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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: PROS1

Summary for PROS1

Gene information	Gene symbol	PROS1
	Ensembl ID	ENSG00000184500
	Entrez ID	5627
	Gene name	protein S
	Synonyms	PROS
	Gene type	protein_coding
	UniProtAcc	P07225

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Dataset with differentially expressed gene: PROS1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.327029	1.35e-25

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Expression of PROS1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PROS1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PROS1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PROS1	hsa-miR-4282	98.1155	NM_001314077
PROS1	hsa-miR-494-3p	94.7633	NM_001314077
PROS1	hsa-miR-3163	94.3355	NM_001314077
PROS1	hsa-miR-4693-5p	92.4251	NM_001314077
PROS1	hsa-miR-4790-3p	91.3155	NM_001314077
PROS1	hsa-miR-633	91.0545	NM_001314077
PROS1	hsa-miR-6830-5p	89.4756	NM_001314077
PROS1	hsa-miR-3682-3p	89.197	NM_001314077
PROS1	hsa-miR-8065	87.8662	NM_001314077
PROS1	hsa-miR-380-3p	87.7258	NM_001314077
PROS1	hsa-miR-510-3p	86.9027	NM_001314077
PROS1	hsa-miR-3941	86.47	NM_001314077
PROS1	hsa-miR-5001-3p	86.1623	NM_001314077
PROS1	hsa-miR-10397-5p	84.6976	NM_001314077
PROS1	hsa-miR-4457	84.4285	NM_001314077
PROS1	hsa-miR-451b	83.8806	NM_001314077
PROS1	hsa-miR-4678	83.0937	NM_001314077
PROS1	hsa-miR-514a-5p	81.3119	NM_001314077
PROS1	hsa-miR-29b-1-5p	81.1384	NM_001314077
PROS1	hsa-miR-2052	80.2084	NM_001314077

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Motifs and transcription factors (TFs) regulating PROS1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PROS1	metacluster_135.11	NR2C2 (directAnnotation).
PROS1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
PROS1	cisbp__M00968	MTF2 (directAnnotation).
PROS1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
PROS1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
PROS1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
PROS1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
PROS1	metacluster_175.1	ZNF283 (directAnnotation).
PROS1	transfac_pro__M03806	ZBTB7C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
PROS1	"Drotrecogin alfa"	DB00055	biotech
PROS1	"Kappadione"	DB09332	small molecule
PROS1	"Menadione"	DB00170	small molecule
PROS1	"Sodium tetradecyl sulfate"	DB00464	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."