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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PRMT2

Summary for PRMT2

Gene information	Gene symbol	PRMT2
	Ensembl ID	ENSG00000160310
	Entrez ID	3275
	Gene name	protein arginine methyltransferase 2
	Synonyms	HRMT1L1\|MGC111373
	Gene type	protein_coding
	UniProtAcc	P55345

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Dataset with differentially expressed gene: PRMT2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	CD8+ T cells	0.266854	2.25e-35
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	NK cells	0.303951	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.548375	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.372036	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.435903	0.00e+00
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	pre	NK cells	0.424309	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	0.329379	1.83e-16
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.252766	3.13e-02
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	post	NK cells	0.298733	6.49e-28
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	NK cells	0.360837	7.44e-34
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	CD8+ T cells	0.3589	0.00e+00
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	CD4+ T cells	0.325562	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.653029	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.351344	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	0.793528	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.46533	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.351456	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.338296	0.00e+00

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Expression of PRMT2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PRMT2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PRMT2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PRMT2	hsa-miR-95-5p	96.5427	NM_001286676
PRMT2	hsa-miR-3613-3p	93.5506	NM_001242865
PRMT2	hsa-miR-335-3p	92.9022	NM_001242866
PRMT2	hsa-miR-3190-3p	89.9264	NM_001286676
PRMT2	hsa-miR-5581-3p	89.4926	NM_001242866
PRMT2	hsa-miR-4697-3p	87.6188	NM_001242865
PRMT2	hsa-miR-7162-3p	86.0148	NM_001242865
PRMT2	hsa-miR-4762-3p	85.3081	NM_001242865
PRMT2	hsa-miR-374b-3p	84.9201	NM_001242865
PRMT2	hsa-miR-138-2-3p	84.7805	NM_001242865
PRMT2	hsa-miR-3650	84.4377	NM_001242865
PRMT2	hsa-miR-3148	84.187	NM_001242866
PRMT2	hsa-miR-6890-3p	83.9929	NM_001242865
PRMT2	hsa-miR-4463	82.4971	NM_001242866
PRMT2	hsa-miR-6516-5p	82.3319	NM_001242865
PRMT2	hsa-miR-4282	82.2885	NM_001286676
PRMT2	hsa-miR-6738-3p	81.9764	NM_001242866
PRMT2	hsa-miR-140-3p	80.932	NM_001242866
PRMT2	hsa-miR-499b-5p	80.254	NM_001242865

