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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PSME4

Summary for PSME4

Gene information	Gene symbol	PSME4
	Ensembl ID	ENSG00000068878
	Entrez ID	23198
	Gene name	proteasome activator subunit 4
	Synonyms	KIAA0077\|PA200
	Gene type	protein_coding
	UniProtAcc	Q14997

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Dataset with differentially expressed gene: PSME4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.274406	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.453013	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.572425	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.502768	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.264309	8.11e-11

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Expression of PSME4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PSME4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PSME4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PSME4	hsa-miR-186-5p	96.7691	NM_014614
PSME4	hsa-miR-4770	96.043	NM_014614
PSME4	hsa-miR-143-3p	96.043	NM_014614
PSME4	hsa-miR-410-3p	95.9819	NM_014614
PSME4	hsa-miR-3613-3p	95.6502	NM_014614
PSME4	hsa-miR-4329	95.2428	NM_014614
PSME4	hsa-miR-6088	95.2427	NM_014614
PSME4	hsa-miR-5197-5p	94.1082	NM_014614
PSME4	hsa-miR-11399	93.9256	NM_014614
PSME4	hsa-miR-4291	93.0223	NM_014614
PSME4	hsa-miR-3065-3p	91.5869	NM_014614
PSME4	hsa-miR-4708-5p	88.8909	NM_014614
PSME4	hsa-miR-4251	87.8729	NM_014614
PSME4	hsa-miR-4742-5p	87.7666	NM_014614
PSME4	hsa-miR-136-5p	86.8666	NM_014614
PSME4	hsa-miR-4698	86.7925	NM_014614
PSME4	hsa-miR-6811-5p	86.6829	NM_014614
PSME4	hsa-miR-1468-3p	86.3372	NM_014614
PSME4	hsa-miR-6776-3p	86.1792	NM_014614
PSME4	hsa-miR-5008-3p	85.5043	NM_014614
PSME4	hsa-miR-7157-3p	85.5043	NM_014614
PSME4	hsa-miR-6737-3p	85.5043	NM_014614
PSME4	hsa-miR-3133	85.3746	NM_014614
PSME4	hsa-miR-4477b	85.3009	NM_014614
PSME4	hsa-miR-203b-3p	85.2517	NM_014614
PSME4	hsa-miR-4328	84.464	NM_014614
PSME4	hsa-miR-1185-2-3p	84.346	NM_014614
PSME4	hsa-miR-1185-1-3p	84.346	NM_014614
PSME4	hsa-let-7f-2-3p	84.346	NM_014614
PSME4	hsa-miR-4789-5p	84.1504	NM_014614
PSME4	hsa-miR-3941	84.1294	NM_014614
PSME4	hsa-miR-34b-3p	83.908	NM_014614
PSME4	hsa-miR-96-5p	83.2922	NM_014614
PSME4	hsa-miR-377-3p	82.8753	NM_014614
PSME4	hsa-miR-6504-3p	82.4765	NM_014614
PSME4	hsa-miR-10399-5p	82.4765	NM_014614
PSME4	hsa-miR-10394-5p	82.14	NM_014614
PSME4	hsa-miR-1205	82.14	NM_014614
PSME4	hsa-miR-139-5p	81.9312	NM_014614
PSME4	hsa-miR-4470	81.0816	NM_014614
PSME4	hsa-miR-5692a	81.022	NM_014614
PSME4	hsa-miR-6794-3p	80.8144	NM_014614
PSME4	hsa-miR-7114-5p	80.5376	NM_014614
PSME4	hsa-miR-197-3p	80.0541	NM_014614

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Motifs and transcription factors (TFs) regulating PSME4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PSME4	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
PSME4	transfac_pro__M01238	DEAF1 (inferredBy_Orthology).
PSME4	taipale_tf_pairs__TFAP2C_DLX3_NSCCNNNRGGCANNNNNNTAATKR_CAP_repr	DLX3; TFAP2C (directAnnotation).
PSME4	transfac_pro__M02898	SMAD3 (directAnnotation).
PSME4	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
PSME4	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
PSME4	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
PSME4	transfac_pro__M02786	PLAGL1 (inferredBy_Orthology).
PSME4	metacluster_198.3	ZFP64 (directAnnotation).
PSME4	metacluster_143.13	ZBTB7A (directAnnotation).
PSME4	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
PSME4	metacluster_196.3	NR1H4; NR2F6; PRDM14; ZNF264; ZNF264 (directAnnotation). HNF4A; HNF4G; NR1D1; NR1D1; NR1D1; NR1D2; NR1D2; NR1D2; NR1H2; NR1H2; NR1H2; NR1H3; NR1H3; NR1H3; NR1I2; NR1I2; NR1I2; NR2C1; NR2C2; NR2F2; NR2F6; PPARA; PPARA; PPARA; PPARD; PPARD; PPARD; PPARG; PPARG; PPARG; RARA; RARA; RARA; RARB; RARB; RARB; RORA; RORA; RORA; RORB; RORB; RORB; RORC; RORC; RORC; RXRA; RXRB; RXRG; THRA; THRA; THRA; VDR; VDR; VDR (inferredBy_Orthology).
PSME4	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."