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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: PRKCA

Summary for PRKCA

Gene information	Gene symbol	PRKCA
	Ensembl ID	ENSG00000154229
	Entrez ID	5578
	Gene name	protein kinase C alpha
	Synonyms	PKCA\|PKCalpha
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: PRKCA

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.853911	2.78e-08
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.290825	3.65e-16
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.323175	0.00e+00

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Expression of PRKCA in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PRKCA

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
PRKCA	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating PRKCA

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PRKCA	hsa-miR-6878-3p	99.2354	NM_002737
PRKCA	hsa-miR-6744-3p	99.2242	NM_002737
PRKCA	hsa-miR-4757-5p	99.1191	NM_002737
PRKCA	hsa-miR-8485	98.8556	NM_002737
PRKCA	hsa-miR-6781-3p	97.4429	NM_002737
PRKCA	hsa-miR-2682-3p	97.0975	NM_002737
PRKCA	hsa-miR-5692a	97.039	NM_002737
PRKCA	hsa-miR-340-5p	96.0775	NM_002737
PRKCA	hsa-miR-4282	95.8191	NM_002737
PRKCA	hsa-miR-92a-1-5p	95.4029	NM_002737
PRKCA	hsa-miR-1275	95.1305	NM_002737
PRKCA	hsa-miR-185-3p	94.5938	NM_002737
PRKCA	hsa-miR-4283	94.5842	NM_002737
PRKCA	hsa-miR-548p	94.0888	NM_002737
PRKCA	hsa-miR-12119	93.7005	NM_002737
PRKCA	hsa-miR-1468-3p	93.6292	NM_002737
PRKCA	hsa-miR-4489	92.8591	NM_002737
PRKCA	hsa-miR-4668-3p	91.998	NM_002737
PRKCA	hsa-miR-6846-5p	91.8452	NM_002737
PRKCA	hsa-miR-6848-5p	91.8452	NM_002737
PRKCA	hsa-miR-150-5p	91.2329	NM_002737
PRKCA	hsa-miR-1266-3p	91.0703	NM_002737
PRKCA	hsa-miR-4665-5p	90.8224	NM_002737
PRKCA	hsa-miR-3163	90.0518	NM_002737
PRKCA	hsa-miR-6751-5p	89.9088	NM_002737
PRKCA	hsa-miR-500a-5p	89.8194	NM_002737
PRKCA	hsa-miR-12117	89.7758	NM_002737
PRKCA	hsa-miR-6868-3p	89.7049	NM_002737
PRKCA	hsa-miR-532-3p	89.6941	NM_002737
PRKCA	hsa-miR-548x-3p	89.401	NM_002737
PRKCA	hsa-miR-548aj-3p	89.401	NM_002737
PRKCA	hsa-miR-6792-5p	89.2856	NM_002737
PRKCA	hsa-miR-4711-3p	88.9389	NM_002737
PRKCA	hsa-miR-6799-5p	88.8604	NM_002737
PRKCA	hsa-miR-4784	88.6554	NM_002737
PRKCA	hsa-miR-3150b-3p	88.6554	NM_002737
PRKCA	hsa-miR-652-5p	88.574	NM_002737
PRKCA	hsa-miR-5582-3p	88.5113	NM_002737
PRKCA	hsa-miR-6764-3p	88.2388	NM_002737
PRKCA	hsa-miR-2116-3p	88.1057	NM_002737
PRKCA	hsa-miR-548ae-3p	87.677	NM_002737
PRKCA	hsa-miR-548aq-3p	87.677	NM_002737
PRKCA	hsa-miR-548j-3p	87.677	NM_002737
PRKCA	hsa-miR-548ah-3p	87.677	NM_002737
PRKCA	hsa-miR-548am-3p	87.677	NM_002737
PRKCA	hsa-miR-9500	87.5457	NM_002737
PRKCA	hsa-miR-516a-3p	87.5362	NM_002737
PRKCA	hsa-miR-516b-3p	87.5362	NM_002737
PRKCA	hsa-miR-7162-5p	87.5362	NM_002737
PRKCA	hsa-miR-548n	87.5166	NM_002737

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Motifs and transcription factors (TFs) regulating PRKCA

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PRKCA	transfac_pro__M06074	ZNF732 (directAnnotation).
PRKCA	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
PRKCA	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
PRKCA	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
PRKCA	transfac_pro__M04617	ZBTB7A (directAnnotation).
PRKCA	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
PRKCA	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
PRKCA	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
PRKCA	transfac_pro__M07387	ZBTB7A (directAnnotation).
PRKCA	transfac_pro__M07436	WT1 (directAnnotation).
PRKCA	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
PRKCA	transfac_pro__M00716	ZBTB14 (directAnnotation).
PRKCA	swissregulon__hs__CHD1	CHD1 (directAnnotation).
PRKCA	hdpi__HIP2	UBE2K (directAnnotation).
PRKCA	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
PRKCA	transfac_pro__M04893	TAF1 (directAnnotation).
PRKCA	transfac_pro__M03876	ZBTB33 (directAnnotation).
PRKCA	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
PRKCA	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
PRKCA	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
PRKCA	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
PRKCA	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
PRKCA	jaspar__MA0079.5	SP1 (directAnnotation).
PRKCA	transfac_pro__M01253	CNOT3 (directAnnotation).
PRKCA	metacluster_153.4	SOX12; SOX14; SRY (directAnnotation). SOX5 (inferredBy_Orthology).
PRKCA	transfac_pro__M04817	ZBTB33 (directAnnotation).
PRKCA	cisbp__M07938	E2F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
PRKCA	"alpha-Tocopherol succinate"	DB14001	small molecule
PRKCA	"Aprinocarsen"	DB06451	biotech
PRKCA	"Bryostatin 1"	DB11752	small molecule
PRKCA	"D-alpha-Tocopherol acetate"	DB14002	small molecule
PRKCA	"Ellagic acid"	DB08846	small molecule
PRKCA	"Ingenol mebutate"	DB05013	small molecule
PRKCA	"Midostaurin"	DB06595	small molecule
PRKCA	"Perifosine"	DB06641	small molecule
PRKCA	"Phosphatidyl serine"	DB00144	small molecule
PRKCA	"Vitamin E"	DB00163	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."