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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PRKAB2

Summary for PRKAB2

Gene information	Gene symbol	PRKAB2
	Ensembl ID	ENSG00000131791
	Entrez ID	5565
	Gene name	protein kinase AMP-activated non-catalytic subunit beta 2
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	O43741

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Dataset with differentially expressed gene: PRKAB2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.491054	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.429318	0.00e+00

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Expression of PRKAB2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PRKAB2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PRKAB2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PRKAB2	hsa-miR-4310	96.5699	NM_005399
PRKAB2	hsa-miR-5003-3p	96.0931	NM_005399
PRKAB2	hsa-miR-7853-5p	95.5262	NM_005399
PRKAB2	hsa-miR-105-5p	94.8546	NM_005399
PRKAB2	hsa-miR-378g	94.7935	NM_005399
PRKAB2	hsa-miR-1250-3p	94.6462	NM_005399
PRKAB2	hsa-miR-7157-5p	94.4597	NM_005399
PRKAB2	hsa-miR-6730-3p	93.4326	NM_005399
PRKAB2	hsa-miR-4251	92.9754	NM_005399
PRKAB2	hsa-miR-29c-3p	92.0028	NM_005399
PRKAB2	hsa-miR-29b-3p	92.0028	NM_005399
PRKAB2	hsa-miR-29a-3p	92.0028	NM_005399
PRKAB2	hsa-miR-498-3p	91.0854	NM_005399
PRKAB2	hsa-miR-5688	89.9395	NM_005399
PRKAB2	hsa-miR-4695-5p	89.8471	NM_005399
PRKAB2	hsa-miR-3148	89.6599	NM_005399
PRKAB2	hsa-miR-4519	89.6246	NM_005399
PRKAB2	hsa-miR-1227-3p	88.8627	NM_005399
PRKAB2	hsa-miR-153-5p	87.4857	NM_005399
PRKAB2	hsa-miR-330-3p	87.2783	NM_005399
PRKAB2	hsa-miR-548e-5p	86.1061	NM_005399
PRKAB2	hsa-miR-3152-3p	85.4685	NM_005399
PRKAB2	hsa-miR-767-5p	85.4193	NM_005399
PRKAB2	hsa-miR-5010-3p	85.1548	NM_005399
PRKAB2	hsa-miR-495-3p	84.6635	NM_005399
PRKAB2	hsa-miR-448	83.5875	NM_005399
PRKAB2	hsa-miR-5088-3p	83.0224	NM_005399
PRKAB2	hsa-miR-5001-3p	82.7888	NM_005399
PRKAB2	hsa-miR-561-3p	82.7205	NM_005399
PRKAB2	hsa-miR-6739-5p	82.3919	NM_005399
PRKAB2	hsa-miR-6733-5p	82.3919	NM_005399
PRKAB2	hsa-miR-664b-5p	82.3832	NM_005399
PRKAB2	hsa-miR-12135	81.8848	NM_005399
PRKAB2	hsa-miR-4306	81.6296	NM_005399
PRKAB2	hsa-miR-4668-5p	81.0586	NM_005399
PRKAB2	hsa-miR-494-3p	80.3643	NM_005399
PRKAB2	hsa-miR-4661-3p	80.2124	NM_005399
PRKAB2	hsa-miR-455-3p	80.0654	NM_005399

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Motifs and transcription factors (TFs) regulating PRKAB2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PRKAB2	metacluster_7.13	ZFX (directAnnotation).
PRKAB2	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
PRKAB2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
PRKAB2	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
PRKAB2	jaspar__MA0079.5	SP1 (directAnnotation).
PRKAB2	cisbp__M00968	MTF2 (directAnnotation).
PRKAB2	cisbp__M00341	PAX6 (directAnnotation).
PRKAB2	metacluster_198.3	ZFP64 (directAnnotation).
PRKAB2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
PRKAB2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
PRKAB2	cisbp__M00788	ZFY (inferredBy_Orthology).
PRKAB2	hdpi__ZNF304	ZNF304 (directAnnotation).
PRKAB2	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
PRKAB2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
PRKAB2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
PRKAB2	transfac_pro__M03806	ZBTB7C (directAnnotation).
PRKAB2	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."