	NM_001318163

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Motifs and transcription factors (TFs) regulating PUS7

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."