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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PTPRZ1

Summary for PTPRZ1

Gene information	Gene symbol	PTPRZ1
	Ensembl ID	ENSG00000106278
	Entrez ID	5803
	Gene name	protein tyrosine phosphatase receptor type Z1
	Synonyms	phosphacan\|PTP18\|PTPRZ\|PTPZ\|RPTPB
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: PTPRZ1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.309748	2.25e-15

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Expression of PTPRZ1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PTPRZ1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PTPRZ1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PTPRZ1	hsa-miR-569	99.4241	NM_001206838
PTPRZ1	hsa-miR-548aj-3p	98.4897	NM_001206838
PTPRZ1	hsa-miR-548x-3p	98.4897	NM_001206838
PTPRZ1	hsa-miR-548d-3p	98.2387	NM_001206838
PTPRZ1	hsa-miR-548bb-3p	97.982	NM_001206838
PTPRZ1	hsa-miR-548z	97.982	NM_001206838
PTPRZ1	hsa-miR-548h-3p	97.982	NM_001206838
PTPRZ1	hsa-miR-548ac	97.982	NM_001206838
PTPRZ1	hsa-miR-548am-3p	97.4139	NM_001206838
PTPRZ1	hsa-miR-548aq-3p	97.4139	NM_001206838
PTPRZ1	hsa-miR-548j-3p	97.4139	NM_001206838
PTPRZ1	hsa-miR-548ah-3p	97.4139	NM_001206838
PTPRZ1	hsa-miR-548ae-3p	97.4139	NM_001206838
PTPRZ1	hsa-miR-133b	95.0438	NM_001206838
PTPRZ1	hsa-miR-133a-3p	95.0438	NM_001206838
PTPRZ1	hsa-miR-302f	94.9499	NM_001206838
PTPRZ1	hsa-miR-3692-3p	94.0267	NM_001206838
PTPRZ1	hsa-miR-429	93.686	NM_001206838
PTPRZ1	hsa-miR-4652-3p	93.543	NM_001206838
PTPRZ1	hsa-miR-1283	93.1725	NM_001206838
PTPRZ1	hsa-miR-200b-3p	92.7854	NM_001206838
PTPRZ1	hsa-miR-200c-3p	92.7854	NM_001206838
PTPRZ1	hsa-miR-548ap-3p	92.7556	NM_001206838
PTPRZ1	hsa-miR-548t-3p	92.7556	NM_001206838
PTPRZ1	hsa-miR-548aa	92.7556	NM_001206838
PTPRZ1	hsa-miR-187-5p	91.3796	NM_001206838
PTPRZ1	hsa-miR-5197-5p	91.3254	NM_001206838
PTPRZ1	hsa-miR-548at-5p	90.951	NM_001206838
PTPRZ1	hsa-miR-3129-5p	89.0313	NM_001206838
PTPRZ1	hsa-miR-199a-3p	89.0313	NM_001206838
PTPRZ1	hsa-miR-199b-3p	89.0313	NM_001206838
PTPRZ1	hsa-miR-4482-3p	88.3723	NM_001206838
PTPRZ1	hsa-miR-4699-3p	86.3367	NM_001206838
PTPRZ1	hsa-miR-5582-5p	85.6227	NM_001206838
PTPRZ1	hsa-miR-548c-3p	84.9955	NM_001206838
PTPRZ1	hsa-miR-6747-3p	84.9564	NM_001206838
PTPRZ1	hsa-miR-506-3p	84.9374	NM_001206838
PTPRZ1	hsa-miR-124-3p	84.9374	NM_001206838
PTPRZ1	hsa-miR-6083	84.4221	NM_001206838
PTPRZ1	hsa-miR-6800-5p	83.8463	NM_001206838
PTPRZ1	hsa-miR-509-5p	81.8078	NM_001206838
PTPRZ1	hsa-miR-509-3-5p	81.8078	NM_001206838
PTPRZ1	hsa-miR-2053	81.6945	NM_001206838
PTPRZ1	hsa-miR-450b-5p	81.4945	NM_001206838
PTPRZ1	hsa-miR-3117-5p	80.8143	NM_001206838

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Motifs and transcription factors (TFs) regulating PTPRZ1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PTPRZ1	metacluster_102.2	ZBED1 (directAnnotation).
PTPRZ1	taipale_tf_pairs__GCM2_ELK1_NNRNGGGCGGAARTN_CAP	ELK1; GCM2 (directAnnotation).
PTPRZ1	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
PTPRZ1	metacluster_141.4	GLIS2 (directAnnotation).
PTPRZ1	transfac_pro__M04950	EGR1 (directAnnotation).
PTPRZ1	metacluster_55.5	ZNF541 (directAnnotation).
PTPRZ1	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).
PTPRZ1	jaspar__MA1117.1	RELB (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."