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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PSMD11

Summary for PSMD11

Gene information	Gene symbol	PSMD11
	Ensembl ID	ENSG00000108671
	Entrez ID	5717
	Gene name	proteasome 26S subunit, non-ATPase 11
	Synonyms	MGC3844\|p44.5\|Rpn6\|S9
	Gene type	protein_coding
	UniProtAcc	O00231

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Dataset with differentially expressed gene: PSMD11

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-0.550888	1.04e-02
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.691357	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.421726	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.298632	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.270646	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.270962	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.281454	6.87e-44
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.622961	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.524002	1.77e-27
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.691273	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.591693	8.29e-35
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.49272	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	0.454362	0.00e+00

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Expression of PSMD11 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PSMD11

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PSMD11

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PSMD11	hsa-miR-765	93.8591	NM_001270482
PSMD11	hsa-miR-2276-3p	92.297	NM_001270482
PSMD11	hsa-miR-5197-3p	92.1362	NM_002815
PSMD11	hsa-miR-11181-3p	91.5916	NM_001270482
PSMD11	hsa-miR-615-3p	90.6244	NM_002815
PSMD11	hsa-miR-607	90.0385	NM_002815
PSMD11	hsa-miR-8068	88.6634	NM_002815
PSMD11	hsa-miR-4316	87.5981	NM_002815
PSMD11	hsa-miR-3671	86.6802	NM_002815
PSMD11	hsa-miR-505-5p	86.5593	NM_001270482
PSMD11	hsa-miR-12136	86.287	NM_002815
PSMD11	hsa-miR-3679-3p	86.1382	NM_001270482
PSMD11	hsa-miR-3150b-3p	85.0258	NM_002815
PSMD11	hsa-miR-5683	84.584	NM_001270482
PSMD11	hsa-miR-3140-3p	84.4709	NM_002815
PSMD11	hsa-miR-4530	83.7968	NM_001270482
PSMD11	hsa-miR-892a	83.563	NM_002815
PSMD11	hsa-miR-659-3p	82.8547	NM_002815
PSMD11	hsa-miR-4784	82.4011	NM_002815
PSMD11	hsa-miR-548aj-3p	82.2405	NM_001270482
PSMD11	hsa-miR-548x-3p	82.2405	NM_001270482
PSMD11	hsa-miR-1277-5p	82.1825	NM_002815
PSMD11	hsa-miR-501-3p	82.0834	NM_002815
PSMD11	hsa-miR-502-3p	82.0834	NM_002815
PSMD11	hsa-miR-4435	82.0053	NM_002815
PSMD11	hsa-miR-6876-5p	81.7837	NM_001270482
PSMD11	hsa-miR-4476	81.7837	NM_001270482
PSMD11	hsa-miR-513a-5p	81.7114	NM_001270482
PSMD11	hsa-miR-196a-5p	80.3754	NM_001270482
PSMD11	hsa-miR-196b-5p	80.3754	NM_001270482
PSMD11	hsa-miR-5190	80.3679	NM_001270482
PSMD11	hsa-miR-4640-5p	80.3489	NM_002815
PSMD11	hsa-miR-18a-3p	80.2743	NM_002815
PSMD11	hsa-miR-4693-5p	80.0533	NM_002815

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Motifs and transcription factors (TFs) regulating PSMD11

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PSMD11	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
PSMD11	metacluster_34.4	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
PSMD11	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
PSMD11	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
PSMD11	taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_repr	ERF; HES7 (directAnnotation).
PSMD11	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
PSMD11	hdpi__ETV4	ETV4 (directAnnotation).
PSMD11	jaspar__MA1122.1	TFDP1 (directAnnotation).
PSMD11	swissregulon__hs__ELF2	ELF2 (directAnnotation).
PSMD11	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
PSMD11	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
PSMD11	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
PSMD11	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
PSMD11	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
PSMD11	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).
PSMD11	taipale_tf_pairs__ELK1_FOXI1_WGTTKMCGGAWRTN_CAP	ELK1; FOXI1 (directAnnotation).
PSMD11	metacluster_135.11	NR2C2 (directAnnotation).
PSMD11	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
PSMD11	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
PSMD11	metacluster_7.13	ZFX (directAnnotation).
PSMD11	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
PSMD11	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
PSMD11	metacluster_160.20	JUND; PRDM15 (directAnnotation).
PSMD11	cisbp__M00341	PAX6 (directAnnotation).
PSMD11	metacluster_198.3	ZFP64 (directAnnotation).
PSMD11	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
PSMD11	cisbp__M00788	ZFY (inferredBy_Orthology).
PSMD11	metacluster_175.1	ZNF283 (directAnnotation).
PSMD11	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
PSMD11	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
PSMD11	metacluster_151.2	ZNF23 (directAnnotation).
PSMD11	transfac_pro__M03806	ZBTB7C (directAnnotation).
PSMD11	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
PSMD11	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
PSMD11	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
PSMD11	jaspar__MA1721.1	ZNF93 (directAnnotation).
PSMD11	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
PSMD11	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
PSMD11	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
PSMD11	cisbp__M01863	ZNF711 (inferredBy_Orthology).
PSMD11	transfac_pro__M12697	ZNF142 (directAnnotation).
PSMD11	transfac_pro__M02786	PLAGL1 (inferredBy_Orthology).
PSMD11	transfac_pro__M01973	PLAG1 (directAnnotation).
PSMD11	tfdimers__MD00483	ZBTB14 (directAnnotation).
PSMD11	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
PSMD11	metacluster_143.13	ZBTB7A (directAnnotation).
PSMD11	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
PSMD11	hdpi__ELF2	ELF2 (directAnnotation).
PSMD11	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
PSMD11	swissregulon__hs__ELK1	ELK1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."