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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PPP1R1A

Summary for PPP1R1A

Gene information	Gene symbol	PPP1R1A
	Ensembl ID	ENSG00000135447
	Entrez ID	5502
	Gene name	protein phosphatase 1 regulatory inhibitor subunit 1A
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: PPP1R1A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.516078	0.00e+00

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Expression of PPP1R1A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PPP1R1A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PPP1R1A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PPP1R1A	hsa-miR-5011-5p	99.9963	NM_006741
PPP1R1A	hsa-miR-190a-3p	99.9587	NM_006741
PPP1R1A	hsa-miR-1252-5p	93.8155	NM_006741
PPP1R1A	hsa-miR-4530	93.3619	NM_006741
PPP1R1A	hsa-miR-6124	91.2518	NM_006741
PPP1R1A	hsa-miR-4469	90.8809	NM_006741
PPP1R1A	hsa-miR-7851-3p	85.6876	NM_006741
PPP1R1A	hsa-miR-1207-5p	83.5667	NM_006741
PPP1R1A	hsa-miR-6867-5p	82.9323	NM_006741
PPP1R1A	hsa-miR-6867-3p	82.7539	NM_006741
PPP1R1A	hsa-miR-4763-3p	82.6319	NM_006741
PPP1R1A	hsa-miR-548ah-5p	82.5042	NM_006741
PPP1R1A	hsa-miR-3609	82.5042	NM_006741
PPP1R1A	hsa-miR-4713-5p	81.4608	NM_006741
PPP1R1A	hsa-miR-21-3p	80.2871	NM_006741
PPP1R1A	hsa-miR-122b-3p	80.2871	NM_006741

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Motifs and transcription factors (TFs) regulating PPP1R1A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."