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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PTPRK

Summary for PTPRK

Gene information	Gene symbol	PTPRK
	Ensembl ID	ENSG00000273993
	Entrez ID	5796
	Gene name	protein tyrosine phosphatase receptor type K
	Synonyms	R-PTP-kappa
	Gene type	protein_coding
	UniProtAcc	Q15262

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Dataset with differentially expressed gene: PTPRK

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.276026	6.07e-17
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.401929	0.00e+00

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Expression of PTPRK in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PTPRK

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PTPRK

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PTPRK	hsa-miR-548aj-3p	99.8816	NM_001135648
PTPRK	hsa-miR-548x-3p	99.8816	NM_001135648
PTPRK	hsa-miR-548j-3p	99.8109	NM_001135648
PTPRK	hsa-miR-548ae-3p	99.8109	NM_001135648
PTPRK	hsa-miR-548am-3p	99.8109	NM_001135648
PTPRK	hsa-miR-548ah-3p	99.8109	NM_001135648
PTPRK	hsa-miR-548aq-3p	99.8109	NM_001135648
PTPRK	hsa-miR-190a-3p	99.416	NM_001135648
PTPRK	hsa-miR-3133	99.264	NM_001135648
PTPRK	hsa-miR-5011-5p	98.8164	NM_001135648
PTPRK	hsa-miR-1912-5p	96.452	NM_001135648
PTPRK	hsa-miR-4801	95.2131	NM_002844
PTPRK	hsa-miR-548z	95.1443	NM_001135648
PTPRK	hsa-miR-548ac	95.1443	NM_001135648
PTPRK	hsa-miR-548h-3p	95.1443	NM_001135648
PTPRK	hsa-miR-548d-3p	95.1443	NM_001135648
PTPRK	hsa-miR-548bb-3p	95.1443	NM_001135648
PTPRK	hsa-miR-498-3p	95.1377	NM_001135648
PTPRK	hsa-miR-133a-3p	94.9327	NM_001135648
PTPRK	hsa-miR-133b	94.9327	NM_001135648
PTPRK	hsa-miR-1283	94.4417	NM_001135648
PTPRK	hsa-miR-545-3p	93.6972	NM_001135648
PTPRK	hsa-miR-4731-3p	93.3075	NM_002844
PTPRK	hsa-miR-4477a	92.3731	NM_001135648
PTPRK	hsa-miR-3613-3p	92.367	NM_001135648
PTPRK	hsa-miR-4282	92.284	NM_002844
PTPRK	hsa-miR-6800-3p	92.0052	NM_002844
PTPRK	hsa-miR-92a-3p	91.2881	NM_001135648
PTPRK	hsa-miR-367-3p	91.2881	NM_001135648
PTPRK	hsa-miR-363-3p	91.2881	NM_001135648
PTPRK	hsa-miR-92b-3p	91.2881	NM_001135648
PTPRK	hsa-miR-32-5p	91.2881	NM_001135648
PTPRK	hsa-miR-12136	91.2054	NM_001135648
PTPRK	hsa-miR-1255b-2-3p	90.0061	NM_001291983
PTPRK	hsa-miR-5589-3p	89.6426	NM_001135648
PTPRK	hsa-miR-6832-5p	88.9668	NM_001291983
PTPRK	hsa-miR-8075	88.8565	NM_002844
PTPRK	hsa-miR-5582-3p	88.7971	NM_001135648
PTPRK	hsa-miR-3145-3p	88.2377	NM_001291983
PTPRK	hsa-miR-5700	87.9131	NM_001291983
PTPRK	hsa-miR-25-3p	87.8249	NM_001135648
PTPRK	hsa-miR-4307	87.3898	NM_001291983
PTPRK	hsa-miR-1183	87.2042	NM_001291983
PTPRK	hsa-miR-5580-5p	86.9935	NM_001135648
PTPRK	hsa-miR-10522-5p	86.5605	NM_001291983
PTPRK	hsa-miR-9-5p	86.075	NM_001135648
PTPRK	hsa-miR-3622b-5p	86.0113	NM_001135648
PTPRK	hsa-miR-4261	85.6692	NM_002844
PTPRK	hsa-miR-1910-5p	85.5086	NM_002844
PTPRK	hsa-miR-95-5p	84.6992	NM_001135648

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Motifs and transcription factors (TFs) regulating PTPRK

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PTPRK	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
PTPRK	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
PTPRK	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
PTPRK	taipale_tf_pairs__ETV2_HES7_NNCACGTGNNNNNCGGAWRY_CAP_repr	ETV2; HES7 (directAnnotation).
PTPRK	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
PTPRK	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
PTPRK	taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_repr	ERF; HES7 (directAnnotation).
PTPRK	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
PTPRK	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
PTPRK	transfac_pro__M00652	NRF1 (directAnnotation).
PTPRK	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
PTPRK	transfac_pro__M04866	HDAC2 (directAnnotation).
PTPRK	jaspar__MA1122.1	TFDP1 (directAnnotation).
PTPRK	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
PTPRK	swissregulon__hs__ELF2	ELF2 (directAnnotation).
PTPRK	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
PTPRK	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
PTPRK	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
PTPRK	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
PTPRK	jaspar__MA0502.2	NFYB (directAnnotation).
PTPRK	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
PTPRK	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
PTPRK	metacluster_7.13	ZFX (directAnnotation).
PTPRK	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
PTPRK	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
PTPRK	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
PTPRK	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
PTPRK	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
PTPRK	cisbp__M00249	WT1 (directAnnotation).
PTPRK	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
PTPRK	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
PTPRK	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
PTPRK	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."