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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: PTGER4

Summary for PTGER4

Gene information	Gene symbol	PTGER4
	Ensembl ID	ENSG00000171522
	Entrez ID	5734
	Gene name	prostaglandin E receptor 4
	Synonyms	EP4
	Gene type	protein_coding
	UniProtAcc	P35408

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Dataset with differentially expressed gene: PTGER4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	CD4+ T cells	-0.250193	5.68e-40
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.38229	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.343873	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.451401	2.95e-14
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	CD8+ T cells	0.32446	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD8+ T cells	0.727588	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	NK cells	0.491362	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD4+ T cells	0.382214	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.266325	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-1.08515	0.00e+00
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	post	NK cells	-0.255447	2.49e-26
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	0.303305	4.61e-02
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD4+ T cells	0.403017	2.38e-12
GSE162117	patients	Peripheral blood mononuclear cells	Acute myeloid leukemia	Tefractory acute myeloid leukemia (AML)	Targeted therapy	ficlatuzumab	post	cDCs	-0.273701	7.74e-10
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.394475	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD8+ T cells	0.473724	3.67e-11
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	NK cells	0.285733	1.48e-02

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Expression of PTGER4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PTGER4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PTGER4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PTGER4	hsa-miR-24-3p	97.1299	NM_000958
PTGER4	hsa-miR-921	97.0948	NM_000958
PTGER4	hsa-miR-23c	96.6703	NM_000958
PTGER4	hsa-miR-23b-3p	96.6703	NM_000958
PTGER4	hsa-miR-23a-3p	96.6703	NM_000958
PTGER4	hsa-miR-4282	96.0049	NM_000958
PTGER4	hsa-miR-484	95.0881	NM_000958
PTGER4	hsa-miR-3155b	94.1094	NM_000958
PTGER4	hsa-miR-3155a	94.1094	NM_000958
PTGER4	hsa-miR-4307	93.5804	NM_000958
PTGER4	hsa-miR-1290	91.8072	NM_000958
PTGER4	hsa-miR-320a-5p	91.5832	NM_000958
PTGER4	hsa-miR-92a-3p	91.5041	NM_000958
PTGER4	hsa-miR-92b-3p	91.5041	NM_000958
PTGER4	hsa-miR-32-5p	91.5041	NM_000958
PTGER4	hsa-miR-3919	90.979	NM_000958
PTGER4	hsa-miR-519d-5p	89.8121	NM_000958
PTGER4	hsa-miR-342-3p	89.1885	NM_000958
PTGER4	hsa-miR-6083	88.9409	NM_000958
PTGER4	hsa-miR-367-3p	88.5	NM_000958
PTGER4	hsa-miR-363-3p	88.5	NM_000958
PTGER4	hsa-miR-25-3p	88.5	NM_000958
PTGER4	hsa-miR-2117	88.2423	NM_000958
PTGER4	hsa-miR-1305	87.9011	NM_000958
PTGER4	hsa-miR-1253	87.1985	NM_000958
PTGER4	hsa-miR-3144-3p	86.6224	NM_000958
PTGER4	hsa-miR-1207-3p	86.1164	NM_000958
PTGER4	hsa-miR-3200-3p	86.0372	NM_000958
PTGER4	hsa-miR-6813-3p	86.0372	NM_000958
PTGER4	hsa-miR-6809-3p	85.4391	NM_000958
PTGER4	hsa-miR-4303	85.0961	NM_000958
PTGER4	hsa-miR-138-2-3p	85.087	NM_000958
PTGER4	hsa-miR-4782-5p	84.1942	NM_000958
PTGER4	hsa-miR-5706	84.1942	NM_000958
PTGER4	hsa-miR-590-3p	84.0856	NM_000958
PTGER4	hsa-miR-624-5p	82.919	NM_000958
PTGER4	hsa-miR-3613-3p	81.9251	NM_000958
PTGER4	hsa-miR-1227-3p	80.5799	NM_000958
PTGER4	hsa-miR-487b-5p	80.1436	NM_000958
PTGER4	hsa-miR-487a-5p	80.1436	NM_000958

