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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PTBP2

Summary for PTBP2

Gene information	Gene symbol	PTBP2
	Ensembl ID	ENSG00000117569
	Entrez ID	58155
	Gene name	polypyrimidine tract binding protein 2
	Synonyms	brPTB\|nPTB\|PTB\|PTBLP
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: PTBP2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.270746	0.00e+00

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Expression of PTBP2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PTBP2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PTBP2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PTBP2	hsa-miR-3148	99.3883	NM_001300985
PTBP2	hsa-miR-548aj-3p	99.2882	NM_001300985
PTBP2	hsa-miR-548x-3p	99.2882	NM_001300985
PTBP2	hsa-miR-548j-3p	99.0597	NM_001300985
PTBP2	hsa-miR-548am-3p	99.0597	NM_001300985
PTBP2	hsa-miR-548ae-3p	99.0597	NM_001300985
PTBP2	hsa-miR-548aq-3p	99.0597	NM_001300985
PTBP2	hsa-miR-548ah-3p	99.0597	NM_001300985
PTBP2	hsa-miR-4775	99.0585	NM_001300986
PTBP2	hsa-miR-548v	98.9578	NM_001300985
PTBP2	hsa-miR-329-3p	98.704	NM_001300985
PTBP2	hsa-miR-362-3p	98.704	NM_001300985
PTBP2	hsa-miR-3941	98.0055	NM_001300985
PTBP2	hsa-miR-8485	97.8931	NM_001300985
PTBP2	hsa-miR-548ar-3p	97.1972	NM_001300985
PTBP2	hsa-miR-548a-3p	97.1492	NM_001300985
PTBP2	hsa-miR-548f-3p	97.1492	NM_001300985
PTBP2	hsa-miR-548bc	97.1492	NM_001300985
PTBP2	hsa-miR-590-3p	96.9404	NM_001300986
PTBP2	hsa-miR-506-3p	96.9177	NM_001300985
PTBP2	hsa-miR-124-3p	96.9177	NM_001300985
PTBP2	hsa-miR-548az-3p	96.6549	NM_001300985
PTBP2	hsa-miR-548e-3p	96.6549	NM_001300985
PTBP2	hsa-miR-6768-3p	96.5141	NM_001300985
PTBP2	hsa-miR-499a-5p	95.9922	NM_001300985
PTBP2	hsa-miR-603	95.9657	NM_001300985
PTBP2	hsa-miR-223-3p	95.4606	NM_001300986
PTBP2	hsa-miR-505-3p	94.7388	NM_001300985
PTBP2	hsa-miR-212-3p	94.6237	NM_001300985
PTBP2	hsa-miR-132-3p	94.6237	NM_001300985
PTBP2	hsa-miR-1260b	94.1515	NM_001300985
PTBP2	hsa-miR-1260a	94.1515	NM_001300985
PTBP2	hsa-miR-3622a-5p	94.0225	NM_001300985
PTBP2	hsa-miR-3121-3p	93.3855	NM_001300986
PTBP2	hsa-miR-4729	93.347	NM_001300985
PTBP2	hsa-miR-4722-5p	93.2363	NM_001300985
PTBP2	hsa-miR-607	93.0998	NM_001300986
PTBP2	hsa-miR-4691-3p	92.6697	NM_001300985
PTBP2	hsa-miR-4773	92.271	NM_001300986
PTBP2	hsa-miR-3157-5p	92.1139	NM_001300985
PTBP2	hsa-miR-548ac	91.4226	NM_001300985
PTBP2	hsa-miR-548bb-3p	91.4226	NM_001300985
PTBP2	hsa-miR-548h-3p	91.4226	NM_001300985
PTBP2	hsa-miR-548d-3p	91.4226	NM_001300985
PTBP2	hsa-miR-548z	91.4226	NM_001300985
PTBP2	hsa-miR-1224-3p	90.9736	NM_001300985
PTBP2	hsa-miR-4286	90.8726	NM_001300985
PTBP2	hsa-miR-6124	90.7105	NM_001300985
PTBP2	hsa-miR-3692-3p	90.6216	NM_001300986
PTBP2	hsa-miR-5009-3p	90.5933	NM_001300986

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Motifs and transcription factors (TFs) regulating PTBP2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PTBP2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
PTBP2	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
PTBP2	jaspar__MA1721.1	ZNF93 (directAnnotation).
PTBP2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
PTBP2	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
PTBP2	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
PTBP2	transfac_pro__M01199	TRIM28 (directAnnotation).
PTBP2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
PTBP2	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
PTBP2	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
PTBP2	transfac_pro__M02913	SP140 (inferredBy_Orthology).
PTBP2	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
PTBP2	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
PTBP2	jaspar__MA0748.2	YY2 (directAnnotation).
PTBP2	swissregulon__hs__CHD1	CHD1 (directAnnotation).
PTBP2	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
PTBP2	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
PTBP2	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
PTBP2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
PTBP2	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
PTBP2	transfac_pro__M00938	E2F1 (directAnnotation).
PTBP2	transfac_pro__M04893	TAF1 (directAnnotation).
PTBP2	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
PTBP2	transfac_pro__M12697	ZNF142 (directAnnotation).
PTBP2	metacluster_175.1	ZNF283 (directAnnotation).
PTBP2	cisbp__M00788	ZFY (inferredBy_Orthology).
PTBP2	tfdimers__MD00364	WT1 (directAnnotation).
PTBP2	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
PTBP2	transfac_pro__M02786	PLAGL1 (inferredBy_Orthology).
PTBP2	transfac_pro__M01973	PLAG1 (directAnnotation).
PTBP2	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
PTBP2	tfdimers__MD00483	ZBTB14 (directAnnotation).
PTBP2	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
PTBP2	hocomoco__XBP1_HUMAN.H11MO.0.D	XBP1 (directAnnotation).
PTBP2	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
PTBP2	metacluster_144.13	HIC1; HIC1 (directAnnotation).
PTBP2	transfac_pro__M00514	ATF4 (directAnnotation).
PTBP2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
PTBP2	transfac_pro__M02898	SMAD3 (directAnnotation).
PTBP2	kznf__ZNF548_Imbeault2017_OM_RCADE	ZNF548 (directAnnotation).
PTBP2	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
PTBP2	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
PTBP2	metacluster_196.3	NR1H4; NR2F6; PRDM14; ZNF264; ZNF264 (directAnnotation). HNF4A; HNF4G; NR1D1; NR1D1; NR1D1; NR1D2; NR1D2; NR1D2; NR1H2; NR1H2; NR1H2; NR1H3; NR1H3; NR1H3; NR1I2; NR1I2; NR1I2; NR2C1; NR2C2; NR2F2; NR2F6; PPARA; PPARA; PPARA; PPARD; PPARD; PPARD; PPARG; PPARG; PPARG; RARA; RARA; RARA; RARB; RARB; RARB; RORA; RORA; RORA; RORB; RORB; RORB; RORC; RORC; RORC; RXRA; RXRB; RXRG; THRA; THRA; THRA; VDR; VDR; VDR (inferredBy_Orthology).
PTBP2	hocomoco__ZFP57_MOUSE.H11MO.0.B	ZFP57 (inferredBy_Orthology).
PTBP2	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
PTBP2	taipale_tf_pairs__ETV5_TCF3_RNCGGAAGNNNNNCASSTGN_CAP_repr	ETV5; TCF3 (directAnnotation).
PTBP2	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
PTBP2	metacluster_126.4	ZNF12; ZNF12; ZNF44; ZNF563; ZNF93 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."