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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PPP1R16B

Summary for PPP1R16B

Gene information	Gene symbol	PPP1R16B
	Ensembl ID	ENSG00000101445
	Entrez ID	26051
	Gene name	protein phosphatase 1 regulatory subunit 16B
	Synonyms	ANKRD4\|KIAA0823\|TIMAP
	Gene type	protein_coding
	UniProtAcc	Q96T49

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Dataset with differentially expressed gene: PPP1R16B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.324549	6.95e-41

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Expression of PPP1R16B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PPP1R16B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PPP1R16B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PPP1R16B	hsa-miR-6867-5p	100	NM_001172735
PPP1R16B	hsa-miR-6891-5p	95.4712	NM_001172735
PPP1R16B	hsa-miR-3173-3p	94.5693	NM_001172735
PPP1R16B	hsa-miR-12118	94.5693	NM_001172735
PPP1R16B	hsa-miR-4469	92.0108	NM_001172735
PPP1R16B	hsa-miR-4299	91.5597	NM_001172735
PPP1R16B	hsa-miR-4492	91.1204	NM_001172735
PPP1R16B	hsa-miR-4500	90.8131	NM_001172735
PPP1R16B	hsa-miR-590-3p	89.6625	NM_001172735
PPP1R16B	hsa-miR-144-3p	89.1014	NM_001172735
PPP1R16B	hsa-miR-6793-3p	88.988	NM_001172735
PPP1R16B	hsa-miR-4505	88.9118	NM_001172735
PPP1R16B	hsa-let-7d-5p	88.6423	NM_001172735
PPP1R16B	hsa-miR-4458	88.6423	NM_001172735
PPP1R16B	hsa-let-7g-5p	88.6423	NM_001172735
PPP1R16B	hsa-let-7f-5p	88.6423	NM_001172735
PPP1R16B	hsa-let-7i-5p	88.6423	NM_001172735
PPP1R16B	hsa-miR-98-5p	88.6423	NM_001172735
PPP1R16B	hsa-let-7e-5p	88.6423	NM_001172735
PPP1R16B	hsa-let-7a-5p	88.6423	NM_001172735
PPP1R16B	hsa-let-7b-5p	88.6423	NM_001172735
PPP1R16B	hsa-let-7c-5p	88.6423	NM_001172735
PPP1R16B	hsa-miR-4641	88.5582	NM_001172735
PPP1R16B	hsa-miR-449a	88.4402	NM_001172735
PPP1R16B	hsa-miR-34a-5p	88.4402	NM_001172735
PPP1R16B	hsa-miR-4999-5p	88.3198	NM_001172735
PPP1R16B	hsa-miR-5787	88.0079	NM_001172735
PPP1R16B	hsa-miR-6828-5p	87.1514	NM_001172735
PPP1R16B	hsa-miR-4521	86.4816	NM_001172735
PPP1R16B	hsa-miR-449b-5p	86.3188	NM_001172735
PPP1R16B	hsa-miR-34c-5p	86.3188	NM_001172735
PPP1R16B	hsa-miR-4260	84.9046	NM_001172735
PPP1R16B	hsa-miR-4797-5p	84.8943	NM_001172735
PPP1R16B	hsa-miR-6780a-3p	84.6754	NM_001172735
PPP1R16B	hsa-miR-1301-3p	83.7997	NM_001172735
PPP1R16B	hsa-miR-5047	83.7997	NM_001172735
PPP1R16B	hsa-miR-24-3p	83.7196	NM_001172735
PPP1R16B	hsa-miR-6721-5p	83.2914	NM_001172735
PPP1R16B	hsa-miR-10398-5p	83.1817	NM_001172735
PPP1R16B	hsa-miR-4775	82.541	NM_001172735
PPP1R16B	hsa-miR-4498	82.5089	NM_001172735
PPP1R16B	hsa-miR-7113-5p	82.2523	NM_001172735
PPP1R16B	hsa-miR-3934-5p	82.103	NM_001172735
PPP1R16B	hsa-miR-7977	82.0746	NM_001172735
PPP1R16B	hsa-miR-1185-1-3p	81.9698	NM_001172735
PPP1R16B	hsa-let-7f-2-3p	81.9698	NM_001172735
PPP1R16B	hsa-miR-1185-2-3p	81.9698	NM_001172735
PPP1R16B	hsa-miR-4313	81.7356	NM_001172735
PPP1R16B	hsa-miR-6805-5p	81.364	NM_001172735
PPP1R16B	hsa-miR-5088-3p	81.2766	NM_001172735

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Motifs and transcription factors (TFs) regulating PPP1R16B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PPP1R16B	transfac_pro__M00801	ATF1; ATF2; ATF3; ATF4; ATF7; CREB1; CREM (directAnnotation). ATF7-NPFF (inferredBy_Orthology).
PPP1R16B	transfac_pro__M02089	E2F3 (directAnnotation).
PPP1R16B	transfac_pro__M07436	WT1 (directAnnotation).
PPP1R16B	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
PPP1R16B	transfac_pro__M04817	ZBTB33 (directAnnotation).
PPP1R16B	transfac_pro__M04746	E2F1 (directAnnotation).
PPP1R16B	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
PPP1R16B	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
PPP1R16B	transfac_pro__M07329	SP7 (directAnnotation).
PPP1R16B	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
PPP1R16B	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
PPP1R16B	cisbp__M07938	E2F1 (directAnnotation).
PPP1R16B	transfac_pro__M07310	SP5 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."