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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PRRG4

Summary for PRRG4

Gene information	Gene symbol	PRRG4
	Ensembl ID	ENSG00000135378
	Entrez ID	79056
	Gene name	proline rich and Gla domain 4
	Synonyms	TMG4
	Gene type	protein_coding
	UniProtAcc	Q9BZD6

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Dataset with differentially expressed gene: PRRG4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.749148	0.00e+00

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Expression of PRRG4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PRRG4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PRRG4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PRRG4	hsa-miR-561-3p	97.3843	NM_024081
PRRG4	hsa-miR-4778-3p	97.0102	NM_024081
PRRG4	hsa-miR-4659b-3p	95.6933	NM_024081
PRRG4	hsa-miR-4659a-3p	95.6933	NM_024081
PRRG4	hsa-miR-3613-3p	95.6363	NM_024081
PRRG4	hsa-miR-5580-3p	93.731	NM_024081
PRRG4	hsa-miR-1283	91.3243	NM_024081
PRRG4	hsa-miR-4272	90.1916	NM_024081
PRRG4	hsa-miR-335-3p	88.9995	NM_024081
PRRG4	hsa-miR-4517	88.0778	NM_024081
PRRG4	hsa-miR-12136	87.4261	NM_024081
PRRG4	hsa-miR-511-3p	86.9009	NM_024081
PRRG4	hsa-miR-607	86.3652	NM_024081
PRRG4	hsa-miR-4433a-3p	85.1848	NM_024081
PRRG4	hsa-miR-3924	84.87	NM_024081
PRRG4	hsa-miR-6841-3p	83.2439	NM_024081
PRRG4	hsa-miR-508-5p	82.6323	NM_024081
PRRG4	hsa-miR-7151-3p	82.4914	NM_024081
PRRG4	hsa-miR-3194-3p	81.8548	NM_024081
PRRG4	hsa-miR-3148	81.7959	NM_024081
PRRG4	hsa-miR-590-3p	81.5584	NM_024081
PRRG4	hsa-miR-765	81.5149	NM_024081
PRRG4	hsa-miR-302c-5p	81.4414	NM_024081
PRRG4	hsa-miR-4799-5p	81.0903	NM_024081
PRRG4	hsa-miR-9900	81.0504	NM_024081
PRRG4	hsa-miR-583	80.752	NM_024081
PRRG4	hsa-miR-7154-5p	80.2521	NM_024081

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Motifs and transcription factors (TFs) regulating PRRG4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PRRG4	metacluster_135.11	NR2C2 (directAnnotation).
PRRG4	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
PRRG4	tfdimers__MD00038	TFAP2C (directAnnotation).
PRRG4	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
PRRG4	metacluster_7.13	ZFX (directAnnotation).
PRRG4	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
PRRG4	cisbp__M00968	MTF2 (directAnnotation).
PRRG4	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
PRRG4	metacluster_160.20	JUND; PRDM15 (directAnnotation).
PRRG4	cisbp__M00341	PAX6 (directAnnotation).
PRRG4	metacluster_198.3	ZFP64 (directAnnotation).
PRRG4	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
PRRG4	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
PRRG4	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
PRRG4	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
PRRG4	cisbp__M00788	ZFY (inferredBy_Orthology).
PRRG4	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
PRRG4	metacluster_175.1	ZNF283 (directAnnotation).
PRRG4	hdpi__ZNF304	ZNF304 (directAnnotation).
PRRG4	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
PRRG4	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
PRRG4	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
PRRG4	transfac_pro__M01199	TRIM28 (directAnnotation).
PRRG4	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
PRRG4	metacluster_151.2	ZNF23 (directAnnotation).
PRRG4	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
PRRG4	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
PRRG4	transfac_pro__M03806	ZBTB7C (directAnnotation).
PRRG4	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."