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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PRCP

Summary for PRCP

Gene information	Gene symbol	PRCP
	Ensembl ID	ENSG00000137509
	Entrez ID	5547
	Gene name	prolylcarboxypeptidase
	Synonyms	HUMPCP\|PCP
	Gene type	protein_coding
	UniProtAcc	P42785

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Dataset with differentially expressed gene: PRCP

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	cDCs	0.350942	6.04e-05
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.326887	2.69e-30
GSE162117	patients	Peripheral blood mononuclear cells	Acute myeloid leukemia	Tefractory acute myeloid leukemia (AML)	Targeted therapy	ficlatuzumab	post	cDCs	-0.288278	4.31e-15

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Expression of PRCP in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PRCP

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PRCP

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PRCP	hsa-miR-4328	96.7555	NM_005040
PRCP	hsa-miR-4469	91.6459	NM_005040
PRCP	hsa-miR-6730-5p	90.6318	NM_001319214
PRCP	hsa-miR-6081	89.7334	NM_005040
PRCP	hsa-miR-4680-5p	89.4385	NM_005040
PRCP	hsa-miR-520h	89.2085	NM_005040
PRCP	hsa-miR-520g-3p	89.2085	NM_005040
PRCP	hsa-miR-339-5p	88.7943	NM_005040
PRCP	hsa-miR-938	88.4576	NM_005040
PRCP	hsa-miR-22-3p	88.3045	NM_001319214
PRCP	hsa-miR-10398-5p	86.53	NM_005040
PRCP	hsa-miR-526b-3p	83.7703	NM_001319214
PRCP	hsa-miR-20a-5p	82.4508	NM_001319214
PRCP	hsa-miR-106b-5p	82.4508	NM_001319214
PRCP	hsa-miR-17-5p	82.4508	NM_001319214
PRCP	hsa-miR-106a-5p	82.4508	NM_001319214
PRCP	hsa-miR-519d-3p	82.4508	NM_001319214
PRCP	hsa-miR-20b-5p	82.4508	NM_001319214
PRCP	hsa-miR-93-5p	82.4508	NM_001319214
PRCP	hsa-miR-4762-5p	82.2995	NM_005040
PRCP	hsa-miR-9983-3p	80.5384	NM_005040
PRCP	hsa-miR-4666a-5p	80.263	NM_005040

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Motifs and transcription factors (TFs) regulating PRCP

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PRCP	metacluster_172.6	CHD2; E2F1 (directAnnotation).
PRCP	metacluster_162.1	ZNF224 (directAnnotation).
PRCP	taipale_cyt_meth__CDX2_NRTCGTAAANNN_eDBD_meth	CDX2 (directAnnotation).
PRCP	taipale_tf_pairs__FLI1_CEBPD_RNCGGANNTTGCGCAAN_CAP	CEBPD; FLI1 (directAnnotation).
PRCP	transfac_pro__M04886	ETS1 (directAnnotation).
PRCP	hocomoco__OTX1_HUMAN.H11MO.0.D	OTX1 (directAnnotation).
PRCP	metacluster_167.5	EHF; ELF5; NFATC3; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPIB; SPIB; SPIB; SPIB; SPIB; SPIB; SPIB; SPIB; SPIB; SPIB; SPIC; SPIC; STAT5A (directAnnotation). ETS1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPIB; SPIC (inferredBy_Orthology).
PRCP	hdpi__TP73	TP73 (directAnnotation).
PRCP	transfac_pro__M04913	ZBTB7A (directAnnotation).

Page: 1

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."