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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PTBP1

Summary for PTBP1

Gene information	Gene symbol	PTBP1
	Ensembl ID	ENSG00000011304
	Entrez ID	5725
	Gene name	polypyrimidine tract binding protein 1
	Synonyms	HNRNP-I\|HNRPI\|pPTB\|PTB\|PTB-1\|PTB2\|PTB3\|PTB4
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: PTBP1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.363191	0.00e+00
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	0.316686	1.52e-13
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.41296	1.53e-24
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.422654	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.374746	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.382221	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.271837	9.32e-16

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Expression of PTBP1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PTBP1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PTBP1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PTBP1	hsa-miR-133b	99.2654	NM_002819
PTBP1	hsa-miR-133a-3p	99.2654	NM_002819
PTBP1	hsa-miR-518c-5p	98.5323	NM_002819
PTBP1	hsa-miR-3191-5p	98.1357	NM_002819
PTBP1	hsa-miR-124-3p	98.0379	NM_002819
PTBP1	hsa-miR-6824-3p	97.9689	NM_002819
PTBP1	hsa-miR-6764-3p	97.9689	NM_002819
PTBP1	hsa-miR-506-3p	97.643	NM_002819
PTBP1	hsa-miR-3163	96.884	NM_002819
PTBP1	hsa-miR-448	96.5621	NM_002819
PTBP1	hsa-miR-5582-5p	95.0177	NM_002819
PTBP1	hsa-miR-153-3p	94.4681	NM_002819
PTBP1	hsa-miR-6809-3p	94.3199	NM_031990
PTBP1	hsa-miR-330-5p	93.1957	NM_002819
PTBP1	hsa-miR-3680-3p	92.856	NM_002819
PTBP1	hsa-miR-6128	92.3924	NM_002819
PTBP1	hsa-miR-4753-3p	92.3825	NM_031990
PTBP1	hsa-miR-624-3p	92.2885	NM_002819
PTBP1	hsa-miR-3910	91.946	NM_002819
PTBP1	hsa-miR-5002-5p	91.8182	NM_002819
PTBP1	hsa-miR-3714	91.7383	NM_002819
PTBP1	hsa-miR-4775	91.0731	NM_031990
PTBP1	hsa-miR-6830-5p	90.632	NM_002819
PTBP1	hsa-miR-326	89.6901	NM_002819
PTBP1	hsa-miR-6811-3p	88.3218	NM_002819
PTBP1	hsa-miR-10394-5p	87.3257	NM_031990
PTBP1	hsa-miR-1205	87.3257	NM_031990
PTBP1	hsa-miR-507	86.3236	NM_002819
PTBP1	hsa-miR-450b-5p	86.3236	NM_002819
PTBP1	hsa-miR-557	86.2747	NM_002819
PTBP1	hsa-miR-1468-3p	85.5843	NM_002819
PTBP1	hsa-miR-1299	85.1193	NM_002819
PTBP1	hsa-miR-369-3p	84.3636	NM_031990
PTBP1	hsa-miR-130b-5p	83.0784	NM_002819
PTBP1	hsa-miR-130a-5p	83.0784	NM_002819
PTBP1	hsa-miR-1207-3p	82.6189	NM_002819
PTBP1	hsa-miR-3646	81.6412	NM_031990
PTBP1	hsa-miR-875-3p	80.5955	NM_002819

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Motifs and transcription factors (TFs) regulating PTBP1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PTBP1	metacluster_7.13	ZFX (directAnnotation).
PTBP1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
PTBP1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
PTBP1	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
PTBP1	metacluster_182.10	ZFX (directAnnotation).
PTBP1	transfac_pro__M06071	ZNF814 (directAnnotation).
PTBP1	transfac_pro__M05628	ZNF735 (directAnnotation).
PTBP1	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
PTBP1	tfdimers__MD00151	CHURC1 (directAnnotation).
PTBP1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
PTBP1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
PTBP1	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
PTBP1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
PTBP1	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
PTBP1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
PTBP1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
PTBP1	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
PTBP1	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
PTBP1	taipale_tf_pairs__ETV2_HES7_NNCACGTGNNNNNCGGAWRY_CAP_repr	ETV2; HES7 (directAnnotation).
PTBP1	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
PTBP1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
PTBP1	cisbp__M08198	ELF1 (directAnnotation).
PTBP1	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
PTBP1	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
PTBP1	taipale_tf_pairs__TEAD4_ETV4_RCCGGAAATRCC_CAP	ETV4; TEAD4 (directAnnotation).
PTBP1	hdpi__FLI1	FLI1 (directAnnotation).
PTBP1	metacluster_55.5	ZNF541 (directAnnotation).
PTBP1	cisbp__M00341	PAX6 (directAnnotation).
PTBP1	cisbp__M00788	ZFY (inferredBy_Orthology).
PTBP1	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
PTBP1	metacluster_141.2	E2F2; E2F3 (directAnnotation).
PTBP1	metacluster_141.4	GLIS2 (directAnnotation).
PTBP1	jaspar__MA0748.2	YY2 (directAnnotation).
PTBP1	metacluster_45.6	E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F4; E2F4 (directAnnotation). E2F2; E2F3 (inferredBy_Orthology).
PTBP1	jaspar__MA1460.1	YY1 (inferredBy_Orthology).
PTBP1	taipale__YY2_DBD_NNCCGCCATNW_repr	YY2 (directAnnotation).
PTBP1	kznf__ZNF343_Imbeault2017_OM_RCADE	ZNF343 (directAnnotation).
PTBP1	transfac_pro__M02913	SP140 (inferredBy_Orthology).
PTBP1	transfac_pro__M07483	CXXC1 (directAnnotation).
PTBP1	jaspar__MA1483.2	ELF2 (directAnnotation).
PTBP1	swissregulon__hs__ELF2	ELF2 (directAnnotation).
PTBP1	taipale_tf_pairs__HOXD12_ELK3_NTTTAYNNCCGGAARNN_CAP_repr	ELK3; HOXD12 (directAnnotation).
PTBP1	transfac_public__M00024	E2F1 (directAnnotation).
PTBP1	hocomoco__KAISO_HUMAN.H11MO.2.A	ZBTB33 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."