Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: PTAFR

Summary for PTAFR

Gene information	Gene symbol	PTAFR
	Ensembl ID	ENSG00000169403
	Entrez ID	5724
	Gene name	platelet activating factor receptor
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	P25105

Top

Dataset with differentially expressed gene: PTAFR

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-1.01327	2.67e-03
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.339864	2.13e-07
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	Mono/Macro	0.305949	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	-0.307916	1.88e-04

Top

Expression of PTAFR in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to PTAFR

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating PTAFR

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PTAFR	hsa-miR-4500	99.0498	NM_000952
PTAFR	hsa-let-7a-5p	98.525	NM_000952
PTAFR	hsa-let-7c-5p	98.525	NM_000952
PTAFR	hsa-let-7f-5p	98.525	NM_000952
PTAFR	hsa-let-7i-5p	98.525	NM_000952
PTAFR	hsa-let-7e-5p	98.525	NM_000952
PTAFR	hsa-let-7b-5p	98.525	NM_000952
PTAFR	hsa-miR-98-5p	98.525	NM_000952
PTAFR	hsa-let-7g-5p	98.525	NM_000952
PTAFR	hsa-miR-4458	97.9881	NM_000952
PTAFR	hsa-let-7d-5p	97.9881	NM_000952
PTAFR	hsa-miR-6752-3p	92.6957	NM_001164721
PTAFR	hsa-miR-12122	91.8983	NM_000952
PTAFR	hsa-miR-3149	90.8526	NM_001164721
PTAFR	hsa-miR-545-3p	90.4193	NM_001164721
PTAFR	hsa-miR-567	88.2937	NM_001164721
PTAFR	hsa-miR-4477a	87.9702	NM_001164721
PTAFR	hsa-miR-619-5p	87.8674	NM_001164721
PTAFR	hsa-miR-6778-3p	86.5602	NM_001164721
PTAFR	hsa-miR-4291	85.9798	NM_001164721
PTAFR	hsa-miR-765	85.0583	NM_001164721
PTAFR	hsa-miR-4704-3p	84.1587	NM_001164721
PTAFR	hsa-miR-4755-3p	83.9704	NM_001164721
PTAFR	hsa-miR-1913	82.7483	NM_001164721
PTAFR	hsa-miR-5006-5p	82.4427	NM_001164721
PTAFR	hsa-miR-8065	81.8353	NM_000952
PTAFR	hsa-miR-6506-5p	81.6062	NM_001164721
PTAFR	hsa-miR-7151-3p	80.7085	NM_001164721
PTAFR	hsa-miR-12124	80.5388	NM_000952

Page: 1

Top

Motifs and transcription factors (TFs) regulating PTAFR

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PTAFR	jaspar__MA1509.1	IRF6 (directAnnotation).
PTAFR	taipale_tf_pairs__ELK1_SPDEF_NSMGGACGGAYNTCCKSN_CAP	ELK1; SPDEF (directAnnotation).
PTAFR	tfdimers__MD00034	PDX1; SOX2 (directAnnotation).
PTAFR	transfac_pro__M06313	ZNF678 (directAnnotation).
PTAFR	tfdimers__MD00476	BACH1; BACH2; FOXG1; FOXO1; MAF; MAFB; MAFF; MAFG; MAFK; NFE2; NFE2L1; NFE2L2; NFE2L3 (directAnnotation).
PTAFR	taipale_tf_pairs__ETV2_SPDEF_NSCGGACGGAWATCCGSNT_CAP	ETV2; SPDEF (directAnnotation).
PTAFR	metacluster_27.20	ZNF708; ZNF787; ZNF787; ZNF85 (directAnnotation).
PTAFR	taipale_tf_pairs__RFX3_SREBF2_NNRGYAACNTCACGTGAY_CAP_repr	RFX3; SREBF2 (directAnnotation).
PTAFR	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
PTAFR	transfac_pro__M05613	ZNF35 (directAnnotation).
PTAFR	metacluster_12.1	ZNF3 (directAnnotation).
PTAFR	kznf__ZNF785_Imbeault2017_OM_MEME	ZNF785 (directAnnotation).
PTAFR	transfac_pro__M06398	ZNF761 (directAnnotation).
PTAFR	transfac_pro__M06263	ZNF211 (directAnnotation).
PTAFR	transfac_pro__M06013	ZFP69B (directAnnotation).
PTAFR	tfdimers__MD00433	NKX3-2; ZNF217 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
PTAFR	"Etizolam"	DB09166	small molecule
PTAFR	"Platelet Activating Factor"	DB02261	small molecule
PTAFR	"Rupatadine"	DB11614	small molecule

Page: 1

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."