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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: PRKCI

Summary for PRKCI

Gene information	Gene symbol	PRKCI
	Ensembl ID	ENSG00000163558
	Entrez ID	5584
	Gene name	protein kinase C iota
	Synonyms	DXS1179E\|PKCI
	Gene type	protein_coding
	UniProtAcc	P41743

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Dataset with differentially expressed gene: PRKCI

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.274159	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.250285	9.77e-19

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Expression of PRKCI in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PRKCI

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PRKCI

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PRKCI	hsa-miR-345-3p	96.678	NM_002740
PRKCI	hsa-miR-3163	95.6761	NM_002740
PRKCI	hsa-miR-3973	95.6159	NM_002740
PRKCI	hsa-miR-6867-5p	94.2794	NM_002740
PRKCI	hsa-miR-548ac	94.146	NM_002740
PRKCI	hsa-miR-548d-3p	94.146	NM_002740
PRKCI	hsa-miR-548h-3p	94.146	NM_002740
PRKCI	hsa-miR-548bb-3p	94.146	NM_002740
PRKCI	hsa-miR-548z	94.146	NM_002740
PRKCI	hsa-miR-548aj-3p	93.5715	NM_002740
PRKCI	hsa-miR-548x-3p	93.5715	NM_002740
PRKCI	hsa-miR-5581-3p	93.4702	NM_002740
PRKCI	hsa-miR-548aw	93.037	NM_002740
PRKCI	hsa-miR-4698	92.7435	NM_002740
PRKCI	hsa-miR-3688-5p	92.5376	NM_002740
PRKCI	hsa-miR-549a-5p	92.1634	NM_002740
PRKCI	hsa-miR-6499-3p	91.6767	NM_002740
PRKCI	hsa-miR-548aq-3p	90.8821	NM_002740
PRKCI	hsa-miR-548ae-3p	90.8821	NM_002740
PRKCI	hsa-miR-548j-3p	90.8821	NM_002740
PRKCI	hsa-miR-548ah-3p	90.8821	NM_002740
PRKCI	hsa-miR-548am-3p	90.8821	NM_002740
PRKCI	hsa-miR-196a-3p	90.3047	NM_002740
PRKCI	hsa-miR-6815-5p	89.8905	NM_002740
PRKCI	hsa-miR-6865-5p	89.8905	NM_002740
PRKCI	hsa-miR-616-5p	88.8881	NM_002740
PRKCI	hsa-miR-371b-5p	88.8881	NM_002740
PRKCI	hsa-miR-373-5p	88.8881	NM_002740
PRKCI	hsa-miR-630	88.5521	NM_002740
PRKCI	hsa-miR-3140-5p	88.0037	NM_002740
PRKCI	hsa-miR-6799-5p	87.2751	NM_002740
PRKCI	hsa-miR-335-3p	87.2448	NM_002740
PRKCI	hsa-miR-6891-3p	86.9988	NM_002740
PRKCI	hsa-miR-6072	86.9988	NM_002740
PRKCI	hsa-miR-5692a	86.7532	NM_002740
PRKCI	hsa-miR-4775	86.0533	NM_002740
PRKCI	hsa-miR-1277-5p	85.7202	NM_002740
PRKCI	hsa-miR-6759-5p	85.3829	NM_002740
PRKCI	hsa-miR-32-3p	85.2786	NM_002740
PRKCI	hsa-miR-648	85.2336	NM_002740
PRKCI	hsa-miR-609	85.0585	NM_002740
PRKCI	hsa-miR-12136	84.7711	NM_002740
PRKCI	hsa-miR-7161-5p	84.4776	NM_002740
PRKCI	hsa-miR-1468-3p	84.4117	NM_002740
PRKCI	hsa-miR-203a-3p	83.9883	NM_002740
PRKCI	hsa-miR-548u	82.1469	NM_002740
PRKCI	hsa-miR-4742-3p	81.3111	NM_002740
PRKCI	hsa-miR-651-3p	80.996	NM_002740
PRKCI	hsa-miR-586	80.7496	NM_002740
PRKCI	hsa-miR-4743-3p	80.5359	NM_002740

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Motifs and transcription factors (TFs) regulating PRKCI

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PRKCI	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
PRKCI	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
PRKCI	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
PRKCI	metacluster_175.1	ZNF283 (directAnnotation).
PRKCI	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
PRKCI	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
PRKCI	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
PRKCI	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
PRKCI	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
PRKCI	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
PRKCI	"Bisindolylmaleimide I"	DB03777	small molecule
PRKCI	"Fostamatinib"	DB12010	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."