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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PROM2

Summary for PROM2

Gene information	Gene symbol	PROM2
	Ensembl ID	ENSG00000155066
	Entrez ID	150696
	Gene name	prominin 2
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q8N271

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Dataset with differentially expressed gene: PROM2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.403093	0.00e+00

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Expression of PROM2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PROM2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PROM2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PROM2	hsa-miR-6731-3p	96.1217	NM_001165977
PROM2	hsa-miR-495-3p	93.5747	NM_144707
PROM2	hsa-miR-5688	93.5747	NM_144707
PROM2	hsa-miR-548p	92.264	NM_001165977
PROM2	hsa-miR-1266-5p	89.6764	NM_144707
PROM2	hsa-miR-6738-3p	88.5787	NM_144707
PROM2	hsa-miR-520b-5p	87.7369	NM_144707
PROM2	hsa-miR-519a-2-5p	87.7369	NM_144707
PROM2	hsa-miR-6825-5p	86.6536	NM_001165978
PROM2	hsa-miR-4518	85.4855	NM_144707
PROM2	hsa-miR-4526	85.4629	NM_001165977
PROM2	hsa-miR-3660	85.4629	NM_001165977
PROM2	hsa-miR-5001-3p	84.1546	NM_144707
PROM2	hsa-miR-10526-3p	83.0158	NM_001165978
PROM2	hsa-miR-369-3p	82.8279	NM_001165977
PROM2	hsa-miR-4516	82.4137	NM_001165978
PROM2	hsa-miR-29b-1-5p	81.7913	NM_001165978
PROM2	hsa-miR-4498	81.4548	NM_144707
PROM2	hsa-miR-1827	80.5144	NM_001165978

Page: 1

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Motifs and transcription factors (TFs) regulating PROM2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."