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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: PURB

Summary for PURB

Gene informationGene symbol

PURB

Ensembl ID

ENSG00000146676

Entrez ID

5814

Gene namepurine rich element binding protein B
SynonymsPURBETA
Gene typeprotein_coding
UniProtAcc

Q96QR8


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Dataset with differentially expressed gene: PURB

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE131984_JQ1Pal

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)Targeted therapyJQ1 + palbociclibNAMalignant cells0.5045271.36e-39

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Expression of PURB in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to PURB

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PURB

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
PURBhsa-miR-101-3p99.1702NM_033224
PURBhsa-miR-467297.7525NM_033224
PURBhsa-miR-365897.6366NM_033224
PURBhsa-miR-548c-3p96.5165NM_033224
PURBhsa-miR-20a-5p96.2731NM_033224
PURBhsa-miR-106b-5p96.2731NM_033224
PURBhsa-miR-60796.0472NM_033224
PURBhsa-miR-548ar-3p95.9451NM_033224
PURBhsa-miR-4742-3p95.7848NM_033224
PURBhsa-miR-6861-5p95.5363NM_033224
PURBhsa-miR-466095.4349NM_033224
PURBhsa-miR-397895.3587NM_033224
PURBhsa-miR-128695.2254NM_033224
PURBhsa-miR-3140-3p95.1369NM_033224
PURBhsa-miR-17-5p94.999NM_033224
PURBhsa-miR-93-5p94.999NM_033224
PURBhsa-miR-106a-5p94.999NM_033224
PURBhsa-miR-526b-3p94.999NM_033224
PURBhsa-miR-519d-3p94.999NM_033224
PURBhsa-miR-20b-5p94.999NM_033224
PURBhsa-miR-570-5p94.784NM_033224
PURBhsa-miR-548ai94.784NM_033224
PURBhsa-miR-427794.467NM_033224
PURBhsa-miR-316394.0409NM_033224
PURBhsa-miR-548e-3p93.597NM_033224
PURBhsa-miR-548bc93.597NM_033224
PURBhsa-miR-548f-3p93.597NM_033224
PURBhsa-miR-548a-3p93.597NM_033224
PURBhsa-miR-548az-3p93.597NM_033224
PURBhsa-miR-548ba93.3866NM_033224
PURBhsa-miR-548ag93.3866NM_033224
PURBhsa-miR-3944-5p93.2963NM_033224
PURBhsa-miR-6809-3p93.0231NM_033224
PURBhsa-miR-3613-3p92.825NM_033224
PURBhsa-miR-3619-5p91.1973NM_033224
PURBhsa-miR-214-3p91.172NM_033224
PURBhsa-miR-76191.172NM_033224
PURBhsa-miR-6882-3p91.1433NM_033224
PURBhsa-miR-449a91.0799NM_033224
PURBhsa-miR-34a-5p91.0799NM_033224
PURBhsa-miR-2115-5p90.4496NM_033224
PURBhsa-miR-4677-3p90.1218NM_033224
PURBhsa-miR-584-3p89.5153NM_033224
PURBhsa-miR-446089.2525NM_033224
PURBhsa-miR-373-5p89.043NM_033224
PURBhsa-miR-616-5p89.043NM_033224
PURBhsa-miR-371b-5p89.043NM_033224
PURBhsa-miR-570-3p88.7891NM_033224
PURBhsa-miR-34c-5p88.55NM_033224
PURBhsa-miR-449b-5p88.55NM_033224
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Motifs and transcription factors (TFs) regulating PURB

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
PURBhdpi__NFIXNFIX (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."