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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: PPP2R2A

Summary for PPP2R2A

Gene information	Gene symbol	PPP2R2A
	Ensembl ID	ENSG00000221914
	Entrez ID	5520
	Gene name	protein phosphatase 2 regulatory subunit Balpha
	Synonyms	B55A\|B55alpha\|PR52A\|PR55A\|PR55alpha
	Gene type	protein_coding
	UniProtAcc	P63151

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Dataset with differentially expressed gene: PPP2R2A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.26579	6.70e-05
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.293883	4.37e-10
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.292591	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.624197	0.00e+00

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Expression of PPP2R2A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PPP2R2A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PPP2R2A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PPP2R2A	hsa-miR-12136	99.9234	NM_001177591
PPP2R2A	hsa-miR-136-5p	99.498	NM_001177591
PPP2R2A	hsa-miR-187-5p	97.23	NM_001177591
PPP2R2A	hsa-miR-4775	97.0795	NM_001177591
PPP2R2A	hsa-miR-605-5p	96.5736	NM_001177591
PPP2R2A	hsa-miR-3910	95.5109	NM_001177591
PPP2R2A	hsa-miR-554	94.0974	NM_001177591
PPP2R2A	hsa-miR-10522-5p	93.9178	NM_001177591
PPP2R2A	hsa-miR-1179	92.5945	NM_001177591
PPP2R2A	hsa-miR-144-3p	92.1364	NM_001177591
PPP2R2A	hsa-miR-101-3p	92.1364	NM_001177591
PPP2R2A	hsa-miR-548t-5p	92.0198	NM_001177591
PPP2R2A	hsa-miR-548az-5p	92.0198	NM_001177591
PPP2R2A	hsa-miR-130a-5p	90.9628	NM_001177591
PPP2R2A	hsa-miR-6757-3p	90.5845	NM_001177591
PPP2R2A	hsa-miR-4719	90.4149	NM_001177591
PPP2R2A	hsa-miR-519e-5p	89.9695	NM_001177591
PPP2R2A	hsa-miR-515-5p	89.9695	NM_001177591
PPP2R2A	hsa-miR-222-3p	89.441	NM_001177591
PPP2R2A	hsa-miR-548v	89.441	NM_001177591
PPP2R2A	hsa-miR-221-3p	89.441	NM_001177591
PPP2R2A	hsa-miR-6507-5p	88.4402	NM_001177591
PPP2R2A	hsa-miR-222-5p	87.967	NM_001177591
PPP2R2A	hsa-miR-3202	87.8877	NM_001177591
PPP2R2A	hsa-miR-183-5p	87.5923	NM_001177591
PPP2R2A	hsa-miR-32-3p	87.3504	NM_001177591
PPP2R2A	hsa-miR-607	87.2508	NM_001177591
PPP2R2A	hsa-miR-425-5p	87.0278	NM_001177591
PPP2R2A	hsa-miR-12115	86.9071	NM_001177591
PPP2R2A	hsa-miR-6844	86.1523	NM_001177591
PPP2R2A	hsa-miR-150-5p	85.4736	NM_001177591
PPP2R2A	hsa-miR-590-3p	84.7294	NM_001177591
PPP2R2A	hsa-miR-6809-3p	84.5409	NM_001177591
PPP2R2A	hsa-miR-4533	84.435	NM_001177591
PPP2R2A	hsa-miR-605-3p	84.1043	NM_001177591
PPP2R2A	hsa-miR-1208	83.4993	NM_001177591
PPP2R2A	hsa-miR-3671	83.1057	NM_001177591
PPP2R2A	hsa-miR-3679-5p	81.4515	NM_001177591
PPP2R2A	hsa-miR-148a-5p	81.1067	NM_001177591
PPP2R2A	hsa-miR-4477a	81.0994	NM_001177591
PPP2R2A	hsa-miR-6507-3p	80.8623	NM_001177591
PPP2R2A	hsa-miR-218-5p	80.5552	NM_001177591
PPP2R2A	hsa-miR-6760-3p	80.4949	NM_001177591
PPP2R2A	hsa-miR-642b-3p	80.0471	NM_001177591
PPP2R2A	hsa-miR-642a-3p	80.0471	NM_001177591

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Motifs and transcription factors (TFs) regulating PPP2R2A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PPP2R2A	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
PPP2R2A	metacluster_7.13	ZFX (directAnnotation).
PPP2R2A	cisbp__M00968	MTF2 (directAnnotation).
PPP2R2A	metacluster_160.20	JUND; PRDM15 (directAnnotation).
PPP2R2A	cisbp__M00341	PAX6 (directAnnotation).
PPP2R2A	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
PPP2R2A	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
PPP2R2A	metacluster_175.1	ZNF283 (directAnnotation).
PPP2R2A	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
PPP2R2A	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
PPP2R2A	cisbp__M02645	ETS1 (directAnnotation).
PPP2R2A	metacluster_141.2	E2F2; E2F3 (directAnnotation).
PPP2R2A	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
PPP2R2A	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
PPP2R2A	taipale_tf_pairs__FOXO1_ETV1_RCCGGAWGTKKN_CAP	ETV1; FOXO1 (directAnnotation).
PPP2R2A	jaspar__MA0748.2	YY2 (directAnnotation).
PPP2R2A	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
PPP2R2A	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
PPP2R2A	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
PPP2R2A	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
PPP2R2A	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
PPP2R2A	swissregulon__hs__CHD1	CHD1 (directAnnotation).
PPP2R2A	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
PPP2R2A	transfac_pro__M07310	SP5 (directAnnotation).
PPP2R2A	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
PPP2R2A	transfac_pro__M00938	E2F1 (directAnnotation).
PPP2R2A	transfac_pro__M04817	ZBTB33 (directAnnotation).
PPP2R2A	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
PPP2R2A	transfac_pro__M01973	PLAG1 (directAnnotation).
PPP2R2A	transfac_pro__M01303	SP1 (directAnnotation).
PPP2R2A	metacluster_143.13	ZBTB7A (directAnnotation).
PPP2R2A	taipale_tf_pairs__ETV5_EOMES_RNGTGNNNNNNNNNNNNNRCRCCGGAWSN_CAP	EOMES; ETV5 (directAnnotation).
PPP2R2A	hocomoco__XBP1_HUMAN.H11MO.0.D	XBP1 (directAnnotation).
PPP2R2A	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
PPP2R2A	transfac_pro__M02898	SMAD3 (directAnnotation).
PPP2R2A	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
PPP2R2A	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
PPP2R2A	taipale_tf_pairs__GCM2_ELK1_NNRNGGGCGGAARTN_CAP	ELK1; GCM2 (directAnnotation).
PPP2R2A	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
PPP2R2A	hdpi__MYEF2	MYEF2 (directAnnotation).
PPP2R2A	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
PPP2R2A	metacluster_141.4	GLIS2 (directAnnotation).
PPP2R2A	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
PPP2R2A	"2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid"	DB02506	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."