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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PSMF1

Summary for PSMF1

Gene information	Gene symbol	PSMF1
	Ensembl ID	ENSG00000125818
	Entrez ID	9491
	Gene name	proteasome inhibitor subunit 1
	Synonyms	PI31
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: PSMF1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.376282	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.306219	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	0.390716	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.276635	2.40e-15
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.251999	1.42e-09
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.350664	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	-0.324472	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.490278	2.10e-29
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.363363	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.267724	0.00e+00

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Expression of PSMF1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PSMF1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PSMF1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PSMF1	hsa-miR-6852-5p	97.0173	NM_001323408
PSMF1	hsa-miR-659-3p	96.3831	NM_006814
PSMF1	hsa-miR-760	92.3801	NM_006814
PSMF1	hsa-miR-4495	92.3187	NM_006814
PSMF1	hsa-miR-2116-5p	91.4241	NM_001323409
PSMF1	hsa-miR-26b-3p	90.844	NM_001323409
PSMF1	hsa-miR-665	90.0275	NM_006814
PSMF1	hsa-miR-4447	87.9249	NM_001323408
PSMF1	hsa-miR-12125	87.8821	NM_001323408
PSMF1	hsa-miR-4660	87.3629	NM_001323409
PSMF1	hsa-miR-1184	86.6456	NM_006814
PSMF1	hsa-miR-6770-5p	84.8872	NM_001323409
PSMF1	hsa-miR-4666a-5p	84.4614	NM_001323409
PSMF1	hsa-miR-8075	84.3556	NM_001323409
PSMF1	hsa-miR-9902	84.264	NM_001323410
PSMF1	hsa-miR-3189-3p	84.2524	NM_001323409
PSMF1	hsa-miR-584-5p	83.5279	NM_001323408
PSMF1	hsa-miR-6721-5p	82.924	NM_006814
PSMF1	hsa-miR-6804-3p	82.4377	NM_001323408
PSMF1	hsa-miR-4700-5p	81.9209	NM_001323408
PSMF1	hsa-miR-4742-3p	81.8859	NM_006814
PSMF1	hsa-miR-939-3p	81.7598	NM_006814
PSMF1	hsa-miR-758-5p	81.6691	NM_001323408
PSMF1	hsa-miR-1913	81.3785	NM_006814
PSMF1	hsa-miR-4725-3p	81.3676	NM_001323408
PSMF1	hsa-miR-6780b-5p	81.3676	NM_001323408
PSMF1	hsa-miR-3688-5p	81.1926	NM_006814
PSMF1	hsa-miR-5698	80.9759	NM_001323409
PSMF1	hsa-miR-4723-5p	80.9759	NM_001323409
PSMF1	hsa-miR-6870-5p	80.9759	NM_001323409
PSMF1	hsa-miR-7111-5p	80.9759	NM_001323409
PSMF1	hsa-miR-586	80.9268	NM_006814
PSMF1	hsa-miR-1253	80.7897	NM_001323409
PSMF1	hsa-miR-653-3p	80.7317	NM_001323408
PSMF1	hsa-miR-6742-3p	80.684	NM_001323408
PSMF1	hsa-miR-4643	80.5698	NM_001323409
PSMF1	hsa-miR-5047	80.2391	NM_006814
PSMF1	hsa-miR-1301-3p	80.2391	NM_006814

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Motifs and transcription factors (TFs) regulating PSMF1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PSMF1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
PSMF1	jaspar__MA1483.2	ELF2 (directAnnotation).
PSMF1	hdpi__ETV4	ETV4 (directAnnotation).
PSMF1	hdpi__FLI1	FLI1 (directAnnotation).
PSMF1	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
PSMF1	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
PSMF1	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
PSMF1	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
PSMF1	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
PSMF1	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
PSMF1	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
PSMF1	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
PSMF1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
PSMF1	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
PSMF1	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
PSMF1	swissregulon__hs__ELF2	ELF2 (directAnnotation).
PSMF1	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
PSMF1	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
PSMF1	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
PSMF1	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
PSMF1	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
PSMF1	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
PSMF1	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
PSMF1	jaspar__MA1957.1	ELK1 (directAnnotation).
PSMF1	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
PSMF1	metacluster_134.4	AHDC1; ARID5B; FOXA1; FOXA1; FOXA2; FOXA2; FOXA3; FOXA3; FOXJ3; FOXO3; FOXP1; FOXP4 (directAnnotation).
PSMF1	homer__ATTGCGCAAC_CEBP	CEBPB (inferredBy_Orthology).
PSMF1	transfac_pro__M01968	FOXO1 (directAnnotation).
PSMF1	transfac_pro__M04826	EP300 (directAnnotation).
PSMF1	hdpi__ELF2	ELF2 (directAnnotation).
PSMF1	swissregulon__hs__ELK1	ELK1 (directAnnotation).
PSMF1	transfac_pro__M00492	STAT1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."