Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PRUNE2

Summary for PRUNE2

Gene information	Gene symbol	PRUNE2
	Ensembl ID	ENSG00000106772
	Entrez ID	158471
	Gene name	prune homolog 2 with BCH domain
	Synonyms	A214N16.3\|bA214N16.3\|BMCC1\|BNIPXL\|C9orf65\|KIAA0367
	Gene type	protein_coding
	UniProtAcc	NA

Top

Dataset with differentially expressed gene: PRUNE2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.60356	0.00e+00

Top

Expression of PRUNE2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to PRUNE2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating PRUNE2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PRUNE2	hsa-miR-5011-5p	98.0425	NM_015225
PRUNE2	hsa-miR-527	96.2432	NM_015225
PRUNE2	hsa-miR-518a-5p	96.2432	NM_015225
PRUNE2	hsa-miR-1827	95.8489	NM_015225
PRUNE2	hsa-miR-30c-5p	95.393	NM_015225
PRUNE2	hsa-miR-30e-5p	95.393	NM_015225
PRUNE2	hsa-miR-30d-5p	95.393	NM_015225
PRUNE2	hsa-miR-30b-5p	95.393	NM_015225
PRUNE2	hsa-miR-30a-5p	95.393	NM_015225
PRUNE2	hsa-miR-182-5p	94.3651	NM_015225
PRUNE2	hsa-miR-1304-5p	93.6348	NM_015225
PRUNE2	hsa-miR-454-3p	93.0035	NM_015225
PRUNE2	hsa-miR-19b-3p	92.9538	NM_015225
PRUNE2	hsa-miR-19a-3p	92.9538	NM_015225
PRUNE2	hsa-miR-4775	92.45	NM_015225
PRUNE2	hsa-miR-12117	92.2939	NM_015225
PRUNE2	hsa-miR-3666	92.258	NM_015225
PRUNE2	hsa-miR-130b-3p	92.258	NM_015225
PRUNE2	hsa-miR-301b-3p	92.258	NM_015225
PRUNE2	hsa-miR-130a-3p	92.258	NM_015225
PRUNE2	hsa-miR-301a-3p	92.258	NM_015225
PRUNE2	hsa-miR-4295	92.258	NM_015225
PRUNE2	hsa-miR-451b	92.0401	NM_015225
PRUNE2	hsa-miR-4446-5p	91.7637	NM_015225
PRUNE2	hsa-miR-4470	90.7014	NM_015225
PRUNE2	hsa-miR-549a-3p	90.7014	NM_015225
PRUNE2	hsa-miR-365a-3p	90.644	NM_015225
PRUNE2	hsa-miR-365b-3p	90.644	NM_015225
PRUNE2	hsa-miR-4762-3p	90.3991	NM_015225
PRUNE2	hsa-miR-6815-3p	89.5837	NM_015225
PRUNE2	hsa-miR-7161-5p	89.4456	NM_015225
PRUNE2	hsa-miR-592	88.8533	NM_015225
PRUNE2	hsa-miR-3163	87.5775	NM_015225
PRUNE2	hsa-miR-548u	86.345	NM_015225
PRUNE2	hsa-miR-4490	86.0833	NM_015225
PRUNE2	hsa-miR-135b-5p	85.9876	NM_015225
PRUNE2	hsa-miR-135a-5p	85.9876	NM_015225
PRUNE2	hsa-miR-330-3p	85.3529	NM_015225
PRUNE2	hsa-miR-8485	85.335	NM_015225
PRUNE2	hsa-miR-4482-3p	85.1492	NM_015225
PRUNE2	hsa-miR-590-3p	84.3925	NM_015225
PRUNE2	hsa-miR-5688	84.3355	NM_015225
PRUNE2	hsa-miR-1257	84.3289	NM_015225
PRUNE2	hsa-miR-4802-5p	84.0153	NM_015225
PRUNE2	hsa-miR-1843	84.0153	NM_015225
PRUNE2	hsa-miR-495-3p	83.6772	NM_015225
PRUNE2	hsa-miR-4680-3p	83.5145	NM_015225
PRUNE2	hsa-miR-3975	81.4886	NM_015225

Page: 1

Top

Motifs and transcription factors (TFs) regulating PRUNE2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PRUNE2	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
PRUNE2	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
PRUNE2	transfac_pro__M02089	E2F3 (directAnnotation).
PRUNE2	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
PRUNE2	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
PRUNE2	transfac_pro__M04817	ZBTB33 (directAnnotation).
PRUNE2	tfdimers__MD00483	ZBTB14 (directAnnotation).
PRUNE2	cisbp__M07938	E2F1 (directAnnotation).
PRUNE2	cisbp__M00968	MTF2 (directAnnotation).
PRUNE2	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
PRUNE2	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
PRUNE2	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
PRUNE2	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
PRUNE2	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."