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Motifs and transcription factors (TFs) regulating PTGER4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PTGER4	cisbp__M00341	PAX6 (directAnnotation).
PTGER4	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
PTGER4	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
PTGER4	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
PTGER4	taipale_tf_pairs__ERF_PITX1_NSCGGANNNNNNGGMTTA_CAP	ERF; PITX1 (directAnnotation).
PTGER4	jaspar__MA1956.1	FOXO1 (directAnnotation).
PTGER4	jaspar__MA1954.1	FOXO1 (directAnnotation).
PTGER4	transfac_pro__M04966	EP300 (directAnnotation).
PTGER4	transfac_pro__M01251	E2F1 (directAnnotation).
PTGER4	jaspar__MA1953.1	FOXO1 (directAnnotation).
PTGER4	taipale_tf_pairs__ELK1_EVX1_RSCGGWANNNNYMATTA_CAP_repr	ELK1; EVX1 (directAnnotation).
PTGER4	metacluster_172.27	DMRTC2 (directAnnotation).
PTGER4	taipale_tf_pairs__FLI1_DLX2_RSCGGAARYAATTA_CAP	DLX2; FLI1 (directAnnotation).
PTGER4	metacluster_20.5	DLX1; DLX4; DLX4 (directAnnotation).
PTGER4	metacluster_157.2	ATF3; ATF3; ATF3; BACH1; BACH1; BACH1; BACH2; BACH2; BACH2; BACH2; BATF; BATF; BCL11A; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; MAF; MAFB; MAFF; MAFG; MAFK; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2; NFE2L3; ZNF3; ZSCAN5C (directAnnotation). FOSL1; JUN; JUN; JUN; JUNB; JUNB; JUND (inferredBy_Orthology).
PTGER4	cisbp__M00282	PHOX2B (directAnnotation).
PTGER4	transfac_pro__M06832	PEG3 (directAnnotation).
PTGER4	transfac_pro__M04826	EP300 (directAnnotation).
PTGER4	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
PTGER4	swissregulon__hs__ELF2	ELF2 (directAnnotation).
PTGER4	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
PTGER4	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
PTGER4	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
PTGER4	hdpi__TP73	TP73 (directAnnotation).
PTGER4	cisbp__M08198	ELF1 (directAnnotation).
PTGER4	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
PTGER4	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
PTGER4	transfac_pro__M04950	EGR1 (directAnnotation).
PTGER4	transfac_pro__M06032	ZNF727 (directAnnotation).
PTGER4	taipale_tf_pairs__ETV2_FOXI1_RNCGGAANNAAACA_CAP_repr	ETV2; FOXI1 (directAnnotation).
PTGER4	taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP	ETV1; HOXB2 (directAnnotation).
PTGER4	transfac_pro__M05706	ZNF20 (directAnnotation).
PTGER4	swissregulon__hs__GMEB2	GMEB2 (directAnnotation).
PTGER4	jaspar__MA1933.1	SREBF2 (directAnnotation).
PTGER4	transfac_pro__M06688	ZKSCAN7 (directAnnotation).
PTGER4	transfac_pro__M06249	ZNF616 (directAnnotation).
PTGER4	tfdimers__MD00595	SREBF1; SREBF2; TBP (directAnnotation).
PTGER4	swissregulon__hs__FOXO3	FOXO3 (directAnnotation).
PTGER4	metacluster_7.7	SP2 (directAnnotation). KLF16 (inferredBy_Orthology).
PTGER4	metacluster_46.4	CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; DBP; DBP; EP300; GATAD2A; HES2 (directAnnotation). CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPE; CEBPE; CEBPE; CEBPG; CEBPG; HLF; HLF (inferredBy_Orthology).
PTGER4	metacluster_172.6	CHD2; E2F1 (directAnnotation).
PTGER4	metacluster_167.7	IRF8 (inferredBy_Orthology).
PTGER4	homer__ATTGCGCAAC_CEBP	CEBPB (inferredBy_Orthology).
PTGER4	metacluster_46.5	HLF; TEF (directAnnotation).
PTGER4	transfac_pro__M04886	ETS1 (directAnnotation).
PTGER4	metacluster_22.18	BACH2 (inferredBy_Orthology).
PTGER4	metacluster_22.36	BACH2 (directAnnotation).
PTGER4	metacluster_22.37	BACH1 (directAnnotation).
PTGER4	transfac_pro__M06826	ZNF516 (inferredBy_Orthology).
PTGER4	metacluster_2.6	IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF2; IRF2; IRF2; IRF2; IRF2; IRF2; IRF2; IRF3; IRF3; IRF3; IRF3; IRF3; IRF3; IRF4; IRF4; IRF4; IRF4; IRF4; IRF5; IRF5; IRF5; IRF5; IRF5; IRF5; IRF5; IRF6; IRF7; IRF7; IRF7; IRF7; IRF7; IRF7; IRF7; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF9; IRF9; IRF9; IRF9; IRF9; IRF9; IRF9; STAT1; STAT2; STAT2; STAT2; STAT2; ZNF426; ZNF71 (directAnnotation). IRF1; IRF1; IRF3; IRF8 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
PTGER4	"Castor oil"	DB11113	biotech
PTGER4	"Dinoprostone"	DB00917	small molecule
PTGER4	"Grapiprant"	DB12836	small molecule
PTGER4	"Limaprost"	DB09211	small molecule
PTGER4	"Misoprostol"	DB00929	small molecule
PTGER4	"Rivenprost"	DB16315	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."