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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PPP6R3

Summary for PPP6R3

Gene information	Gene symbol	PPP6R3
	Ensembl ID	ENSG00000110075
	Entrez ID	55291
	Gene name	protein phosphatase 6 regulatory subunit 3
	Synonyms	C11orf23\|DKFZp781E17107\|DKFZp781E2374\|DKFZp781O2362\|FLJ11058\|FLJ43065\|KIAA1558\|MGC125711\|MGC125712\|PP6R3\|SAP190\|SAPL\|SAPLa\|SAPS3
	Gene type	protein_coding
	UniProtAcc	Q5H9R7

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Dataset with differentially expressed gene: PPP6R3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.256003	1.67e-25

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Expression of PPP6R3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PPP6R3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PPP6R3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PPP6R3	hsa-miR-3646	99.4445	NM_001164160
PPP6R3	hsa-miR-338-5p	98.7081	NM_001164160
PPP6R3	hsa-miR-34b-3p	98.2761	NM_001164160
PPP6R3	hsa-miR-6508-5p	97.3112	NM_001164160
PPP6R3	hsa-miR-624-3p	96.3046	NM_001164160
PPP6R3	hsa-miR-8067	96.1491	NM_001164160
PPP6R3	hsa-miR-3662	96.0818	NM_001164160
PPP6R3	hsa-miR-4666a-3p	95.6647	NM_001164160
PPP6R3	hsa-miR-29b-1-5p	94.7622	NM_001164160
PPP6R3	hsa-let-7c-3p	94.7041	NM_001164160
PPP6R3	hsa-miR-6805-3p	93.1602	NM_001164160
PPP6R3	hsa-miR-5691	93.1602	NM_001164160
PPP6R3	hsa-miR-4474-5p	92.5568	NM_001164164
PPP6R3	hsa-miR-5587-5p	92.3253	NM_001164160
PPP6R3	hsa-miR-135a-5p	91.8703	NM_001164160
PPP6R3	hsa-miR-135b-5p	91.8703	NM_001164160
PPP6R3	hsa-miR-660-5p	91.0331	NM_001164160
PPP6R3	hsa-miR-6748-3p	89.9504	NM_001164160
PPP6R3	hsa-miR-6833-3p	89.5125	NM_001164160
PPP6R3	hsa-miR-194-3p	89.4652	NM_001164164
PPP6R3	hsa-miR-3187-3p	88.9218	NM_001164160
PPP6R3	hsa-miR-4761-5p	88.8371	NM_001164160
PPP6R3	hsa-miR-3171	88.528	NM_001164160
PPP6R3	hsa-miR-6504-3p	88.4401	NM_001164160
PPP6R3	hsa-miR-10399-5p	88.4401	NM_001164160
PPP6R3	hsa-miR-498-5p	88.0647	NM_001164160
PPP6R3	hsa-miR-216b-3p	87.5992	NM_001164160
PPP6R3	hsa-miR-4703-5p	87.196	NM_001164160
PPP6R3	hsa-miR-552-3p	87.1853	NM_001164160
PPP6R3	hsa-miR-126-5p	86.3054	NM_001164160
PPP6R3	hsa-miR-501-5p	85.8544	NM_001164160
PPP6R3	hsa-miR-544b	85.8375	NM_001164160
PPP6R3	hsa-miR-6757-3p	85.5851	NM_001164160
PPP6R3	hsa-miR-6813-3p	85.5813	NM_001164160
PPP6R3	hsa-miR-4733-3p	85.5131	NM_001164160
PPP6R3	hsa-miR-640	85.1869	NM_001164160
PPP6R3	hsa-miR-6852-3p	85.177	NM_001164164
PPP6R3	hsa-miR-6770-5p	85.1498	NM_001164160
PPP6R3	hsa-miR-4684-5p	84.2899	NM_001164160
PPP6R3	hsa-miR-3942-5p	84.1153	NM_001164160
PPP6R3	hsa-miR-16-5p	83.9753	NM_001164160
PPP6R3	hsa-miR-15a-5p	83.9753	NM_001164160
PPP6R3	hsa-miR-195-5p	83.9753	NM_001164160
PPP6R3	hsa-miR-15b-5p	83.9753	NM_001164160
PPP6R3	hsa-miR-4768-5p	83.9739	NM_001164160
PPP6R3	hsa-miR-6809-3p	83.9739	NM_001164160
PPP6R3	hsa-miR-570-3p	83.684	NM_001164160
PPP6R3	hsa-miR-34c-3p	83.2301	NM_001164160
PPP6R3	hsa-miR-4495	82.9019	NM_001164160
PPP6R3	hsa-miR-548ar-3p	82.2372	NM_001164160

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Motifs and transcription factors (TFs) regulating PPP6R3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PPP6R3	metacluster_7.13	ZFX (directAnnotation).
PPP6R3	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
PPP6R3	cisbp__M00968	MTF2 (directAnnotation).
PPP6R3	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
PPP6R3	cisbp__M00341	PAX6 (directAnnotation).
PPP6R3	metacluster_198.3	ZFP64 (directAnnotation).
PPP6R3	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
PPP6R3	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
PPP6R3	cisbp__M00788	ZFY (inferredBy_Orthology).
PPP6R3	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
PPP6R3	metacluster_151.2	ZNF23 (directAnnotation).
PPP6R3	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
PPP6R3	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."