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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: PTPRE

Summary for PTPRE

Gene information	Gene symbol	PTPRE
	Ensembl ID	ENSG00000132334
	Entrez ID	5791
	Gene name	protein tyrosine phosphatase receptor type E
	Synonyms	PTPE
	Gene type	protein_coding
	UniProtAcc	P23469

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Dataset with differentially expressed gene: PTPRE

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.77865	2.55e-06
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	cDCs	-0.300194	3.53e-02
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Mono/Macro	-0.277599	2.73e-07
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	-0.330607	1.64e-04
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.396571	1.50e-15
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	pre	Mono/Macro	0.275909	0.00e+00
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	Mono/Macro	0.415652	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Mono/Macro	-0.30508	5.16e-35
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.561708	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.457322	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-1.01781	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.279298	4.31e-11
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.346584	0.00e+00

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Expression of PTPRE in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PTPRE

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PTPRE

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PTPRE	hsa-miR-524-5p	99.853	NM_001316676
PTPRE	hsa-miR-520d-5p	99.853	NM_001316676
PTPRE	hsa-let-7b-3p	98.0953	NM_001316676
PTPRE	hsa-let-7a-3p	98.0953	NM_001316676
PTPRE	hsa-let-7f-1-3p	98.0953	NM_001316676
PTPRE	hsa-miR-98-3p	98.0953	NM_001316676
PTPRE	hsa-miR-1277-5p	97.3229	NM_001316676
PTPRE	hsa-miR-6852-5p	96.8738	NM_001316676
PTPRE	hsa-miR-3155b	96.5362	NM_001316677
PTPRE	hsa-miR-3155a	96.5362	NM_001316677
PTPRE	hsa-miR-12136	96.4553	NM_001323355
PTPRE	hsa-miR-484	96.1151	NM_001316677
PTPRE	hsa-miR-5688	96.015	NM_001323355
PTPRE	hsa-miR-4711-5p	95.8497	NM_001316677
PTPRE	hsa-miR-495-3p	95.4877	NM_001323355
PTPRE	hsa-miR-6501-3p	95.4659	NM_001316676
PTPRE	hsa-miR-9500	93.5432	NM_001323355
PTPRE	hsa-miR-5094	93.3772	NM_001316676
PTPRE	hsa-miR-340-5p	91.1961	NM_001316677
PTPRE	hsa-miR-6841-3p	91.1233	NM_001316677
PTPRE	hsa-miR-4704-3p	91.004	NM_001316676
PTPRE	hsa-miR-3157-5p	90.7842	NM_001323355
PTPRE	hsa-miR-448	90.6865	NM_001316677
PTPRE	hsa-miR-4297	90.0648	NM_001323355
PTPRE	hsa-miR-5011-5p	89.5475	NM_001316676
PTPRE	hsa-miR-653-3p	89.4937	NM_001316676
PTPRE	hsa-miR-1252-5p	89.439	NM_001316677
PTPRE	hsa-miR-3973	89.3663	NM_001316677
PTPRE	hsa-miR-2115-3p	89.2974	NM_001316676
PTPRE	hsa-miR-4789-5p	88.9919	NM_001316677
PTPRE	hsa-miR-217-3p	88.4395	NM_001316676
PTPRE	hsa-miR-5581-5p	88.1871	NM_001323355
PTPRE	hsa-miR-300	87.918	NM_001323355
PTPRE	hsa-miR-381-3p	87.918	NM_001323355
PTPRE	hsa-miR-208b-5p	87.7945	NM_001323355
PTPRE	hsa-miR-208a-5p	87.7945	NM_001323355
PTPRE	hsa-miR-374b-3p	87.5044	NM_001316676
PTPRE	hsa-miR-383-5p	87.0179	NM_001316676
PTPRE	hsa-miR-6512-5p	86.8235	NM_001323355
PTPRE	hsa-miR-513b-3p	86.4347	NM_001323355
PTPRE	hsa-miR-1207-3p	85.3826	NM_001323355
PTPRE	hsa-miR-34b-3p	84.8293	NM_001316677
PTPRE	hsa-miR-4753-5p	84.0491	NM_001316676
PTPRE	hsa-miR-656-3p	84.0383	NM_001323355
PTPRE	hsa-miR-2681-5p	83.2491	NM_001316676
PTPRE	hsa-miR-570-3p	82.462	NM_001323355
PTPRE	hsa-miR-4666a-3p	80.4413	NM_001323355
PTPRE	hsa-miR-4738-3p	80.3796	NM_001316677
PTPRE	hsa-miR-3680-3p	80.0888	NM_001316677