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Motifs and transcription factors (TFs) regulating PRMT2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PRMT2	transfac_pro__M05479	ZNF580 (directAnnotation).
PRMT2	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
PRMT2	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
PRMT2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
PRMT2	transfac_pro__M00652	NRF1 (directAnnotation).
PRMT2	transfac_pro__M04866	HDAC2 (directAnnotation).
PRMT2	transfac_pro__M02113	POU2AF1 (directAnnotation).
PRMT2	jaspar__MA1939.1	SREBF2 (directAnnotation).
PRMT2	kznf__ZNF184_Schmitges2016_RCADE	ZNF184 (directAnnotation).
PRMT2	hocomoco__PO5F1_HUMAN.H11MO.1.A	POU5F1 (directAnnotation).
PRMT2	kznf__ZSCAN29_TF_Evolution_PBM	ZSCAN29 (directAnnotation).
PRMT2	metacluster_85.7	ZSCAN29; ZSCAN29 (directAnnotation).
PRMT2	metacluster_22.15	BACH1 (directAnnotation).
PRMT2	metacluster_22.14	BACH1 (inferredBy_Orthology).
PRMT2	taipale_tf_pairs__PITX1_HOXA3_TAATKRNNNNGGATTA_CAP	HOXA3; PITX1 (directAnnotation).
PRMT2	tfdimers__MD00415	PDX1; POU3F2 (directAnnotation).
PRMT2	tfdimers__MD00302	IRF7; IRF8 (directAnnotation).
PRMT2	hdpi__PQBP1	PQBP1 (directAnnotation).
PRMT2	tfdimers__MD00007	E2F1; IRF8 (directAnnotation).
PRMT2	transfac_pro__M02109	NKX2-2 (directAnnotation).
PRMT2	transfac_pro__M06806	PEG3 (directAnnotation).
PRMT2	transfac_public__M00416	ALX1 (directAnnotation).
PRMT2	metacluster_70.17	POU1F1 (directAnnotation).
PRMT2	tfdimers__MD00414	IRF1; IRF2; IRF3; IRF4; IRF5; IRF7; IRF8; IRF9; POU5F1 (directAnnotation).
PRMT2	transfac_pro__M04849	RELA (directAnnotation).
PRMT2	transfac_pro__M05842	ZBTB41 (inferredBy_Orthology).
PRMT2	tfdimers__MD00439	ATF1; HOXA13 (directAnnotation).
PRMT2	metacluster_1.9	CDX1; CDX1; CDX2; CDX2; CDX2; CDX4; CDX4; EVX1; HOXA10; HOXA10; HOXA10; HOXA10; HOXA10; HOXA10; HOXA11; HOXA11; HOXA11; HOXA13; HOXA13; HOXA13; HOXA13; HOXA13; HOXB13; HOXB13; HOXB13; HOXB13; HOXB13; HOXB9; HOXB9; HOXC10; HOXC10; HOXC10; HOXC10; HOXC10; HOXC11; HOXC11; HOXC11; HOXC11; HOXC11; HOXC11; HOXC12; HOXC12; HOXC12; HOXC13; HOXC13; HOXC9; HOXC9; HOXD10; HOXD10; HOXD10; HOXD10; HOXD10; HOXD11; HOXD11; HOXD12; HOXD13; HOXD13; HOXD13; HOXD13; HOXD13; HOXD13; HOXD9; HOXD9; HOXD9; HOXD9; ZNF843 (directAnnotation). CDX1; CDX4; CDX4; DBX2; HOXA11; HOXA13; HOXA13; HOXA9; HOXB13; HOXC11; HOXC13; HOXD10; HOXD12; HOXD12; HOXD13; HOXD13; HOXD9; HOXD9 (inferredBy_Orthology).
PRMT2	transfac_pro__M05879	ZNF713 (directAnnotation).
PRMT2	tfdimers__MD00247	CRX; HOXA10 (directAnnotation).
PRMT2	tfdimers__MD00527	IRF1; IRF2; IRF3; IRF4; IRF5; IRF6; IRF7; IRF8; ZEB1 (directAnnotation).
PRMT2	cisbp__M00294	HOXD13 (directAnnotation).
PRMT2	tfdimers__MD00499	POU5F1; TAF6; TBP (directAnnotation).
PRMT2	dbtfbs__SETDB1_HEK293_ENCSR348AGV_merged_N1	SETDB1 (directAnnotation).
PRMT2	tfdimers__MD00147	ELF5; TFAP2C (directAnnotation).
PRMT2	transfac_pro__M06196	ZNF81 (directAnnotation).
PRMT2	transfac_public__M00240	NKX2-5 (directAnnotation).
PRMT2	tfdimers__MD00165	CRX; FOS; FOSB; FOSL1; FOSL2; JUN; JUNB; JUND (directAnnotation).
PRMT2	cisbp__M00212	SOX13 (inferredBy_Orthology).
PRMT2	hdpi__FLI1	FLI1 (directAnnotation).
PRMT2	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
PRMT2	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
PRMT2	taipale_tf_pairs__ETV2_PITX1_RSCGGAANNNNNGGMTTAN_CAP	ETV2; PITX1 (directAnnotation).
PRMT2	kznf__ZNF441_Imbeault2017_OM_RCADE	ZNF441 (directAnnotation).
PRMT2	transfac_pro__M06104	ZNF16 (directAnnotation).
PRMT2	tfdimers__MD00208	IRF1; LTF (directAnnotation).
PRMT2	taipale_tf_pairs__ETV2_DLX3_RSCGGAANNNNNNNTAATKR_CAP_repr	DLX3; ETV2 (directAnnotation).
PRMT2	taipale_cyt_meth__POU5F1_NYTAATTATGCGNRN_FL_meth_repr	POU5F1 (directAnnotation).
PRMT2	tfdimers__MD00270	DBX2; HMGA1; HMGA2 (directAnnotation).
PRMT2	metacluster_178.5	PAX3; ZNF337; ZNF337 (directAnnotation). PAX3 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."