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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PTHLH

Summary for PTHLH

Gene information	Gene symbol	PTHLH
	Ensembl ID	ENSG00000087494
	Entrez ID	5744
	Gene name	parathyroid hormone like hormone
	Synonyms	HHM\|PLP\|PTHR\|PTHRP
	Gene type	protein_coding
	UniProtAcc	P12272

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Dataset with differentially expressed gene: PTHLH

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.383667	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.609273	0.00e+00

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Expression of PTHLH in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PTHLH

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PTHLH

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PTHLH	hsa-miR-20a-5p	95.2392	NM_198966
PTHLH	hsa-miR-106b-5p	95.2392	NM_198966
PTHLH	hsa-miR-526b-3p	94.9149	NM_198966
PTHLH	hsa-miR-20b-5p	94.9149	NM_198966
PTHLH	hsa-miR-519d-3p	94.9149	NM_198966
PTHLH	hsa-miR-93-5p	94.9149	NM_198966
PTHLH	hsa-miR-17-5p	94.9149	NM_198966
PTHLH	hsa-miR-106a-5p	94.9149	NM_198966
PTHLH	hsa-miR-520d-5p	94.5063	NM_198966
PTHLH	hsa-miR-524-5p	94.5063	NM_198966
PTHLH	hsa-miR-190b-5p	94.1443	NM_198966
PTHLH	hsa-miR-190a-5p	94.1443	NM_198966
PTHLH	hsa-miR-8061	92.8521	NM_198966
PTHLH	hsa-miR-4760-5p	92.8521	NM_198966
PTHLH	hsa-miR-216a-5p	91.0594	NM_002820
PTHLH	hsa-miR-4684-3p	91.042	NM_002820
PTHLH	hsa-miR-592	90.4559	NM_198966
PTHLH	hsa-miR-212-5p	90.192	NM_198966
PTHLH	hsa-miR-143-5p	88.3457	NM_198966
PTHLH	hsa-miR-3935	88.1857	NM_002820
PTHLH	hsa-miR-3714	87.9157	NM_002820
PTHLH	hsa-miR-144-3p	85.5862	NM_198966
PTHLH	hsa-miR-4685-3p	85.0525	NM_002820
PTHLH	hsa-miR-4287	85.0525	NM_002820
PTHLH	hsa-miR-200b-3p	85.0002	NM_198966
PTHLH	hsa-miR-429	85.0002	NM_198966
PTHLH	hsa-miR-200c-3p	85.0002	NM_198966
PTHLH	hsa-miR-500b-5p	84.9512	NM_002820
PTHLH	hsa-miR-362-5p	84.9512	NM_002820
PTHLH	hsa-miR-766-3p	84.6183	NM_002820
PTHLH	hsa-miR-3613-3p	84.1365	NM_198966
PTHLH	hsa-miR-6867-5p	84.0937	NM_002820
PTHLH	hsa-miR-4658	83.7767	NM_002820
PTHLH	hsa-miR-6790-5p	83.7767	NM_002820
PTHLH	hsa-miR-376a-5p	83.4157	NM_198966
PTHLH	hsa-miR-150-3p	83.3741	NM_002820
PTHLH	hsa-miR-7111-5p	82.7598	NM_198966
PTHLH	hsa-miR-6870-5p	82.7598	NM_198966
PTHLH	hsa-miR-4723-5p	82.7598	NM_198966
PTHLH	hsa-miR-5698	82.7598	NM_198966
PTHLH	hsa-miR-1261	82.2044	NM_198966
PTHLH	hsa-miR-519a-3p	80.9192	NM_198966
PTHLH	hsa-miR-519c-3p	80.9192	NM_198966
PTHLH	hsa-miR-519b-3p	80.9192	NM_198966
PTHLH	hsa-miR-4291	80.3374	NM_198966

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Motifs and transcription factors (TFs) regulating PTHLH

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PTHLH	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
PTHLH	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
PTHLH	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
PTHLH	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
PTHLH	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
PTHLH	transfac_pro__M04866	HDAC2 (directAnnotation).
PTHLH	jaspar__MA1122.1	TFDP1 (directAnnotation).
PTHLH	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
PTHLH	metacluster_135.11	NR2C2 (directAnnotation).
PTHLH	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
PTHLH	tfdimers__MD00038	TFAP2C (directAnnotation).
PTHLH	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
PTHLH	metacluster_7.13	ZFX (directAnnotation).
PTHLH	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
PTHLH	cisbp__M00968	MTF2 (directAnnotation).
PTHLH	cisbp__M00341	PAX6 (directAnnotation).
PTHLH	metacluster_198.3	ZFP64 (directAnnotation).
PTHLH	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
PTHLH	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
PTHLH	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
PTHLH	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
PTHLH	cisbp__M00788	ZFY (inferredBy_Orthology).
PTHLH	metacluster_175.1	ZNF283 (directAnnotation).
PTHLH	hdpi__ZNF304	ZNF304 (directAnnotation).
PTHLH	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
PTHLH	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
PTHLH	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
PTHLH	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
PTHLH	metacluster_151.2	ZNF23 (directAnnotation).
PTHLH	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
PTHLH	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
PTHLH	transfac_pro__M03806	ZBTB7C (directAnnotation).
PTHLH	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."