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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PPP1R3B

Summary for PPP1R3B

Gene information	Gene symbol	PPP1R3B
	Ensembl ID	ENSG00000173281
	Entrez ID	79660
	Gene name	protein phosphatase 1 regulatory subunit 3B
	Synonyms	FLJ14005\|GL\|PPP1R4
	Gene type	protein_coding
	UniProtAcc	Q86XI6

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Dataset with differentially expressed gene: PPP1R3B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.79201	0.00e+00

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Expression of PPP1R3B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PPP1R3B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PPP1R3B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PPP1R3B	hsa-miR-6885-3p	96.7063	NM_001201329
PPP1R3B	hsa-miR-590-5p	95.1412	NM_001201329
PPP1R3B	hsa-miR-21-5p	95.1412	NM_001201329
PPP1R3B	hsa-miR-506-3p	94.7343	NM_001201329
PPP1R3B	hsa-miR-124-3p	94.7343	NM_001201329
PPP1R3B	hsa-miR-20a-5p	94.1141	NM_001201329
PPP1R3B	hsa-miR-106b-5p	93.3791	NM_001201329
PPP1R3B	hsa-miR-519d-3p	92.8171	NM_001201329
PPP1R3B	hsa-miR-3177-5p	92.0637	NM_001201329
PPP1R3B	hsa-miR-20b-5p	91.8811	NM_001201329
PPP1R3B	hsa-miR-4306	91.7779	NM_001201329
PPP1R3B	hsa-miR-331-5p	91.6529	NM_001201329
PPP1R3B	hsa-miR-526b-3p	91.0875	NM_001201329
PPP1R3B	hsa-miR-106a-5p	91.0875	NM_001201329
PPP1R3B	hsa-miR-17-5p	91.0007	NM_001201329
PPP1R3B	hsa-miR-93-5p	91.0007	NM_001201329
PPP1R3B	hsa-miR-3662	90.6308	NM_001201329
PPP1R3B	hsa-miR-4261	90.5307	NM_001201329
PPP1R3B	hsa-miR-10394-5p	89.2501	NM_001201329
PPP1R3B	hsa-miR-1205	89.2501	NM_001201329
PPP1R3B	hsa-miR-362-3p	88.9012	NM_001201329
PPP1R3B	hsa-miR-329-3p	88.9012	NM_001201329
PPP1R3B	hsa-miR-5787	88.8891	NM_001201329
PPP1R3B	hsa-miR-4505	88.8891	NM_001201329
PPP1R3B	hsa-miR-7151-3p	88.7172	NM_001201329
PPP1R3B	hsa-miR-6747-3p	88.6969	NM_001201329
PPP1R3B	hsa-miR-147b-5p	88.3193	NM_001201329
PPP1R3B	hsa-miR-4644	88.0853	NM_001201329
PPP1R3B	hsa-miR-1288-5p	87.4506	NM_001201329
PPP1R3B	hsa-miR-4661-3p	86.4588	NM_001201329
PPP1R3B	hsa-miR-4262	86.3673	NM_001201329
PPP1R3B	hsa-miR-3163	86.194	NM_001201329
PPP1R3B	hsa-miR-3190-3p	86.1318	NM_001201329
PPP1R3B	hsa-miR-3658	86.0643	NM_001201329
PPP1R3B	hsa-miR-4522	85.6821	NM_001201329
PPP1R3B	hsa-miR-185-5p	85.5538	NM_001201329
PPP1R3B	hsa-miR-4276	85.0842	NM_001201329
PPP1R3B	hsa-miR-3140-3p	84.3244	NM_001201329
PPP1R3B	hsa-miR-4715-3p	84.1959	NM_001201329
PPP1R3B	hsa-miR-577	83.9753	NM_001201329
PPP1R3B	hsa-miR-7973	83.1294	NM_001201329
PPP1R3B	hsa-miR-607	83.0142	NM_001201329
PPP1R3B	hsa-miR-519a-3p	82.8052	NM_001201329
PPP1R3B	hsa-miR-519c-3p	82.8052	NM_001201329
PPP1R3B	hsa-miR-519b-3p	82.8052	NM_001201329
PPP1R3B	hsa-miR-205-3p	82.7989	NM_001201329
PPP1R3B	hsa-miR-5197-3p	82.5133	NM_001201329
PPP1R3B	hsa-miR-146a-3p	82.4492	NM_001201329
PPP1R3B	hsa-miR-6871-3p	82.401	NM_001201329
PPP1R3B	hsa-miR-548ba	82.3621	NM_001201329

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Motifs and transcription factors (TFs) regulating PPP1R3B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PPP1R3B	metacluster_135.11	NR2C2 (directAnnotation).
PPP1R3B	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
PPP1R3B	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
PPP1R3B	metacluster_7.13	ZFX (directAnnotation).
PPP1R3B	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
PPP1R3B	cisbp__M00968	MTF2 (directAnnotation).
PPP1R3B	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
PPP1R3B	metacluster_160.20	JUND; PRDM15 (directAnnotation).
PPP1R3B	cisbp__M00341	PAX6 (directAnnotation).
PPP1R3B	metacluster_198.3	ZFP64 (directAnnotation).
PPP1R3B	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
PPP1R3B	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
PPP1R3B	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
PPP1R3B	cisbp__M00788	ZFY (inferredBy_Orthology).
PPP1R3B	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
PPP1R3B	metacluster_175.1	ZNF283 (directAnnotation).
PPP1R3B	hdpi__ZNF304	ZNF304 (directAnnotation).
PPP1R3B	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
PPP1R3B	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
PPP1R3B	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
PPP1R3B	transfac_pro__M01199	TRIM28 (directAnnotation).
PPP1R3B	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
PPP1R3B	metacluster_151.2	ZNF23 (directAnnotation).
PPP1R3B	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
PPP1R3B	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
PPP1R3B	transfac_pro__M03806	ZBTB7C (directAnnotation).
PPP1R3B	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."