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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: PRRC2B

Summary for PRRC2B

Gene informationGene symbol

PRRC2B

Ensembl ID

ENSG00000288701

Entrez ID

84726

Gene nameproline rich coiled-coil 2B
SynonymsBAT2L|BAT2L1|KIAA0515|LQFBS-1|MGC10526
Gene typeprotein_coding
UniProtAcc

NA


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Dataset with differentially expressed gene: PRRC2B

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

PMID34715028

patientsTumor tissueKidney cancerClear cell renal cell carcinoma (ccRCC)ImmunotherapynivolumabpostCD8+ T cells0.3356670.00e+00

GSE131984_JQ1Pal

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)Targeted therapyJQ1 + palbociclibNAMalignant cells0.3346483.31e-18

GSE115251

Kelly cell lineCell lineNeuroblastomaNeuroblastomaTargeted therapyTAE684NAMalignant cells0.5961940.00e+00

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Expression of PRRC2B in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to PRRC2B

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PRRC2B

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
PRRC2Bhsa-miR-570-3p97.7301NM_013318
PRRC2Bhsa-miR-453394.4902NM_013318
PRRC2Bhsa-miR-4753-5p94.4356NM_013318
PRRC2Bhsa-miR-392694.036NM_013318
PRRC2Bhsa-miR-4793-3p93.5034NM_013318
PRRC2Bhsa-miR-500a-3p93.4371NM_013318
PRRC2Bhsa-miR-6777-3p93.1607NM_013318
PRRC2Bhsa-miR-6768-3p92.4026NM_013318
PRRC2Bhsa-miR-442891.7628NM_013318
PRRC2Bhsa-miR-18a-3p91.5775NM_013318
PRRC2Bhsa-miR-6876-5p91.2108NM_013318
PRRC2Bhsa-miR-477990.7571NM_013318
PRRC2Bhsa-miR-488-3p90.0285NM_013318
PRRC2Bhsa-miR-470589.1149NM_013318
PRRC2Bhsa-miR-118488.8617NM_013318
PRRC2Bhsa-miR-651-3p88.4523NM_013318
PRRC2Bhsa-miR-447687.8888NM_013318
PRRC2Bhsa-miR-10394-5p87.8484NM_013318
PRRC2Bhsa-miR-397887.7242NM_013318
PRRC2Bhsa-miR-3074-5p87.4921NM_013318
PRRC2Bhsa-miR-426187.2959NM_013318
PRRC2Bhsa-miR-6756-3p87.1476NM_013318
PRRC2Bhsa-miR-3127-3p87.1476NM_013318
PRRC2Bhsa-miR-1252-5p86.8998NM_013318
PRRC2Bhsa-miR-7109-3p86.6627NM_013318
PRRC2Bhsa-miR-3616-3p85.9261NM_013318
PRRC2Bhsa-miR-6891-5p85.7476NM_013318
PRRC2Bhsa-miR-445685.6507NM_013318
PRRC2Bhsa-miR-466085.4893NM_013318
PRRC2Bhsa-miR-120584.9497NM_013318
PRRC2Bhsa-miR-3688-3p84.7573NM_013318
PRRC2Bhsa-miR-428384.2415NM_013318
PRRC2Bhsa-miR-1211883.9251NM_013318
PRRC2Bhsa-miR-92b-3p83.8345NM_013318
PRRC2Bhsa-miR-92a-3p83.8345NM_013318
PRRC2Bhsa-miR-32-5p83.8345NM_013318
PRRC2Bhsa-miR-76583.7663NM_013318
PRRC2Bhsa-miR-3173-3p83.129NM_013318
PRRC2Bhsa-miR-510-3p82.946NM_013318
PRRC2Bhsa-miR-6880-5p82.241NM_013318
PRRC2Bhsa-miR-3619-5p81.8106NM_013318
PRRC2Bhsa-miR-494-3p81.4927NM_013318
PRRC2Bhsa-miR-367-3p81.2608NM_013318
PRRC2Bhsa-miR-25-3p81.2608NM_013318
PRRC2Bhsa-miR-363-3p81.2608NM_013318
PRRC2Bhsa-miR-221-3p80.3755NM_013318
PRRC2Bhsa-miR-222-3p80.3755NM_013318
PRRC2Bhsa-miR-147b-5p80.1657NM_013318
PRRC2Bhsa-miR-367180.1514NM_013318
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Motifs and transcription factors (TFs) regulating PRRC2B

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
PRRC2Btransfac_pro__M05791ZNF517 (directAnnotation).
PRRC2Bkznf__ZNF135_Isakova2017_SMiLE-seqZNF135 (directAnnotation).
PRRC2Bhomer__YCTTTGTTCC_Sox4SOX4 (inferredBy_Orthology).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."