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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PPP1R11

Summary for PPP1R11

Gene information	Gene symbol	PPP1R11
	Ensembl ID	ENSG00000236560
	Entrez ID	6992
	Gene name	protein phosphatase 1 regulatory inhibitor subunit 11
	Synonyms	CFAP255\|HCG-V\|HCGV\|TCTE5\|Tctex5
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: PPP1R11

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.576207	2.97e-03
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.558541	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.370674	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.265038	4.20e-45
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.277461	4.32e-13
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.348079	1.47e-13
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.461557	1.95e-31
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.263288	2.84e-06
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.406409	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.628831	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.250177	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.278216	0.00e+00

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Expression of PPP1R11 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PPP1R11

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PPP1R11

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PPP1R11	hsa-miR-34a-5p	99.3582	NM_021959
PPP1R11	hsa-miR-34c-5p	99.1682	NM_021959
PPP1R11	hsa-miR-449a	99.1353	NM_021959
PPP1R11	hsa-miR-449b-5p	98.8773	NM_021959
PPP1R11	hsa-miR-7153-5p	96.7355	NM_021959
PPP1R11	hsa-miR-146b-5p	96.7355	NM_021959
PPP1R11	hsa-miR-146a-5p	96.7355	NM_021959
PPP1R11	hsa-miR-4692	96.6715	NM_021959
PPP1R11	hsa-miR-548au-3p	96.0826	NM_021959
PPP1R11	hsa-miR-4514	95.6581	NM_021959
PPP1R11	hsa-miR-589-5p	93.982	NM_021959
PPP1R11	hsa-miR-15a-5p	93.8575	NM_021959
PPP1R11	hsa-miR-15b-5p	93.8575	NM_021959
PPP1R11	hsa-miR-16-5p	93.8575	NM_021959
PPP1R11	hsa-miR-195-5p	93.8575	NM_021959
PPP1R11	hsa-miR-3154	93.7105	NM_021959
PPP1R11	hsa-miR-3688-5p	92.4315	NM_021959
PPP1R11	hsa-miR-6780a-5p	92.2079	NM_021959
PPP1R11	hsa-miR-3159	91.7941	NM_021959
PPP1R11	hsa-miR-6838-5p	91.3372	NM_021959
PPP1R11	hsa-miR-497-5p	91.3372	NM_021959
PPP1R11	hsa-miR-424-5p	91.3372	NM_021959
PPP1R11	hsa-miR-8070	91.0129	NM_021959
PPP1R11	hsa-miR-877-3p	90.7921	NM_021959
PPP1R11	hsa-miR-3689b-3p	89.9602	NM_021959
PPP1R11	hsa-miR-30b-3p	89.9602	NM_021959
PPP1R11	hsa-miR-3689a-3p	89.9602	NM_021959
PPP1R11	hsa-miR-1273h-5p	89.9602	NM_021959
PPP1R11	hsa-miR-6779-5p	89.9602	NM_021959
PPP1R11	hsa-miR-3689c	89.9602	NM_021959
PPP1R11	hsa-miR-6804-5p	89.6188	NM_021959
PPP1R11	hsa-miR-2113	89.1898	NM_021959
PPP1R11	hsa-miR-6840-3p	89.0556	NM_021959
PPP1R11	hsa-miR-1296-5p	88.7622	NM_021959
PPP1R11	hsa-miR-1252-3p	88.374	NM_021959
PPP1R11	hsa-miR-4524b-5p	87.6806	NM_021959
PPP1R11	hsa-miR-4524a-5p	87.6806	NM_021959
PPP1R11	hsa-miR-587	87.411	NM_021959
PPP1R11	hsa-miR-182-5p	86.7914	NM_021959
PPP1R11	hsa-miR-4492	86.2545	NM_021959
PPP1R11	hsa-miR-6756-5p	85.5319	NM_021959
PPP1R11	hsa-miR-7106-5p	84.6803	NM_021959
PPP1R11	hsa-miR-3936	84.272	NM_021959
PPP1R11	hsa-miR-96-5p	82.6341	NM_021959
PPP1R11	hsa-miR-6770-5p	82.5795	NM_021959
PPP1R11	hsa-miR-6766-5p	81.3578	NM_021959
PPP1R11	hsa-miR-4498	80.9998	NM_021959
PPP1R11	hsa-miR-6881-3p	80.7087	NM_021959
PPP1R11	hsa-miR-5001-5p	80.1636	NM_021959

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Motifs and transcription factors (TFs) regulating PPP1R11

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PPP1R11	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
PPP1R11	jaspar__MA1483.2	ELF2 (directAnnotation).
PPP1R11	hdpi__ETV4	ETV4 (directAnnotation).
PPP1R11	jaspar__MA1933.1	SREBF2 (directAnnotation).
PPP1R11	transfac_pro__M04826	EP300 (directAnnotation).
PPP1R11	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
PPP1R11	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
PPP1R11	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
PPP1R11	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
PPP1R11	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
PPP1R11	cisbp__M08198	ELF1 (directAnnotation).
PPP1R11	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
PPP1R11	transfac_pro__M00652	NRF1 (directAnnotation).
PPP1R11	transfac_pro__M04866	HDAC2 (directAnnotation).
PPP1R11	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
PPP1R11	swissregulon__hs__ELF2	ELF2 (directAnnotation).
PPP1R11	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
PPP1R11	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
PPP1R11	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
PPP1R11	hdpi__FLI1	FLI1 (directAnnotation).
PPP1R11	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
PPP1R11	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
PPP1R11	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
PPP1R11	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
PPP1R11	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
PPP1R11	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
PPP1R11	cisbp__M02645	ETS1 (directAnnotation).
PPP1R11	jaspar__MA1708.1	ETV7 (directAnnotation).
PPP1R11	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
PPP1R11	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
PPP1R11	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
PPP1R11	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
PPP1R11	taipale_tf_pairs__ELK1_HOXA3_RSCGGTAATKR_CAP_repr	ELK1; HOXA3 (directAnnotation).
PPP1R11	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
PPP1R11	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
PPP1R11	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
PPP1R11	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
PPP1R11	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
PPP1R11	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).
PPP1R11	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
PPP1R11	taipale_tf_pairs__ELK1_TEF_NSCGGAWNTTACGTAAN_CAP	ELK1; TEF (directAnnotation).
PPP1R11	metacluster_160.20	JUND; PRDM15 (directAnnotation).
PPP1R11	transfac_pro__M04794	TAF1 (directAnnotation).
PPP1R11	taipale_tf_pairs__FOXO1_ETV1_RCCGGAWGTKKN_CAP	ETV1; FOXO1 (directAnnotation).
PPP1R11	transfac_pro__M00492	STAT1 (directAnnotation).
PPP1R11	hdpi__TP73	TP73 (directAnnotation).
PPP1R11	hdpi__ELF2	ELF2 (directAnnotation).
PPP1R11	swissregulon__hs__ELK1	ELK1 (directAnnotation).
PPP1R11	metacluster_183.4	ETS1 (inferredBy_Orthology).
PPP1R11	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."