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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PPP6C

Summary for PPP6C

Gene information	Gene symbol	PPP6C
	Ensembl ID	ENSG00000119414
	Entrez ID	5537
	Gene name	protein phosphatase 6 catalytic subunit
	Synonyms	PP6
	Gene type	protein_coding
	UniProtAcc	O00743

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Dataset with differentially expressed gene: PPP6C

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.25292	5.91e-38
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.271394	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.253992	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.40298	3.88e-27
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.257088	0.00e+00

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Expression of PPP6C in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PPP6C

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PPP6C

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PPP6C	hsa-miR-95-5p	99.2628	NM_001123355
PPP6C	hsa-miR-4282	99.2549	NM_001123355
PPP6C	hsa-miR-7158-5p	99.2481	NM_001123355
PPP6C	hsa-miR-6891-5p	97.5703	NM_001123369
PPP6C	hsa-miR-302e	97.5001	NM_001123355
PPP6C	hsa-miR-12118	97.4714	NM_001123369
PPP6C	hsa-miR-3173-3p	97.429	NM_001123369
PPP6C	hsa-miR-12136	97.1555	NM_001123369
PPP6C	hsa-miR-302a-3p	97.0207	NM_001123355
PPP6C	hsa-miR-302d-3p	97.0207	NM_001123355
PPP6C	hsa-miR-520d-3p	97.0207	NM_001123355
PPP6C	hsa-miR-373-3p	97.0207	NM_001123355
PPP6C	hsa-miR-302b-3p	97.0207	NM_001123355
PPP6C	hsa-miR-520e-3p	97.0207	NM_001123355
PPP6C	hsa-miR-302c-3p	97.0207	NM_001123355
PPP6C	hsa-miR-520b-3p	97.0207	NM_001123355
PPP6C	hsa-miR-520a-3p	97.0207	NM_001123355
PPP6C	hsa-miR-372-3p	97.0207	NM_001123355
PPP6C	hsa-miR-520c-3p	97.0207	NM_001123355
PPP6C	hsa-miR-548l	96.941	NM_001123355
PPP6C	hsa-miR-4291	95.5495	NM_001123369
PPP6C	hsa-miR-548x-3p	95.468	NM_001123355
PPP6C	hsa-miR-548aj-3p	95.468	NM_001123355
PPP6C	hsa-miR-526b-3p	95.2848	NM_001123355
PPP6C	hsa-miR-106a-5p	95.2848	NM_001123355
PPP6C	hsa-miR-106b-5p	95.2713	NM_001123355
PPP6C	hsa-miR-20a-5p	95.2713	NM_001123355
PPP6C	hsa-miR-129-2-3p	95.237	NM_001123355
PPP6C	hsa-miR-129-1-3p	95.237	NM_001123355
PPP6C	hsa-miR-32-3p	95.1175	NM_001123355
PPP6C	hsa-miR-548j-3p	94.2305	NM_001123355
PPP6C	hsa-miR-548am-3p	94.2305	NM_001123355
PPP6C	hsa-miR-548aq-3p	94.2305	NM_001123355
PPP6C	hsa-miR-548ah-3p	94.2305	NM_001123355
PPP6C	hsa-miR-548ae-3p	94.2305	NM_001123355
PPP6C	hsa-miR-524-5p	94.1992	NM_001123355
PPP6C	hsa-miR-520d-5p	94.1992	NM_001123355
PPP6C	hsa-miR-17-5p	93.8951	NM_001123355
PPP6C	hsa-miR-93-5p	93.8951	NM_001123355
PPP6C	hsa-miR-20b-5p	93.8951	NM_001123355
PPP6C	hsa-miR-519d-3p	93.8951	NM_001123355
PPP6C	hsa-miR-3119	93.8614	NM_001123369
PPP6C	hsa-miR-300	93.6724	NM_001123355
PPP6C	hsa-miR-381-3p	93.6724	NM_001123355
PPP6C	hsa-miR-496	93.5175	NM_001123369
PPP6C	hsa-miR-3619-5p	92.8443	NM_001123355
PPP6C	hsa-miR-4666a-3p	92.5557	NM_001123355
PPP6C	hsa-miR-107	92.4403	NM_001123355
PPP6C	hsa-miR-103a-3p	92.4403	NM_001123355
PPP6C	hsa-miR-761	91.1566	NM_001123355

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Motifs and transcription factors (TFs) regulating PPP6C

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PPP6C	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
PPP6C	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
PPP6C	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
PPP6C	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
PPP6C	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
PPP6C	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
PPP6C	metacluster_34.4	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
PPP6C	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
PPP6C	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
PPP6C	taipale_tf_pairs__ELK1_TEF_NSCGGAWNTTACGTAAN_CAP	ELK1; TEF (directAnnotation).
PPP6C	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
PPP6C	cisbp__M08198	ELF1 (directAnnotation).
PPP6C	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
PPP6C	taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP	ETV1; HOXB2 (directAnnotation).
PPP6C	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).
PPP6C	taipale_tf_pairs__ETV2_TEF_RSCGGAWNTTRCGYAAN_CAP	ETV2; TEF (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."