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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: PRKAR2A

Summary for PRKAR2A

Gene information	Gene symbol	PRKAR2A
	Ensembl ID	ENSG00000114302
	Entrez ID	5576
	Gene name	protein kinase cAMP-dependent type II regulatory subunit alpha
	Synonyms	PRKAR2
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: PRKAR2A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.262962	3.92e-44
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.356651	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.25828	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.837811	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.520459	0.00e+00

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Expression of PRKAR2A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PRKAR2A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PRKAR2A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PRKAR2A	hsa-miR-664b-5p	95.3993	NM_004157
PRKAR2A	hsa-miR-589-5p	94.8531	NM_004157
PRKAR2A	hsa-miR-6853-3p	92.579	NM_001321982
PRKAR2A	hsa-miR-520g-3p	92.427	NM_004157
PRKAR2A	hsa-miR-520h	92.427	NM_004157
PRKAR2A	hsa-miR-6715b-5p	92.1608	NM_004157
PRKAR2A	hsa-miR-4269	92.1608	NM_004157
PRKAR2A	hsa-miR-31-5p	91.059	NM_004157
PRKAR2A	hsa-miR-451b	89.0957	NM_004157
PRKAR2A	hsa-miR-4306	88.9138	NM_004157
PRKAR2A	hsa-miR-4680-3p	88.7054	NM_001321982
PRKAR2A	hsa-miR-4742-5p	88.6165	NM_004157
PRKAR2A	hsa-miR-4692	88.6165	NM_004157
PRKAR2A	hsa-miR-6761-5p	88.0484	NM_004157
PRKAR2A	hsa-miR-4251	87.7879	NM_004157
PRKAR2A	hsa-miR-185-5p	87.5329	NM_004157
PRKAR2A	hsa-miR-4644	87.5329	NM_004157
PRKAR2A	hsa-miR-548l	87.4793	NM_001321982
PRKAR2A	hsa-miR-512-3p	87.4546	NM_004157
PRKAR2A	hsa-miR-1252-5p	86.9803	NM_004157
PRKAR2A	hsa-miR-4470	86.6702	NM_004157
PRKAR2A	hsa-miR-8080	86.1118	NM_004157
PRKAR2A	hsa-miR-196a-1-3p	86.0984	NM_001321982
PRKAR2A	hsa-miR-4743-3p	85.9832	NM_004157
PRKAR2A	hsa-miR-3120-3p	85.7261	NM_001321982
PRKAR2A	hsa-miR-4514	85.6728	NM_004157
PRKAR2A	hsa-miR-3928-3p	85.5461	NM_001321982
PRKAR2A	hsa-miR-7155-5p	84.6633	NM_004157
PRKAR2A	hsa-miR-4291	84.2188	NM_004157
PRKAR2A	hsa-miR-4500	84.2147	NM_004157
PRKAR2A	hsa-miR-12115	84.0819	NM_004157
PRKAR2A	hsa-miR-6782-3p	83.9976	NM_001321982
PRKAR2A	hsa-miR-3173-5p	83.9119	NM_004157
PRKAR2A	hsa-miR-6799-3p	83.9119	NM_004157
PRKAR2A	hsa-miR-767-3p	83.7268	NM_001321982
PRKAR2A	hsa-miR-379-3p	83.5405	NM_001321982
PRKAR2A	hsa-miR-411-3p	83.5405	NM_001321982
PRKAR2A	hsa-miR-585-5p	82.9569	NM_004157
PRKAR2A	hsa-miR-922	82.8083	NM_004157
PRKAR2A	hsa-miR-3529-3p	82.4512	NM_001321982
PRKAR2A	hsa-miR-3618	81.7246	NM_004157
PRKAR2A	hsa-miR-3133	80.6297	NM_004157
PRKAR2A	hsa-miR-195-5p	80.232	NM_004157
PRKAR2A	hsa-miR-15b-5p	80.232	NM_004157
PRKAR2A	hsa-miR-16-5p	80.232	NM_004157
PRKAR2A	hsa-miR-15a-5p	80.232	NM_004157
PRKAR2A	hsa-miR-7847-3p	80.1735	NM_004157
PRKAR2A	hsa-miR-3138	80.016	NM_001321982

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Motifs and transcription factors (TFs) regulating PRKAR2A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PRKAR2A	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
PRKAR2A	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
PRKAR2A	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
PRKAR2A	transfac_pro__M04950	EGR1 (directAnnotation).
PRKAR2A	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
PRKAR2A	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
PRKAR2A	transfac_pro__M00652	NRF1 (directAnnotation).
PRKAR2A	transfac_pro__M04866	HDAC2 (directAnnotation).
PRKAR2A	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
PRKAR2A	hdpi__TP73	TP73 (directAnnotation).
PRKAR2A	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
PRKAR2A	"GEM-231"	DB05798	biotech

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."