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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PPP2R2D

Summary for PPP2R2D

Gene information	Gene symbol	PPP2R2D
	Ensembl ID	ENSG00000175470
	Entrez ID	55844
	Gene name	protein phosphatase 2 regulatory subunit Bdelta
	Synonyms	B55D\|B55delta\|MDS026
	Gene type	protein_coding
	UniProtAcc	Q66LE6

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Dataset with differentially expressed gene: PPP2R2D

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.343213	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.250164	1.49e-34

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Expression of PPP2R2D in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PPP2R2D

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PPP2R2D

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PPP2R2D	hsa-miR-6798-5p	99.9999	NM_001291310
PPP2R2D	hsa-miR-3617-3p	99.9821	NM_001291310
PPP2R2D	hsa-miR-4525	99.9365	NM_001291310
PPP2R2D	hsa-miR-5010-5p	99.9365	NM_001291310
PPP2R2D	hsa-miR-329-3p	99.9105	NM_001291310
PPP2R2D	hsa-miR-362-3p	99.9105	NM_001291310
PPP2R2D	hsa-miR-3065-3p	99.8677	NM_001291310
PPP2R2D	hsa-miR-383-3p	99.8468	NM_001291310
PPP2R2D	hsa-miR-6794-5p	99.7617	NM_001291310
PPP2R2D	hsa-miR-4716-3p	99.689	NM_001291310
PPP2R2D	hsa-miR-452-3p	99.0148	NM_001291310
PPP2R2D	hsa-miR-1228-3p	99.0009	NM_001291310
PPP2R2D	hsa-miR-1275	98.6273	NM_001291310
PPP2R2D	hsa-miR-205-5p	98.5718	NM_001291310
PPP2R2D	hsa-miR-133b	97.6562	NM_001291310
PPP2R2D	hsa-miR-133a-3p	97.6562	NM_001291310
PPP2R2D	hsa-miR-7111-5p	94.4502	NM_001291310
PPP2R2D	hsa-miR-6870-5p	94.4502	NM_001291310
PPP2R2D	hsa-miR-4723-5p	94.4502	NM_001291310
PPP2R2D	hsa-miR-5698	94.4502	NM_001291310
PPP2R2D	hsa-miR-144-3p	93.9841	NM_001291310
PPP2R2D	hsa-miR-4282	92.347	NM_001291310
PPP2R2D	hsa-miR-4665-5p	91.9031	NM_001291310
PPP2R2D	hsa-miR-625-5p	91.0084	NM_001291310
PPP2R2D	hsa-miR-1306-5p	89.7204	NM_001291310
PPP2R2D	hsa-miR-4696	88.6576	NM_001291310
PPP2R2D	hsa-miR-4526	87.9247	NM_001291310
PPP2R2D	hsa-miR-3660	87.9247	NM_001291310
PPP2R2D	hsa-miR-4441	87.3522	NM_001291310
PPP2R2D	hsa-miR-4270	87.3522	NM_001291310
PPP2R2D	hsa-miR-92b-5p	87.185	NM_001291310
PPP2R2D	hsa-miR-6880-3p	85.9479	NM_001291310
PPP2R2D	hsa-miR-601	85.3415	NM_001291310
PPP2R2D	hsa-miR-6843-3p	85.009	NM_001291310
PPP2R2D	hsa-miR-6848-3p	85.009	NM_001291310
PPP2R2D	hsa-miR-597-5p	83.562	NM_001291310
PPP2R2D	hsa-miR-4775	81.3692	NM_001291310
PPP2R2D	hsa-miR-194-3p	80.1839	NM_001291310

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Motifs and transcription factors (TFs) regulating PPP2R2D

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PPP2R2D	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
PPP2R2D	metacluster_191.5	SPDEF (inferredBy_Orthology).
PPP2R2D	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
PPP2R2D	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
PPP2R2D	metacluster_111.3	ATF1; ATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREM; CREM; CREM; CREM; E4F1; E4F1 (directAnnotation). CREB1; CREB1; CREM; JDP2 (inferredBy_Orthology).
PPP2R2D	tfdimers__MD00038	TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."