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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: PRKCQ

Summary for PRKCQ

Gene information	Gene symbol	PRKCQ
	Ensembl ID	ENSG00000065675
	Entrez ID	5588
	Gene name	protein kinase C theta
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q04759

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Dataset with differentially expressed gene: PRKCQ

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-0.99672	2.56e-04

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Expression of PRKCQ in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PRKCQ

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PRKCQ

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PRKCQ	hsa-miR-627-3p	98.7507	NM_001323266
PRKCQ	hsa-miR-3606-5p	95.5548	NM_001242413
PRKCQ	hsa-miR-1297	93.305	NM_001242413
PRKCQ	hsa-miR-26a-5p	91.7386	NM_001242413
PRKCQ	hsa-miR-26b-5p	91.7386	NM_001242413
PRKCQ	hsa-miR-4465	91.1537	NM_001242413
PRKCQ	hsa-miR-5003-5p	90.5798	NM_001323266
PRKCQ	hsa-miR-548v	88.9212	NM_001323266
PRKCQ	hsa-miR-3659	86.1542	NM_001242413
PRKCQ	hsa-miR-578	85.6602	NM_001323266
PRKCQ	hsa-miR-6764-5p	82.287	NM_001323266
PRKCQ	hsa-miR-4658	81.9778	NM_001242413
PRKCQ	hsa-miR-6790-5p	81.9778	NM_001242413
PRKCQ	hsa-miR-921	81.4782	NM_001242413
PRKCQ	hsa-miR-4677-3p	81.1168	NM_001323266

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Motifs and transcription factors (TFs) regulating PRKCQ

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
PRKCQ	"Dexfosfoserine"	DB04522	small molecule
PRKCQ	"Fostamatinib"	DB12010	small molecule
PRKCQ	"Phosphonothreonine"	DB02482	small molecule
PRKCQ	"Staurosporine"	DB02010	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."