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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: PPP2CB

Summary for PPP2CB

Gene information	Gene symbol	PPP2CB
	Ensembl ID	ENSG00000104695
	Entrez ID	5516
	Gene name	protein phosphatase 2 catalytic subunit beta
	Synonyms	PP2Abeta
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: PPP2CB

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.275239	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.902447	0.00e+00

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Expression of PPP2CB in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PPP2CB

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PPP2CB

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PPP2CB	hsa-miR-6872-3p	97.0849	NM_001009552
PPP2CB	hsa-miR-1185-1-3p	96.8647	NM_001009552
PPP2CB	hsa-miR-1185-2-3p	96.8647	NM_001009552
PPP2CB	hsa-let-7f-2-3p	96.8647	NM_001009552
PPP2CB	hsa-miR-133b	95.347	NM_001009552
PPP2CB	hsa-miR-133a-3p	95.347	NM_001009552
PPP2CB	hsa-miR-95-5p	94.8883	NM_001009552
PPP2CB	hsa-miR-455-3p	93.931	NM_001009552
PPP2CB	hsa-miR-549a-5p	93.6056	NM_001009552
PPP2CB	hsa-miR-183-5p	92.6112	NM_001009552
PPP2CB	hsa-miR-3163	90.697	NM_001009552
PPP2CB	hsa-miR-513a-3p	89.9083	NM_001009552
PPP2CB	hsa-miR-513c-3p	89.9083	NM_001009552
PPP2CB	hsa-miR-3662	89.7483	NM_001009552
PPP2CB	hsa-miR-4690-5p	89.1505	NM_001009552
PPP2CB	hsa-miR-367-5p	88.8227	NM_001009552
PPP2CB	hsa-miR-3129-3p	88.2582	NM_001009552
PPP2CB	hsa-miR-5583-5p	88.2582	NM_001009552
PPP2CB	hsa-miR-3606-3p	88.1584	NM_001009552
PPP2CB	hsa-miR-3646	87.8588	NM_001009552
PPP2CB	hsa-miR-10524-5p	87.4842	NM_001009552
PPP2CB	hsa-miR-5581-3p	87.086	NM_001009552
PPP2CB	hsa-miR-218-5p	86.2413	NM_001009552
PPP2CB	hsa-miR-32-3p	85.6189	NM_001009552
PPP2CB	hsa-miR-761	85.0765	NM_001009552
PPP2CB	hsa-miR-7515	82.5928	NM_001009552
PPP2CB	hsa-miR-4753-3p	81.9388	NM_001009552
PPP2CB	hsa-miR-3619-5p	81.7725	NM_001009552
PPP2CB	hsa-miR-214-3p	81.7725	NM_001009552
PPP2CB	hsa-miR-561-3p	80.8497	NM_001009552

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Motifs and transcription factors (TFs) regulating PPP2CB

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PPP2CB	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
PPP2CB	transfac_pro__M01714	KLF15 (directAnnotation).
PPP2CB	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
PPP2CB	metacluster_135.11	NR2C2 (directAnnotation).
PPP2CB	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
PPP2CB	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
PPP2CB	metacluster_160.20	JUND; PRDM15 (directAnnotation).
PPP2CB	metacluster_198.3	ZFP64 (directAnnotation).
PPP2CB	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
PPP2CB	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
PPP2CB	metacluster_175.1	ZNF283 (directAnnotation).
PPP2CB	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
PPP2CB	transfac_pro__M01199	TRIM28 (directAnnotation).
PPP2CB	metacluster_151.2	ZNF23 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
PPP2CB	"Vitamin E"	DB00163	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."