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Motifs and transcription factors (TFs) regulating PTPRE

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PTPRE	metacluster_7.13	ZFX (directAnnotation).
PTPRE	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
PTPRE	metacluster_151.2	ZNF23 (directAnnotation).
PTPRE	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
PTPRE	hdpi__ETV4	ETV4 (directAnnotation).
PTPRE	transfac_pro__M04617	ZBTB7A (directAnnotation).
PTPRE	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
PTPRE	transfac_pro__M07387	ZBTB7A (directAnnotation).
PTPRE	transfac_pro__M07436	WT1 (directAnnotation).
PTPRE	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
PTPRE	cisbp__M08198	ELF1 (directAnnotation).
PTPRE	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
PTPRE	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
PTPRE	transfac_pro__M04748	GABPA (directAnnotation).
PTPRE	swissregulon__hs__ELF2	ELF2 (directAnnotation).
PTPRE	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
PTPRE	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
PTPRE	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
PTPRE	transfac_pro__M04944	GABPA (directAnnotation).
PTPRE	hdpi__FLI1	FLI1 (directAnnotation).
PTPRE	jaspar__MA1708.1	ETV7 (directAnnotation).
PTPRE	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
PTPRE	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
PTPRE	taipale_tf_pairs__ETV2_HES7_NNCACGTGNNNNNCGGAWRY_CAP_repr	ETV2; HES7 (directAnnotation).
PTPRE	taipale_tf_pairs__FLI1_FOXI1_RCCGGATGTTKWY_CAP	FLI1; FOXI1 (directAnnotation).
PTPRE	c2h2_zfs__M0401	ZNF410 (inferredBy_Orthology).
PTPRE	swissregulon__hs__CUX1	CUX1 (directAnnotation).
PTPRE	transfac_pro__M00962	AR (directAnnotation).
PTPRE	transfac_pro__M04948	HNF4G (directAnnotation).
PTPRE	hocomoco__HAND1_HUMAN.H11MO.1.D	HAND1 (directAnnotation).
PTPRE	metacluster_9.12	LHX4 (directAnnotation).
PTPRE	metacluster_64.14	NR1H4; NR2F1; NR2F1; NR2F1; NR2F1; NR2F6; NR2F6; NR2F6; NR4A2 (directAnnotation). NR1H4; NR1H4 (inferredBy_Orthology).
PTPRE	transfac_pro__M09726	GATAD2A (directAnnotation).
PTPRE	transfac_pro__M06037	ZNF197 (directAnnotation).
PTPRE	tfdimers__MD00527	IRF1; IRF2; IRF3; IRF4; IRF5; IRF6; IRF7; IRF8; ZEB1 (directAnnotation).
PTPRE	taipale_tf_pairs__CLOCK_EVX1_ATRATYANNNNCACGTG_CAP_repr	CLOCK; EVX1 (directAnnotation).
PTPRE	taipale_tf_pairs__HOXA4_RTMATTAN_HT	HOXA4 (directAnnotation).
PTPRE	cisbp__M08190	ZEB1 (directAnnotation).
PTPRE	transfac_pro__M07280	NR1H2; NR1H3; NR1I2; NR1I3; NR2F1; NR2F2; RARA; RARB; RARG; RXRA; RXRB; RXRG (directAnnotation).
PTPRE	tfdimers__MD00474	PAX4; TBP (directAnnotation).
PTPRE	transfac_pro__M05629	ZNF44 (directAnnotation).
PTPRE	metacluster_22.20	MAFG (directAnnotation).
PTPRE	transfac_pro__M09746	HNRNPUL1 (directAnnotation).
PTPRE	hdpi__CHES1	FOXN3 (directAnnotation).
PTPRE	metacluster_22.1	MAFF (inferredBy_Orthology).
PTPRE	metacluster_22.33	MAFK (inferredBy_Orthology).
PTPRE	jaspar__MA1944.1	ETV5 (directAnnotation).
PTPRE	transfac_pro__M12689	ZBTB39 (directAnnotation).
PTPRE	taipale_cyt_meth__POU6F1_NTAATKAGSN_FL_meth	POU6F1 (directAnnotation).
PTPRE	metacluster_22.4	MAFG (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
PTPRE	"Alendronic acid"	DB00630	small molecule
PTPRE	"Tiludronic acid"	DB01133	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."